 | | Vol. 11.34 – 21 September, 2022 |
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| Investigators document the secretory role of endothelial cells and their derived extracellular vesicles as drivers of proneural-to-mesenchymal reprogramming of glioma stem cells.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Knockdown of SerpinB3 increased apoptosis and susceptibility to radiation therapy, and scientists found that SerpinB3 was essential to buffer cathepsin L-mediated cell death.
[Cell Reports] |
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| In models of cutaneous squamous cell carcinoma, investigators discovered a non-epithelial-mesenchymal transition function for the transcription factor Snail in maintaining the stemness of epidermal keratinocytes.
[Cell Reports] |
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| Combining radiated UM-Chor1 RNA-seq data and in vitro validation, researchers found clusters of stem-like skull base chordoma cells were marked by cathepsin L, a gene involved in the packaging of telomere ends, and which may be responsible for radioresistance.
[Cell Discovery] |
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| The authors explored the blockage of chemokine receptor CCR3 in carcinoma cell lines and found that inhibition of CCR3 induced the formation of polyploid giant cells and stabilization of β-catenin via the PI3K/Akt/GSK-3β signaling pathway.
[Cancer Gene Therapy] |
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| Investigators assessed prostaglandin E2 (PGE2) as a candidate for incudcing CSCs from induced pluripotent stem cells (iPSCs), and chronic stimulation of the receptors EP-2/4 by PGE2 was supposed to induce CSCs from iPSCs through epigenetic effect.
[Scientific Reports] |
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| Researchers demonstrated that β-catenin is regulated by the protein degradation system in mesenchymal spheroid-forming cells and secondary epithelial ovarian cancer cells, but not in primary epithelial ovarian cancer cells.
[Scientific Reports] |
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| The expression gradient of four genes related to CSCs and their potential regulatory microRNAs were investigated in the central part and invasive front of the primary tumor, as well as in lymph node and liver metastases.
[Oncology Reports] |
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| Scientists investigated the effect of disulfiram and copper (II) D-gluconate on the radiosensitivity of esophageal squamous cell carcinoma in xenograft mouse models.
[Esophagus] |
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| The authors provide recent findings on the role of ncRNAs in glioma development and progression, particularly their effects on cancer stem cells.
[Molecular Therapy Oncolytics] |
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| Virogin Biotech and The University of Texas MD Anderson Cancer Center announced a strategic collaboration to accelerate the development of investigational treatments, including oncolytic viruses and immunotherapies, for patients with advanced cancers.
[Virogin Biotech] |
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| October 10 – 12, 2022
Lausanne, Switzerland |
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| | Netherlands Cancer Institute (AVL) – Amsterdam, Netherlands |
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| | The Jackson Laboratory – Bar Harbor, Maine, United States |
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| | Michigan State University – East Lansing, Michigan, United States |
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| | Stanford Medicine – Stanford, California, United States |
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| | The University Health Network – Toronto, Ontario, Canada |
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