 | | Vol. 23.18 – 30 May, 2022 |
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| The authors showed that mobilizers created an opportunity for seamless engraftment of exogenous cells, which effectively outcompeted those mobilized, to repopulate the depleted bone marrow.
[Cell] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists showed the detection of cell surface death receptor target on CD146-enriched circulating tumor cells captured from the blood of mice bearing glioblastoma (GBM) and patients diagnosed with GBM.
[Nature Communications] |
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| Residual cells obtained after washing 61 anti-CD19 CAR-T product bags were analyzed to identify tisagenlecleucel/Tisa-cel and axicabtagene ciloleucel/Axi-cel phenotypic features associated with post-infusion CAR-T cell in vivo expansion and with response and survival.
[Clinical Cancer Research] |
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| In this multicenter retrospective analysis, researchers characterized early infection events and clinical outcomes in 248 patients receiving standard-of-care CD19 CAR-T for relapsed/refractory large B cell lymphoma.
[Journal For Immunotherapy of Cancer] |
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| The oral delivery of stem-cell-loaded hydrogel microcapsules enhanced mesenchymal stem cell survival and retention in the hostile stomach environment due to the intermediate oil layer and low value of the overall stiffness.
[Journal of Controlled Release] |
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| Investigators described survival outcomes according to autologous stem cell transplantation PET status according to Lugano criteria in 172 relapsed or refractory (R/R) follicular lymphoma patients within a national, multicentre, retrospective BSBMTCT registry study.
[Haematologica] |
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| Scientists evaluated the factors associated with durable systemic therapy (ST) discontinuation, defined as cessation of all ST for ≥12 months, using data from two prospectively followed cohorts from the chronic graft-versus-host disease Consortium.
[Haematologica] |
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| The authors determined the probable toxicity effects of local and systemic injections of cryopreserved human bone marrow-derived clonal mesenchymal stem cell during subacute and subchronic periods of time.
[Stem Cell Research & Therapy] |
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| Scientists conducted an open-label, single-arm exploratory Phase I clinical study in which 12 periodontitis patients were transplanted with autologous adipose tissue-derived multi-lineage progenitor cells isolated from subcutaneous adipose tissue.
[Scientific Reports] |
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| Researchers treated five patients suffering from relapsed acute lymphoblastic leukemia (ALL) with daratumumab. Four patients had T ALL, three of whom achieved complete remission after treatment and underwent stem cell transplant.
[Pediatric Blood & Cancer] |
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| The authors discuss the application and limitation of the recently-used advanced approaches for regeneration of cornea. [Journal of Tissue Engineering and Regenerative Medicine]
[nan] |
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| The contract research organization Inotiv is neglecting animals at a research facility in Indiana that conducts toxicity testing of experimental drugs, the Humane Society of the United States alleged.
[ScienceInsider] |
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| Neurona Therapeutics announced that it has been awarded a $7,999,999 grant by the California Institute for Regenerative Medicine to support a dose-escalation Phase I/II clinical trial of NRTX-1001, an inhibitory cell therapy that is being evaluated for safety and efficacy in people with drug-resistant mesial temporal lobe epilepsy.
[Neurona Therapeutics] |
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| August 7 – 12, 2022
Castelldefels, Spain |
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| | Columbia University – New York, New York, United States |
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| | Utrecht University – Utrecht, Netherlands |
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| | Bristol Myers Squibb – Devens, Massachusetts, United States |
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| Johns Hopkins University School of Medicine – St. Petersburg, Florida, United States |
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