Direct Readout of Neural Stem Cell Transgenesis with an Integration-Coupled Gene Expression Switch

Researchers introduced an integration-coupled On genetic switch, iOn, which triggered gene expression upon incorporation into the host genome through transposition, thus enabling rapid and accurate identification of integration events following transfection with naked plasmids.
[Neuron]
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Reversing a Model of Parkinson’s Disease with In Situ Converted Nigral Neurons

Investigators report an efficient one-step conversion of isolated mouse and human astrocytes to functional neurons by depleting the RNA-binding protein PTB.
[Nature]
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Lysosomal Perturbations in Human Dopaminergic Neurons Derived from Induced Pluripotent Stem Cells with PARK2 Mutation

PARK2 knockout neurons exhibited a perturbed lysosomal morphology with enlarged electron-lucent lysosomes and an increased lysosomal content, which was exacerbated by mitochondrial stress and could be ameliorated by antioxidant treatment.
[Scientific Reports]
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University of Kentucky, Children’s Hospital of Philadelphia and Mitochon Pharmaceuticals Awarded NIH Grant for Traumatic Brain Injury Studies

Mitochon Pharmaceuticals announced that they, in partnership with the University of Kentucky and Children’s Hospital of Philadelphia, were awarded a $3.2M National Institutes of Health grant to study Mitochon’s mitochondrial targeted drug therapies for treating traumatic brain injury.
[Mitochon Pharmaceuticals]
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Shedding Light on Chandelier Cell Development, Connectivity, and Contribution to Neural Disorders

The authors present an overview of recent studies on the developmental origins, migratory properties, and morphology of chandelier cells.
[Trends in Neurosciences]
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COVID-19 Cancels Charity Galas and Walks. Science Is Paying the Price

Foundations that fund biomedical research in the United States, the United Kingdom, and elsewhere are reporting record revenue drops because of the pandemic. One major factor: It has forced them to cancel key fundraising events, including glitzy galas, sponsored walks, Broadway partnerships, and more.
[ScienceInsider]
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Cortical Neurons Derived from Human Pluripotent Stem Cells Lacking FMRP Display Altered Spontaneous Firing Patterns

Electrophysiological whole-cell voltage- and current-clamp recordings were performed on two control and three fragile X syndrome patient lines of human cortical neurons derived from iPSCs.
[Molecular Autism]
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Microglia Promote Glioblastoma via mTOR-Mediated Immunosuppression of the Tumor Microenvironment

Investigators showed that glioblastoma (GBM)‐initiating cells induced mTOR signaling in the microglia but not bone marrow‐derived macrophages in both in vitro and in vivo GBM mouse models.
[Embo Journal]
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BCALM (AC099524.1) Is a Human B Lymphocyte-Specific Long Noncoding RNA That Modulates B Cell Receptor–Mediated Calcium Signaling

lncRNA interactome, RNA immunoprecipitation, and coimmunoprecipitation studies identified BCR-mediated Ca+ signaling (BCALM)-interacting proteins in B cells, including phospholipase D 1, and kinase adaptor proteins AKAP9 and AKAP13.
[Journal of Immunology]
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Identification of Novel Genes Associated with Dysregulation of B Cells in Patients with Primary Sjögren’s Syndrome

The authors identified the molecular mechanism of dysregulation of B cell subpopulations of primary Sjögren’s syndrome at the transcriptome level.
[Arthritis Research & Therapy]
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Virtual Lab Tours for Recruitment and Outreach

Virtual lab tours are not new, but they have never been as common as in-person lab tours. However, the pandemic has generated strong incentives for formerly in-person lab tours to go online.
[The Scientist]
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