 | | Vol. 23.17 – 16 May, 2022 |
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Cytosine Base Editing Enables Quadruple-Edited Allogeneic CAR-T Cells for T-ALL | Cytosine base editors installed C•G to T•A point mutations in T cells with between 90-99% efficiency to silence gene expression without creating double-stranded breaks, greatly reducing or eliminating undesired editing outcomes following multiplexed editing as compared to CRISPR-Cas9.
[Blood] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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FasL Microgels Induce Immune Acceptance of Islet Allografts in Nonhuman Primates | Investigators reported a strategy through which cotransplantation of allogeneic islets and streptavidin–FasL–presenting microgels to the omentum under transient rapamycin monotherapy resulted in robust glycemic control, sustained C-peptide levels, and graft survival in diabetic nonhuman primates for over six months.
[Science Advances] |
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Off-the-Shelf CAR Natural Killer Cells Secreting IL-15 Target Spike in Treating COVID-19 | Scientists showed engineering of NK cells to express soluble interleukin-15 for enhancing their survival and a CAR consisting of an extracellular domain of ACE2, targeting the spike protein of SARS-CoV-2.
[Nature Communications] |
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Locally Secreted BiTEs Complement CAR T Cells by Enhancing Killing of Antigen Heterogeneous Solid Tumors | Scientists detected expression of tumor-associated epidermal growth factor receptor (EGFR), EGFR variant III, and interleukin-13 receptor alpha 2 on glioma tissues and cancer stem cells.
[Molecular Therapy] |
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Rescue of Behavioral and Electrophysiological Phenotypes in a Pitt-Hopkins Syndrome Mouse Model by Genetic Restoration of Tcf4 Expression | Investigators performed proof-of-concept viral gene therapy experiments using a conditional Tcf4 mouse model of Pitt-Hopkins syndrome and found that postnatally reinstating Tcf4 expression in neurons improved anxiety-like behavior, activity levels, innate behaviors, and memory.
[eLife] |
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Reestablishment of Spermatogenesis after More than 20 Years of Cryopreservation of Rat Spermatogonial Stem Cells Reveals an Important Impact in Differentiation Capacity | The authors demonstrated that rat spermatogonial stem cells frozen for more than 20 years can be transplanted into recipient mice and produce all differentiating germ cell types.
[PLoS Biology] |
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Conductive Nanocomposite Hydrogel and Mesenchymal Stem Cells for the Treatment of Myocardial Infarction and Non-Invasive Monitoring via Pet/Ct | The combination of MSCs and the injectable conductive nanocomposite hydrogel offered a promising strategy for myocardial infarction treatment.
[Journal of Nanobiotechnology] |
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Adipose Mesenchymal Stem Cell-Based Tissue Engineering Mesh with Sustained bFGF Release to Enhance Tissue Repair | Investigators used coaxial electrospinning technology to achieve local basic fibroblast growth factor release to promote regeneration. Adipose-derived stem cells were loaded to demonstrate their paracrine ability of immune regulation and angiogenesis.
[Biomaterials Science] |
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Mesh-Like Electrospun Membrane Loaded with Atorvastatin Facilitates Cutaneous Wound Healing by Promoting the Paracrine Function of Mesenchymal Stem Cells | Scientists established a rat model of wound healing, applied atorvastatin -loaded mesh-like membranes seeded with bone marrow-derived MSCs on wounds, and assessed their efficacy for promoting wound healing.
[Stem Cell Research & Therapy] |
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Improved Outcomes of Single-Unit Cord Blood Transplantation for Acute Myeloid Leukemia by Killer Immunoglobulin-Like Receptor 2DL1-Ligand Mismatch | To investigate their role in acute myeloid leukemia, mismatch of KIR2DL1, KIR3DL1, and KIR3DL2-ligand were retrospectively assessed in patients undergoing cord blood transplantation with GVHD prophylaxis comprising a calcineurin inhibitor plus methotrexate or mycophenolate mofetil.
[Bone Marrow Transplantation] |
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Trafficking and Persistence of Alloantigen-Specific Chimeric Antigen Receptor Regulatory T Cells in Cynomolgus Macaque | The authors describe a culture system that massively expands CAR Tregs specific for the Bw6 alloantigen. In vitro, these Tregs suppressed in an antigen-specific manner without pro-inflammatory cytokine secretion or cytotoxicity.
[Cell Reports Medicine] |
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CAR T-Cell Therapy in Highly-Aggressive B-Cell Lymphoma: Emerging Biological and Clinical Insights | As more experience with CAR T-cell approaches is examined, it is interesting to consider how both tumor-cell specific and microenvironment factors that define these highly aggressive subsets influence susceptibility to this approach.
[Blood] |
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Stem Cell Transplantation for Induction of Remission in Medically Refractory Crohn’s Disease | Stem cell therapy (SCT) is an innovative treatment that has been recently used in Crohn’s disease (CD). The exact role of SCT in CD is still unclear.
[Cochrane Database of Systematic Reviews] |
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University of Nottingham Partnership Part of £20M Investment in New Blood and Transplant Units | The University of Nottingham is one of five research units across blood, organ, plasma, and stem cells launched by NHS Blood and Transplant.
[The University of Nottingham] |
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BC Researchers Launching Clinical Trial for First Genetically Engineered Stem Cell-Based Therapy for Type 1 Diabetes | Researchers from the UBC Faculty of Medicine and Vancouver Coastal Health have received $1 million from Canada’s Stem Cell Network to conduct research and a clinical trial for one of the world’s first genetically engineered cell replacement therapies for type 1 diabetes.
[The University of British Columbia] |
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| 13 – 14 June 2022
London, England, United Kingdom |
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| | Bristol Myers Squibb – Devens, Massachusetts, United States |
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| | STEMCELL Technologies, Inc. – Vancouver, British Columbia, Canada |
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| Johns Hopkins University School of Medicine – St. Petersburg, Florida, United States |
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| European Molecular Biology Laboratory – Barcelona, Spain |
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| | Helmholtz Munich – München, Germany |
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