CNS Announces the FDA has Granted Orphan Drug Designation for Brain Cancer Drug Berubicin

CNS Pharmaceuticals, Inc. announced that the FDA has granted Orphan Drug Designation for its lead product Berubicin for the treatment of malignant gliomas.
[CNS Pharmaceuticals, Inc.]
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Sunovion Announces Health Canada Approval of KYNMOBI (Apomorphine Hydrochloride) Soluble Film for the Treatment of Parkinson’s Disease OFF Episodes

Sunovion Pharmaceuticals, Inc. announced that Health Canada has approved apomorphine HCI soluble film for the acute, intermittent treatment of OFF episodes in patients with Parkinson’s disease.
[Sunovion Pharmaceuticals, Inc.]
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Neurons That Regulate Mouse Torpor

Scientists showed that entry into mouse torpor, a fasting-induced state with a greatly decreased metabolic rate and a body temperature as low as 20 °C, was regulated by neurons in the medial and lateral preoptic area of the hypothalamus.
[Nature]
Hrvatin, S., Sun, S., Wilcox, O. F., Yao, H., Lavin-Peter, A. J., Cicconet, M., Assad, E. G., Palmer, M. E., Aronson, S., Banks, A. S., Griffith, E. C., & Greenberg, M. E. (2020). Neurons that regulate mouse torpor. Nature, 1–7. https://doi.org/10.1038/s41586-020-2387-5 Cite
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A Discrete Neuronal Circuit Induces a Hibernation-Like State in Rodents

Investigators showed that a hypothalamic neuronal circuit in rodents induced a long-lasting hypothermic and hypometabolic state similar to hibernation.
[Nature]
Takahashi, T. M., Sunagawa, G. A., Soya, S., Abe, M., Sakurai, K., Ishikawa, K., Yanagisawa, M., Hama, H., Hasegawa, E., Miyawaki, A., Sakimura, K., Takahashi, M., & Sakurai, T. (2020). A discrete neuronal circuit induces a hibernation-like state in rodents. Nature, 1–6. https://doi.org/10.1038/s41586-020-2163-6 Cite
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Novel Genetic Features of Human and Mouse Purkinje Cell Differentiation Defined by Comparative Transcriptomics

The authors identified genes expressed in human pluripotent stem cell-derived Purkinje cells (hPSC-PCs) and confirmed protein expression of a novel human PC gene, CD40LG, expressed in both hPSC-PCs and native human cerebellar tissue.
[Proceedings of the National Academy of Sciences of the United States of America]
Buchholz, D. E., Carroll, T. S., Kocabas, A., Zhu, X., Behesti, H., Faust, P. L., Stalbow, L., Fang, Y., & Hatten, M. E. (2020). Novel genetic features of human and mouse Purkinje cell differentiation defined by comparative transcriptomics. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.2000102117 Cite
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Impact of α-Synuclein Pathology on Transplanted hESC-Derived Dopaminergic Neurons in a Humanized α-Synuclein Rat Model of PD

Researchers established a humanized transplantation model of Parkinson’s disease that better recapitulates the main disease features, obtained by coinjection of preformed human α-synuclein (α-syn) fibrils and adeno-associated virus expressing human wild-type α-syn unilaterally into the rat substantia nigra.
[Proceedings of the National Academy of Sciences of the United States of America]
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Huge Open-Access Journal Deal Inked by University of California and Springer Nature

The University of California (UC) system announced it has signed the biggest open-access deal in North America with one of the largest commercial scientific publishers. The agreement with Springer Nature includes a commitment by the publisher to explore making all articles that UC corresponding authors publish in the Nature family of journals immediately free to read on publication starting in 2022.
[ScienceInsider]
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Dysregulation of BRD4 Function Underlies the Functional Abnormalities of MeCP2 Mutant Neurons

Scientists used 2D and 3D human brain cultures to investigate methyl-CpG binding protein 2 (MeCP2) function. They found that MeCP2 mutations caused severe abnormalities in human interneurons.
[Molecular Cell]
Dysregulation of BRD4 Function Underlies the Functional Abnormalities of MeCP2 Mutant Neurons: Molecular Cell. (n.d.). Retrieved June 12, 2020, from https://www.cell.com/molecular-cell/fulltext/S1097-2765(20)30317-8 Cite
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Toxoplasma gondii Infection Impairs Radial Glia Differentiation and Its Potential to Modulate Brain Microvascular Endothelial Cell Function in the Cerebral Cortex

Conditioned medium (CM) from Radial Glia (RG) control cultures increased ZO-1 protein levels and organization on endothelial bEnd.3 cells membranes, which was impaired by CM from infected RG, accompanied by decreased trans-endothelial electrical resistance.
[Microvascular Research]
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Pneumonia-Induced Endothelial Amyloids Reduce Dendritic Spine Density in Brain Neurons

Researchers used electrophysiological studies in brain slices and structural analysis of post-mortem tissues obtained from animals exposed to endothelium-derived amyloids. The amyloids were administered via three different routes, by intracerebroventricular, intratracheal, and intraperitoneal injections.
[Scientific Reports]
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Neural Metabolic Imbalance Induced by MOF Dysfunction Triggers Pericyte Activation and Breakdown of Vasculature

The authors showed that neural-specific depletion of three members of the non-specific lethal chromatin complex—Mof, Kansl2 or Kansl3—unexpectedly led to severe vascular defects and brain hemorrhaging.
[Nature Cell Biology]
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