Researchers introduced an integration-coupled On genetic switch, iOn, which triggered gene expression upon incorporation into the host genome through transposition, thus enabling rapid and accurate identification of integration events following transfection with naked plasmids.
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Investigators report an efficient one-step conversion of isolated mouse and human astrocytes to functional neurons by depleting the RNA-binding protein PTB.
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PARK2 knockout neurons exhibited a perturbed lysosomal morphology with enlarged electron-lucent lysosomes and an increased lysosomal content, which was exacerbated by mitochondrial stress and could be ameliorated by antioxidant treatment.
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Mitochon Pharmaceuticals announced that they, in partnership with the University of Kentucky and Children’s Hospital of Philadelphia, were awarded a $3.2M National Institutes of Health grant to study Mitochon’s mitochondrial targeted drug therapies for treating traumatic brain injury.
The authors present an overview of recent studies on the developmental origins, migratory properties, and morphology of chandelier cells.
[Trends in Neurosciences]
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Foundations that fund biomedical research in the United States, the United Kingdom, and elsewhere are reporting record revenue drops because of the pandemic. One major factor: It has forced them to cancel key fundraising events, including glitzy galas, sponsored walks, Broadway partnerships, and more.
Electrophysiological whole-cell voltage- and current-clamp recordings were performed on two control and three fragile X syndrome patient lines of human cortical neurons derived from iPSCs.
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Investigators showed that glioblastoma (GBM)‐initiating cells induced mTOR signaling in the microglia but not bone marrow‐derived macrophages in both in vitro and in vivo GBM mouse models.
lncRNA interactome, RNA immunoprecipitation, and coimmunoprecipitation studies identified BCR-mediated Ca+ signaling (BCALM)-interacting proteins in B cells, including phospholipase D 1, and kinase adaptor proteins AKAP9 and AKAP13.
[Journal of Immunology]
The authors identified the molecular mechanism of dysregulation of B cell subpopulations of primary Sjögren’s syndrome at the transcriptome level.
[Arthritis Research & Therapy]
Virtual lab tours are not new, but they have never been as common as in-person lab tours. However, the pandemic has generated strong incentives for formerly in-person lab tours to go online.