Cancer Stem Cell News Volume 11.28 | Jul 20 2022


    2022-07-20 | CSCN 11.28

    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 11.28 – 20 July, 2022

    ZMYND8 Is a Master Regulator of 27-Hydroxycholesterol that Promotes Tumorigenicity of Breast Cancer Stem Cells

    Using genetic mouse mammary tumor and human breast cancer models, researchers showed that the histone reader ZMYND8 was selectively expressed in breast CSCs (BCSCs) and promoted epithelial-mesenchymal transition, BCSC maintenance and self-renewal, and oncogenic transformation through its epigenetic functions, leading to breast tumor initiation.
    [Science Advances]

    Full Article
    PUBLICATIONSRanked by the impact factor of the journal

    β2-Microglobulin Maintains Glioblastoma Stem Cells and Induces M2-Like Polarization of Tumor-Associated Macrophages

    Investigators demonstrated that β2-microglobulin promoted maintenance of stem-like neoplastic populations and reprogramed the tumor immune microenvironment to an anti-inflammatory, tumor-promoting state.
    [Cancer Research]


    Assessment of the Association of OCT3/4 with GLUT1 and CD105 in Oral Squamous Cell Carcinoma Using Dual Immunohistochemistry

    The authors investigated the role of CSCs in angiogenesis and hypoxic response in oral squamous cell carcinoma.
    [BMC Oral Health]

    Full Article

    FZD7 Accelerates Hepatic Metastases in Pancreatic Cancer by Strengthening EMT and Stemness Associated with TGF-β/SMAD3 Signaling

    The expression of Frrizled receptor 7 in pancreatic ductal adenocarcinoma and relating survival rate were analyzed by bioinformatics, histochemistry assay and follow-up study.
    [Molecular Medicine]

    Full Article

    A Brain Precursor Atlas Reveals the Acquisition of Developmental-Like States in Adult Cerebral Tumors

    Scientists mapped the development of mouse cerebrum across the developmental time-course, from embryonic day 12.5 to postnatal day 365, performing single-cell transcriptomics on over 100,000 cells.
    [Nature Communications]

    Full Article

    Comprehensive Computational Analysis of Honokiol Targets for Cell Cycle Inhibition and Immunotherapy in Metastatic Breast Cancer Stem Cells

    The authors explored the potential targets and molecular mechanisms of honokiol on metastatic breast CSC-cell cycle arrest and the impact of the tumor microenvironment.
    [Evidence-Based Complementary and Alternative Medicine]


    The Abnormal Expression of Circ-ARAP2 Promotes ESCC Progression through Regulating miR-761/FOXM1 Axis-Mediated Stemness and the Endothelial–Mesenchymal Transition

    circRNAs differentially expressed in esophageal squamous cell carcinoma and adjacent normal tissues were characterized via high-throughput sequencing.
    [Journal of Translational Medicine]

    Full Article

    Lysosomal Protein Transmembrane 5 Promotes Lung-Specific Metastasis by Regulating BMPR1A Lysosomal Degradation

    Researchers showed that lysosomal protein transmembrane 5 promoted lung-specific metastasis in renal cancer.
    [Nature Communications]


    Analysis of Copy Number Alterations in Bladder Cancer Stem Cells Revealed a Prognostic Role of LRP1B

    Investigators analyzed copy-number alterations of selected genes in our cohorts of CSCs and in The Cancer Genome Atlas cohort with the aim to correlate their frequency with patients’ prognosis.
    [World Journal of Urology]

    Full Article

    Stem Cells in the Tumor Immune Microenvironment – Part of the Cure or Part of the Disease? Ontogeny and Dichotomy of Stem and Immune Cells Has Led to Better Understanding

    Scientists review the most relevant interactions carried out between the stem cells, tumor cells and immune cells in a bottom-up incursion through the tumor microenvironment beginning from the perivascular niche and going through the tumoral parenchyma and the related stroma.
    [Stem Cell Reviews and Reports]

    Full Article

    Exclusive: Investigators Found Plagiarism and Data Falsification in Work from Prominent Cancer Lab

    Ohio State University investigations identified misconduct by two scientists in lab of high-profile cancer researcher Carlo Croce. The university has cleared Croce of misconduct, but disciplined him over management problems.
    [Nature News]

    Press Release

    Israel and UAE to Collaborate on Cancer and Diabetes Research

    Israel and the UAE have signed an agreement to promote cancer and diabetes research, in addition to a joint study on mass vitamin D deficiency in the region.
    [Middle East Monitor]

    Press Release

    The Neuro-Immune Axis

    September 11 – 13, 2022
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    Postdoctoral Scholar – Protein Degradation in Cancer and Alzheimer’s

    Virginia Commonwealth University – Richmond, Virginia, United States

    Principal Scientist – Cancer Immunology Drug Discovery

    Boehringer Ingelheim – Vienna, Austria

    Associate Professor – Thematic Research Programs

    The Chinese University of Hong Kong – Hong Kong, China

    Research Officer – Cancer Research

    Children’s Medical Research Institute – Sydney, Australia

    Postdoctoral Positions – Tumor Metabolism

    Université catholique de Louvain – Brussels, Belgium

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