 | | Vol. 11.28 – 20 July, 2022 |
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| Using genetic mouse mammary tumor and human breast cancer models, researchers showed that the histone reader ZMYND8 was selectively expressed in breast CSCs (BCSCs) and promoted epithelial-mesenchymal transition, BCSC maintenance and self-renewal, and oncogenic transformation through its epigenetic functions, leading to breast tumor initiation.
[Science Advances] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators demonstrated that β2-microglobulin promoted maintenance of stem-like neoplastic populations and reprogramed the tumor immune microenvironment to an anti-inflammatory, tumor-promoting state.
[Cancer Research] |
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| The authors investigated the role of CSCs in angiogenesis and hypoxic response in oral squamous cell carcinoma.
[BMC Oral Health] |
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| The expression of Frrizled receptor 7 in pancreatic ductal adenocarcinoma and relating survival rate were analyzed by bioinformatics, histochemistry assay and follow-up study.
[Molecular Medicine] |
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| Scientists mapped the development of mouse cerebrum across the developmental time-course, from embryonic day 12.5 to postnatal day 365, performing single-cell transcriptomics on over 100,000 cells.
[Nature Communications] |
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| The authors explored the potential targets and molecular mechanisms of honokiol on metastatic breast CSC-cell cycle arrest and the impact of the tumor microenvironment.
[Evidence-Based Complementary and Alternative Medicine] |
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| circRNAs differentially expressed in esophageal squamous cell carcinoma and adjacent normal tissues were characterized via high-throughput sequencing.
[Journal of Translational Medicine] |
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| Researchers showed that lysosomal protein transmembrane 5 promoted lung-specific metastasis in renal cancer.
[Nature Communications] |
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| Investigators analyzed copy-number alterations of selected genes in our cohorts of CSCs and in The Cancer Genome Atlas cohort with the aim to correlate their frequency with patients’ prognosis.
[World Journal of Urology] |
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| Scientists review the most relevant interactions carried out between the stem cells, tumor cells and immune cells in a bottom-up incursion through the tumor microenvironment beginning from the perivascular niche and going through the tumoral parenchyma and the related stroma.
[Stem Cell Reviews and Reports] |
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| Ohio State University investigations identified misconduct by two scientists in lab of high-profile cancer researcher Carlo Croce. The university has cleared Croce of misconduct, but disciplined him over management problems.
[Nature News] |
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| Israel and the UAE have signed an agreement to promote cancer and diabetes research, in addition to a joint study on mass vitamin D deficiency in the region.
[Middle East Monitor] |
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| September 11 – 13, 2022
Lisbon, Portugal |
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| | Virginia Commonwealth University – Richmond, Virginia, United States |
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| | Boehringer Ingelheim – Vienna, Austria |
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| | The Chinese University of Hong Kong – Hong Kong, China |
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| | Children’s Medical Research Institute – Sydney, Australia |
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| | Universit̩ catholique de Louvain РBrussels, Belgium |
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