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Neural Cell News
Neural Cell News is an online resource covering the latest research in neuroscience, neural stem cells, and neurological conditions.
Brain Organoids Engineered to Give Rise to Glia and Neural Networks after 90 Days in Culture Exhibit Human-Specific Proteoforms
[Frontiers In Cellular Neuroscience] Scientists demonstrated that cell fate and composition of unguided brain organoids was dictated by culture conditions during embryoid body formation, and that culture conditions at this stage could be optimized to result in the presence of glia-associated proteins and neural network activity as early as three-months in vitro.
FAU Researchers Receive $1M in FDOH Grants to Fight Alzheimer’s Disease
[Florida Atlantic University] Three Florida Atlantic University researchers at the forefront of Alzheimer’s disease research have each received a $350,000 grant from the Florida Department of Health’s “Ed and Ethel Moore Alzheimer’s Disease Research Program.
AC Immune And Takeda Sign Exclusive Option And License Agreement For Active Immunotherapy Targeting Amyloid Beta For Alzheimer’s Disease
[AC Immune SA] Takeda and AC Immune SA announced a worldwide option and license agreement for AC Immune’s active immunotherapies targeting toxic forms of amyloid beta, including ACI-24.060 for the treatment of Alzheimer’s disease.
Salidroside Promotes the Repair of Spinal Cord Injury by Inhibiting Astrocyte Polarization, Promoting Neural Stem Cell Proliferation and Neuronal Differentiation
[Cell Death Discovery] Immunofluorescence-staining corroborated salidroside’s capacity to stimulate nerve regeneration and remyelination, suppress glial scar hyperplasia, reduce the activation of neurotoxic A1 astrocytes, and facilitate neural stem cells migration towards the injured region.
Itaconate Protects Ferroptotic Neurons by Alkylating GPx4 Post Stroke
[Cell Death & Differentiation] Deficiency of Irg1 or depletion of neuronal Irg1 in striatal neurons was shown to exaggerate neuronal loss and behavioral dysfunction in an intracerebral hemorrhage (ICH) mouse model using transgenic mice.
Cellular Senescence, DNA Damage, and Neuroinflammation in the Aging Brain
[Trends In Neurosciences] The authors synthesize accumulating evidence that age-related DNA damage and cellular senescence in the immune system and central nervous system contribute to the escalation of neuroinflammation and cognitive decline during normal brain aging.
CDKN2A/B Homozygous Deletion Sensitizes IDH-Mutant Glioma to CDK4/6 Inhibition
[Clinical Cancer Research] Scientists investigated the effect of CDK-Rb pathway blockade on isocitrate dehydrogenase (IDH)-mutant glioma growth in vitro and in vivo using CDK4/6 inhibitors.
Physiological Aging and Inflammation-Induced Cellular Senescence May Contribute to Oligodendroglial Dysfunction in MS
[Acta Neuropathologica] Using directly converted oligodendrocytes (dchiOL) from young, adult, and old human donors, the authors studied age-associated changes.
Actomyosin-II Protects Axons from Degeneration Induced by Mild Mechanical Stress
[Journal Of Cell Biology] Through pharmacological and molecular manipulations in vitro, the authors reported that actomyosin-II inactivation diminished the reversible beading process, fostered progressive Ca2+ spreading and thereby increased acute axonal degeneration in stressed axons.
Dr. Timothy Ryan Elected to National Academy of Sciences
[Weill Cornell Medicine] Dr. Timothy Ryan, professor of biochemistry in anesthesiology at Weill Cornell Medicine, has been elected to the National Academy of Sciences, one of the highest honors a scientist can receive.
Black Phosphorus Nanosheets Protect Neurons by Degrading Aggregative α-Syn and Clearing ROS in Parkinson’s Disease
[Advanced Materials] Black phosphorus nanosheets (BPNSs) interacted directly with α-synuclein (α-syn) fibrils to trigger their disaggregation for Parkinson's disease treatment. BPNSs were found to activate autophagy to maintain α-syn homeostasis, improve mitochondrial dysfunction, reduce reactive oxygen species levels, and rescue neuronal death and synaptic loss in PC12 cells.
Distinct Ultrastructural Phenotypes of Glial and Neuronal Alpha-Synuclein Inclusions in Multiple System Atrophy
[Brain] Correlative light and electron microscopy were employed to investigate alpha-synuclein pathology in the substantia nigra and putamen of post-mortem multiple system atrophy brain donors.
Neural Cell News helps scientists keep pace with the latest research, reviews, and industry developments in neuroscience. Specific research topics include neural development and neuroregeneration, neural signaling related to cellular responses and behavior, and synaptic plasticity. Research into the diagnosis, progression, cellular characteristics, and treatment of brain diseases such as Parkinson’s, Multiple Sclerosis, Alzheimer’s, Amyotrophic Lateral Sclerosis and various brain cancers, as well as brain damage resulting from infection, trauma, stroke, seizures, and tumors, is also covered.
