Cancer Stem Cell News Volume 11.34 | Sep 21 2022

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    2022-09-21 | CSCN 11.34


    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 11.34 – 21 September, 2022
    TOP STORY

    Angiocrine Extracellular Vesicles Impose Mesenchymal Reprogramming upon Proneural Glioma Stem Cells

    Investigators document the secretory role of endothelial cells and their derived extracellular vesicles as drivers of proneural-to-mesenchymal reprogramming of glioma stem cells.
    [Nature Communications]

    Full Article
    Webinar on Modeling arrhythmias using hPSC-derived cardiomyocytes
    PUBLICATIONSRanked by the impact factor of the journal

    SerpinB3 Drives Cancer Stem Cell Survival in Glioblastoma

    Knockdown of SerpinB3 increased apoptosis and susceptibility to radiation therapy, and scientists found that SerpinB3 was essential to buffer cathepsin L-mediated cell death.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Snail Maintains the Stem/Progenitor State of Skin Epithelial Cells and Carcinomas through the Autocrine Effect of Matricellular Protein Mindin

    In models of cutaneous squamous cell carcinoma, investigators discovered a non-epithelial-mesenchymal transition function for the transcription factor Snail in maintaining the stemness of epidermal keratinocytes.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Single-Cell Transcriptome Reveals Cellular Hierarchies and Guides P-EMT-Targeted Trial in Skull Base Chordoma

    Combining radiated UM-Chor1 RNA-seq data and in vitro validation, researchers found clusters of stem-like skull base chordoma cells were marked by cathepsin L, a gene involved in the packaging of telomere ends, and which may be responsible for radioresistance.
    [Cell Discovery]

    Full Article

    CCR3 Blockage Elicits Polyploidization Associated with the Signatures of Epithelial-Mesenchymal Transition in Carcinoma Cell Lines

    The authors explored the blockage of chemokine receptor CCR3 in carcinoma cell lines and found that inhibition of CCR3 induced the formation of polyploid giant cells and stabilization of β-catenin via the PI3K/Akt/GSK-3β signaling pathway.
    [Cancer Gene Therapy]

    Abstract

    Cancer Stem Cells Induced by Chronic Stimulation with Prostaglandin E2 Exhibited Constitutively Activated PI3K Axis

    Investigators assessed prostaglandin E2 (PGE2) as a candidate for incudcing CSCs from induced pluripotent stem cells (iPSCs), and chronic stimulation of the receptors EP-2/4 by PGE2 was supposed to induce CSCs from iPSCs through epigenetic effect.
    [Scientific Reports]

    Full Article

    TWIST1 Induces Proteasomal Degradation of β-Catenin During the Differentiation of Ovarian Cancer Stem-Like Cells

    Researchers demonstrated that β-catenin is regulated by the protein degradation system in mesenchymal spheroid-forming cells and secondary epithelial ovarian cancer cells, but not in primary epithelial ovarian cancer cells.
    [Scientific Reports]

    Full Article

    Intra-Tumor Heterogeneity of Cancer Stem Cell-Related Genes and Their Potential Regulatory MicroRNAs in Metastasizing Colorectal Carcinoma

    The expression gradient of four genes related to CSCs and their potential regulatory microRNAs were investigated in the central part and invasive front of the primary tumor, as well as in lymph node and liver metastases.
    [Oncology Reports]

    Abstract

    An Anti-Alcoholism Drug, Disulfiram and Copper Complex Improves Radio-Resistance of Tumor-Initiating Cells in Esophageal Squamous Cell Carcinoma

    Scientists investigated the effect of disulfiram and copper (II) D-gluconate on the radiosensitivity of esophageal squamous cell carcinoma in xenograft mouse models.
    [Esophagus]

    Full Article
    Are Your Pluripotent Stem Cells What You Think They Are? Explore Now.
    REVIEWS

    Non-Coding RNAs and Glioma: Focus on Cancer Stem Cells

    The authors provide recent findings on the role of ncRNAs in glioma development and progression, particularly their effects on cancer stem cells.
    [Molecular Therapy Oncolytics]

    Abstract
    Full ArticleGraphical Abstract
    INDUSTRY AND POLICY NEWS

    Virogin Biotech and MD Anderson Announce Strategic Collaboration to Accelerate Oncolytic Virus Research and Development for Treating Advanced Cancers

    Virogin Biotech and The University of Texas MD Anderson Cancer Center announced a strategic collaboration to accelerate the development of investigational treatments, including oncolytic viruses and immunotherapies, for patients with advanced cancers.
    [Virogin Biotech]

    Press Release
    FEATURED EVENT

    Preclinical and Personalized Breast Cancer Research: Preclinical Models Course

    October 10 – 12, 2022
    Lausanne, Switzerland

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Researcher – Bioinformatics, mRNA Translation in Cancer

    Netherlands Cancer Institute (AVL) – Amsterdam, Netherlands

    Postdoctoral Associate – Aging Hematopoiesis

    The Jackson Laboratory – Bar Harbor, Maine, United States

    Associate Professor – Solid Cancer Tumor Development

    Michigan State University – East Lansing, Michigan, United States

    Postdoctoral Researcher – Cancer and Stem Cell Biology

    Stanford Medicine – Stanford, California, United States

    Postdoctoral Fellow – Cancer Biology & Imaging

    The University Health Network – Toronto, Ontario, Canada

    > See All Jobs

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