Cancer Stem Cell News Volume 11.16 | Apr 27 2022


    2022-04-27 | CSCN 11.16

    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 11.16 – 27 April, 2022

    Intrinsic Role of Chaperone-Mediated Autophagy in Cancer Stem Cell Maintenance

    Scientists revealed a novel function of chaperone-mediated autophagy as an intrinsic regulator of glioma stem cell tumorigenic properties and highlighted its relevance in glioblastoma progression.


    PUBLICATIONSRanked by the impact factor of the journal

    Exosomal miR-4466 from Nicotine-Activated Neutrophils Promotes Tumor Cell Stemness and Metabolism in Lung Cancer Metastasis

    The authors examined the mechanism by which nicotine promoted lung cancer brain metastasis. They conducted a retrospective analysis of 810 lung cancer patients with a smoking history and assessed brain metastasis.

    Full Article

    Targeting DRD2 by the Antipsychotic Drug, Penfluridol, Retards Growth of Renal Cell Carcinoma via Inducing Stemness Inhibition and Autophagy-Mediated Apoptosis

    Researchers uncovered penfluridol suppressed in vitro cell growth and in vivo tumorigenicity of various renal cell carcinoma (RCC) cell lines and enhanced the Sutent-triggered growth inhibition on clear cell RCC cell lines.
    [Cell Death & Disease]

    Full Article

    Mitochondrial Oxidative Phosphorylation Is Dispensable for Survival of CD34+ Chronic Myeloid Leukemia Stem and Progenitor Cells

    Scientists compared the signature of CD34+ stem/progenitor cells collected from chronic myeloid leukemia individuals with that of healthy donors and observed significant changes in the abundance of enzymes associated with aerobic central carbonate metabolic pathways.
    [Cell Death & Disease]

    Full Article

    Dynamic Expression of Schlafen 11 (SLFN11) in Circulating Tumor Cells as a Liquid Biomarker in Small Cell Lung Cancer

    SLFN11 expression was evaluated in tumor samples and characterized in circulating tumor cells (CTC) longitudinally to determine its potential role as a biomarker of response.
    [British Journal of Cancer]


    ANGPTL1 Attenuates Cancer Migration, Invasion, and Stemness through Regulating FOXO3a-Mediated SOX2 Expression in Colorectal Cancer

    The authors demonstrated that the molecular mechanisms of angiopoietin-like protein 1 (ANGPTL1) in colorectal CSC progression may have provided a novel therapeutic strategy for colorectal cancer.
    [Clinical Science]

    AbstractFull Article

    Liver Tumor-Initiating Cells Initiate the Formation of a Stiff Cancer Stem Cell Microenvironment Niche by Secreting LOX

    Researchers reported that the voltage-gated calcium channel α2δ1 subunit-positive tumor-initiating cells of hepatocellular carcinoma specifically secreted LOX, forming a stiff extracellular matrix that was sufficient to drive the formation of tumor-initiating cells with a stiff mechanical trait.


    Graphical Abstract

    Tumor Stem Cell-Derived Exosomal microRNA-17-5p Inhibits Anti-Tumor Immunity in Colorectal Cancer via Targeting SPOP and Overexpressing PD-L1

    Investigators explored the effect of colorectal cancer (CRC) stem cells-derived exosomes conveying miR-17-5p on CRC.
    [Cell Death Discovery]

    Full Article

    Dipyridophenazine Iridium(III) Complex as a Phototoxic Cancer Stem Cell Selective, Mitochondria Targeting Agent

    The remarkable activity of complex 1 was observed not only in rhabdomyosarcoma cells cultured in 2D monolayers but, more importantly, also in 3D spheroids, which resembled in many aspects solid tumors and served as a promising model to mimic the in vivo situation.
    [Chemico-Biological interactions]

    AbstractGraphical Abstract

    Colorectal Cancer Stem Cell-Derived Exosomal Long Intergenic Noncoding RNA 01315 (LINC01315) Promotes Proliferation, Migration, and Stemness of Colorectal Cancer Cells

    The viability, proliferation, stemness, and migration of CD133+/CD44+, CD133/CD44, and colorectal cancer cells after transfection or the co-culture with exosomes were detected by MTT, colony formation, spheroid, and wound healing assays, respectively.

    Full ArticleGraphical Abstract

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    Mechanism of Cancer Stemness Maintenance in Human Liver Cancer

    Scientists evaluate the mechanism of cancer stemness maintenance of liver cancer stem cells (LCSCs) and discuss promising treatments for eradicating LCSCs.
    [Cell Death & Disease]

    Full Article


    Allogene Therapeutics Receives FDA Orphan-Drug Designation for ALLO-605, Its First TurboCAR™ T Cell Product Candidate, for the Treatment of Multiple Myeloma

    Allogene Therapeutics, Inc. announced that the US FDA has granted orphan-drug designation to ALLO-605, the company’s next-generation allogenic CAR T product candidate targeting BCMA for the treatment of multiple myeloma.
    [Allogene Therapeutics, Inc.]

    Press Release


    ISCT – JSTCT Joint Session at the 44th JSTCT Annual Meeting (JSTCT 2022)

    May 12 – May 14, 2022
    Yokohama, Japan

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    Postdoctoral Position – Gynecologic Cancer

    Johns Hopkins University – Baltimore, Maryland, United States

    Associate Professor – Cancer Immunology

    McGill University – Montreal, Quebec, Canada

    Scientific Director – Cancer Research

    Cyprus Cancer Research Institute – Nicosia, Cyprus

    Tenure-Track Associate Professor – Stem Cell Biology

    The University of Hong Kong – Hong Kong, China

    Postdoctoral Position – Tumor Heterogeneity

    Luxembourg Institute of Health – Strassen, Luxembourg

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