Neural Cell News

Neural Cell News is an online resource covering the latest research in neuroscience, neural stem cells, and neurological conditions.

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The Diverse Forms and Roles of the Neuronal Endoplasmic Reticulum

January 21, 2026

[Nature Reviews Neuroscience] Investigators highlighted how neuronal endoplasmic reticulum morphology is established in different subcellular domains, including somato-dendritic regions, axons, and presynaptic and postsynaptic sites.

NeuraLight and Teitur Trophics Announce Collaboration to Use Precision Biomarkers in TT-P34 Parkinson’s Disease Clinical Trial

January 21, 2026

[NeuraLight] NeuraLight announced that they have entered into a collaboration granting Teitur Trophics access to NeuraLight’s brain function biomarker platform for use in its upcoming clinical trial of TT-P34 in Parkinson’s disease.

Highly Endowed Research Award for DKFZ Scientist

January 21, 2026

[DKFZ] Daniel Kirschenbaum from the German Cancer Research Center (DKFZ) is developing new methods to find out exactly how immune cells are suppressed by malignant brain tumors. He is being supported in this by the EACR-Mark Foundation and the Pezcoller Foundation with the Rising Star Award.

Aging Promotes Microglial Accumulation of Slow-Degrading Synaptic Proteins

January 21, 2026

[Nature] The authors reported that neuronal protein half-life approximately doubles on average between 4-month-old and 24-month-old mice, with the stability of individual proteins differing among brain regions.

The Therapeutic Potential and Mechanisms of Targeting the PTBP1/Nogo-A/NgR Axis in PTSD Induced by Single Prolonged Stress in Mice

January 21, 2026

[Experimental & Molecular Medicine] Scientists elucidate the neurorestorative effects of modulating the PTBP1/Nogo-A/NgR axis in a mouse model of post-traumatic stress disorder established through the single prolonged stress paradigm, and the mechanisms were further investigated through a series of experiments including pathological and molecular detection.

A Transposase-Derived Gene Required for Human Brain Development

January 20, 2026

[Science Advances] Scientists showed that PiggyBac transposable element derived 5 contributes to normal brain development in mice and humans, and its deficiency causes disorder of intellectual disability, movement disorders, and epilepsy.

Evolution of the Lipidome Uncovers Early Changes in Adrenoleukodystrophy Human Cortical and Spinal Organoids

January 20, 2026

[Iscience] To investigate lipid dynamics in central nervous system development and adrenoleukodystrophy pathogenesis, scientists generated hiPSC-derived cortical and spinal cord organoids and performed lipidomics over 200 days.

Single-Cell Atlas of the Developing Down Syndrome Brain Cortex

January 20, 2026

[Nature Medicine] Researchers performed single-cell transcriptomic and chromatin accessibility profiling of approximately 250,000 cells from 15 Down syndrome (DS) and 15 control human fetal cortices. Their analysis revealed a subtype-specific reduction in RORB/FOXP1-expressing excitatory neurons and disruption of neurodevelopmental transcriptional programs.

Imaging Spatial Transcriptomics Reveals Molecular Patterns Underlying Accumulation of P-Ser129 α-Synuclein in a Transgenic Mouse Model

January 20, 2026

[NPJ Parkinson'S Disease] Researchers identified neuronal subtypes in the cortex and hippocampus of transgenic human α-synuclein-overexpressing mice that preferentially developed α-synuclein phosphorylated at Ser129 accumulation.

Epigenetic Treatment of Synaptic and Behavioral Deficits in Dyrk1a-Mutant Mice

January 20, 2026

[Neuropsychopharmacology] Using a mouse model carrying mutated Dyrk1a, Dyrkmut, researchers demonstrated the alteration of synaptic genes and synaptic functions in prefrontal cortex, as well as the manifestation of autism-related behaviors.

A Prefrontal Cortex Map Based on Single-Neuron Activity

January 20, 2026

[Nature Neuroscience] Researchers profiled the activity and spatial location of >24,000 neurons recorded in awake mice.

Calcium Overload Induced Mitochondrial and Lysosomal Dysfunction Is Regulated by Tousled-Like Kinase in A-Synucleinopathy

January 8, 2026

[Cell Death & Disease] Researchers found that calcium overload caused mitochondrial damage and lysosomal dysfunction, leading to cell death, and these cytotoxic processes were significantly mitigated by the loss of Tousled-like kinase.

Neural Cell News helps scientists keep pace with the latest research, reviews, and industry developments in neuroscience. Specific research topics include neural development and neuroregeneration, neural signaling related to cellular responses and behavior, and synaptic plasticity. Research into the diagnosis, progression, cellular characteristics, and treatment of brain diseases such as Parkinson’s, Multiple Sclerosis, Alzheimer’s, Amyotrophic Lateral Sclerosis and various brain cancers, as well as brain damage resulting from infection, trauma, stroke, seizures, and tumors, is also covered.