Cancer Stem Cell News Volume 11.16 | Apr 27 2022

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    2022-04-27 | CSCN 11.16


    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 11.16 – 27 April, 2022
    TOP STORY

    Intrinsic Role of Chaperone-Mediated Autophagy in Cancer Stem Cell Maintenance

    Scientists revealed a novel function of chaperone-mediated autophagy as an intrinsic regulator of glioma stem cell tumorigenic properties and highlighted its relevance in glioblastoma progression.
    [Autophagy]

    Abstract

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    PUBLICATIONSRanked by the impact factor of the journal

    Exosomal miR-4466 from Nicotine-Activated Neutrophils Promotes Tumor Cell Stemness and Metabolism in Lung Cancer Metastasis

    The authors examined the mechanism by which nicotine promoted lung cancer brain metastasis. They conducted a retrospective analysis of 810 lung cancer patients with a smoking history and assessed brain metastasis.
    [Oncogene]

    Full Article

    Targeting DRD2 by the Antipsychotic Drug, Penfluridol, Retards Growth of Renal Cell Carcinoma via Inducing Stemness Inhibition and Autophagy-Mediated Apoptosis

    Researchers uncovered penfluridol suppressed in vitro cell growth and in vivo tumorigenicity of various renal cell carcinoma (RCC) cell lines and enhanced the Sutent-triggered growth inhibition on clear cell RCC cell lines.
    [Cell Death & Disease]

    Full Article

    Mitochondrial Oxidative Phosphorylation Is Dispensable for Survival of CD34+ Chronic Myeloid Leukemia Stem and Progenitor Cells

    Scientists compared the signature of CD34+ stem/progenitor cells collected from chronic myeloid leukemia individuals with that of healthy donors and observed significant changes in the abundance of enzymes associated with aerobic central carbonate metabolic pathways.
    [Cell Death & Disease]

    Full Article

    Dynamic Expression of Schlafen 11 (SLFN11) in Circulating Tumor Cells as a Liquid Biomarker in Small Cell Lung Cancer

    SLFN11 expression was evaluated in tumor samples and characterized in circulating tumor cells (CTC) longitudinally to determine its potential role as a biomarker of response.
    [British Journal of Cancer]

    Abstract

    ANGPTL1 Attenuates Cancer Migration, Invasion, and Stemness through Regulating FOXO3a-Mediated SOX2 Expression in Colorectal Cancer

    The authors demonstrated that the molecular mechanisms of angiopoietin-like protein 1 (ANGPTL1) in colorectal CSC progression may have provided a novel therapeutic strategy for colorectal cancer.
    [Clinical Science]

    AbstractFull Article

    Liver Tumor-Initiating Cells Initiate the Formation of a Stiff Cancer Stem Cell Microenvironment Niche by Secreting LOX

    Researchers reported that the voltage-gated calcium channel α2δ1 subunit-positive tumor-initiating cells of hepatocellular carcinoma specifically secreted LOX, forming a stiff extracellular matrix that was sufficient to drive the formation of tumor-initiating cells with a stiff mechanical trait.
    [Carcinogenesis]

    Abstract

    Graphical Abstract

    Tumor Stem Cell-Derived Exosomal microRNA-17-5p Inhibits Anti-Tumor Immunity in Colorectal Cancer via Targeting SPOP and Overexpressing PD-L1

    Investigators explored the effect of colorectal cancer (CRC) stem cells-derived exosomes conveying miR-17-5p on CRC.
    [Cell Death Discovery]

    Full Article

    Dipyridophenazine Iridium(III) Complex as a Phototoxic Cancer Stem Cell Selective, Mitochondria Targeting Agent

    The remarkable activity of complex 1 was observed not only in rhabdomyosarcoma cells cultured in 2D monolayers but, more importantly, also in 3D spheroids, which resembled in many aspects solid tumors and served as a promising model to mimic the in vivo situation.
    [Chemico-Biological interactions]

    AbstractGraphical Abstract

    Colorectal Cancer Stem Cell-Derived Exosomal Long Intergenic Noncoding RNA 01315 (LINC01315) Promotes Proliferation, Migration, and Stemness of Colorectal Cancer Cells

    The viability, proliferation, stemness, and migration of CD133+/CD44+, CD133/CD44, and colorectal cancer cells after transfection or the co-culture with exosomes were detected by MTT, colony formation, spheroid, and wound healing assays, respectively.
    [Bioengineered]

    Full ArticleGraphical Abstract

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    REVIEWS

    Mechanism of Cancer Stemness Maintenance in Human Liver Cancer

    Scientists evaluate the mechanism of cancer stemness maintenance of liver cancer stem cells (LCSCs) and discuss promising treatments for eradicating LCSCs.
    [Cell Death & Disease]

    Full Article

    INDUSTRY AND POLICY NEWS

    Allogene Therapeutics Receives FDA Orphan-Drug Designation for ALLO-605, Its First TurboCAR™ T Cell Product Candidate, for the Treatment of Multiple Myeloma

    Allogene Therapeutics, Inc. announced that the US FDA has granted orphan-drug designation to ALLO-605, the company’s next-generation allogenic CAR T product candidate targeting BCMA for the treatment of multiple myeloma.
    [Allogene Therapeutics, Inc.]

    Press Release

    FEATURED EVENT

    ISCT – JSTCT Joint Session at the 44th JSTCT Annual Meeting (JSTCT 2022)

    May 12 – May 14, 2022
    Yokohama, Japan

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Position – Gynecologic Cancer

    Johns Hopkins University – Baltimore, Maryland, United States

    Associate Professor – Cancer Immunology

    McGill University – Montreal, Quebec, Canada

    Scientific Director – Cancer Research

    Cyprus Cancer Research Institute – Nicosia, Cyprus

    Tenure-Track Associate Professor – Stem Cell Biology

    The University of Hong Kong – Hong Kong, China

    Postdoctoral Position – Tumor Heterogeneity

    Luxembourg Institute of Health – Strassen, Luxembourg

    > See All Jobs

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