Neural Cell News

Neural Cell News is an online resource covering the latest research in neuroscience, neural stem cells, and neurological conditions.

An Antisense Oligonucleotide-Loaded Blood–Brain Barrier Penetrable Nanoparticle Mediating Recruitment of Endogenous Neural Stem Cells for the Treatment of Parkinson’s Disease

[ACS Nano] ZAAM, an antisense oligonucleotide-loaded, aptamer Apt 19S-conjugated, neural stem cell membrane-coated nanoparticle, was developed for the targeted treatment of Parkinson's disease.

PGC-1α Degradation Suppresses Mitochondrial Biogenesis to Confer Radiation Resistance in Glioma

[CANCER RESEARCH] Investigators reported that mitochondrial metabolic pathways were suppressed in radioresistant gliomas through integrated analyses of transcriptomic data from glioma specimens and cell lines.

Telomerase Inhibition Is an Effective Therapeutic Strategy in TERT Promoter Mutant-Glioblastoma Models with Low Tumor Volume

[Neuro-Oncology] Researchers used CRISPR interference to knock down TERT expression in TERT promoter-mutant glioblastoma cell lines and patient-derived models. They then measured viability using serial proliferation assays.

Schwann Cell-Derived Exosomes Containing MFG-E8 Modify Macrophage/Microglial Polarization for Attenuating Inflammation via the SOCS3/STAT3 Pathway after Spinal Cord Injury

[Cell Death & Disease] Investigators studied the effect of Schwann cell-derived exosomes on regulating the inflammation related to macrophage polarization during the recovery of spinal cord injury.

Neuronal and Astrocytic CB1R Signaling Differentially Modulates Goal-Directed Behavior and Working Memory by Distinct Temporal Mechanisms

[Neuropsychopharmacology] The authors demonstrated that light stimulation of opto-cannabinoid receptor 1 (CB1R) triggered canonical CB1R signaling by inhibiting cAMP, but not cGMP or IP1, signaling and activating the MAPK pathway in vitro or in vivo.

Cortical-Blood Vessel Assembloids Exhibit Alzheimer’s Disease Phenotypes by Activating Glia after SARS-CoV-2 Infection

[Cell Death Discovery] Scientists revealed that exogenous irisin conferred neuroprotection relieving apoptosis and oxidative stress, restraining mitochondrial fragmentation, and promoting mitochondrial respiration and biogenesis in Parkinson's diease models, and irisin exerted the aforementioned effects by activating Akt signaling pathway and ERK1/2 signaling pathway.

Irisin Exhibits Neuroprotection by Preventing Mitochondrial Damage in Parkinson’s Disease

[NPJ Parkinson's Disease] The authors study the functional and transcriptomic impacts of such media on human microglia (hMGL). They provide a better understanding of hMGL in culture, with observations that diverge from those previously made in rodent microglia.

Metabolic Rewiring in MYC-Driven Medulloblastoma by Bet-Bromodomain Inhibition

[Scientific Reports] Researchers explored the metabolic features characterizing MYC-driven medulloblastoma and examined how these were altered by BET-bromodomain inhibition.

Protein Interaction Studies in Human Induced Neurons Indicate Convergent Biology Underlying Autism Spectrum Disorders

[Cell Genomics] Scientists built a protein-protein interaction network for 13 Autism spectrum disorder-associated genes in human excitatory neurons derived from induced pluripotent stem cells.

Marketing Authorization Application for Lecanemab as Treatment for Early Alzheimer’s Disease Accepted by European Medicines Agency

[Biogen, Inc.] Eisai Co., Ltd. and Biogen Inc. announced that the European Medicines Agency had accepted a marketing authorization application for lecanemab, an investigational anti-amyloid beta protofibril antibody, for the treatment of early Alzheimer’s disease with confirmed amyloid pathology, for review following a standard timeline.

Psychological and Biological Mechanisms Linking Trauma with Cardiovascular Disease Risk

[Translational Psychiatry] Investigators summarize the evidence for key psychological and biological mechanisms linking experiences of trauma with cardiovascular disease risk. Additionally, they describe various methodologies for measuring these mechanisms in an effort to inform future research related to potential pathways.

METTL3 Knockdown Promotes Temozolomide Sensitivity of Glioma Stem Cells via Decreasing MGMT and APNG mRNA Stability

[Cell Death Discovery] Scientists found that the cell viability and half-maximal inhibitory concentration of glioma stem cells (GSCs) against temozolomide significantly decreased after GSCs underwent serum-induced differentiation to adherent growth of tumor cells.

Neural Cell News helps scientists keep pace with the latest research, reviews, and industry developments in neuroscience. Specific research topics include neural development and neuroregeneration, neural signaling related to cellular responses and behavior, and synaptic plasticity. Research into the diagnosis, progression, cellular characteristics, and treatment of brain diseases such as Parkinson’s, Multiple Sclerosis, Alzheimer’s, Amyotrophic Lateral Sclerosis and various brain cancers, as well as brain damage resulting from infection, trauma, stroke, seizures, and tumors, is also covered.