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| The authors generated a progressive series of genome-edited human models of melanoma, in which they started from healthy human melanocytes and introduced mutations in up to five genes spanning six pathways commonly dysregulated in melanoma.
[Science] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
| | DERMAL STEM CELLS & TISSUE REGENERATION |
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| Researchers used a system of controlled tissue expansion in mice to uncover cellular and molecular determinants of skin growth.
[Science Advances] |
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| The authors found that PINK1-PRKN-mediated mitophagy was impaired in neomycin-treated hair cells. Additionally, they demonstrated that neomycin disrupted mitophagy through transcriptional inhibition of Pink1 expression, the key initiator of mitophagy.
[Autophagy] |
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| Scientists found that cutaneous PDGFRα+ fibroblast-expressing lncRNA-H19 accelerated the wound-healing process via promoting dermal fibroblast proliferation and macrophage infiltration in injured skin.
[Diabetes] |
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| Decoy receptor 3 (DcR3) is a soluble receptor for Fas ligand, LIGHT and TL1A, but it also exerts effector functions. The authors found that the constitutive expression of the DcR3 gene and protein was progressively suppressed during terminal differentiation of keratinocytes.
[Experimental & Molecular Medicine] |
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| Researchers obtained adipose-derived mesenchymal stem cell exosomes (ADMSC-Exos) and found that ADMSC-Exos significantly promoted the migration and proliferation of fibroblasts in a dose-dependent manner in vitro.
[Stem Cell Reviews and Reports] |
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| Investigators generated human induced pluripotent stem cell (hiPSC)-derived keratinocytes from patients carrying KRT5 dominant mutations and compared them to non-affected hiPSC-derived keratinocytes as well as their primary counterparts.
[Journal of Investigative Dermatology] |
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| Researchers used Slc45a2-deficient melanocyte and mouse models to elucidate the roles of Slc45a2 in melanogenesis and melanoma metastasis.
[Journal of Investigative Dermatology] |
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| Scientists investigated the photophysical properties of Chlorin e6-C-15-ethyl ester (LS-HB), evaluated the antitumor effect on melanoma in vitro and in vivo, and explored its possible mechanisms.
[Molecular Pharmaceutics] |
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| Investigators focus on the early phases of melanomagenesis by discussing how the originating pigment cell of the melanocyte lineage can be influenced to embark on a wide range of tumor fates with distinctive microanatomical pathways.
[Frontiers in Oncology] |
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| The authors cover the different origins of fish collagen reported in the different papers from the beginning of 2015 through the middle of 2021.
[Cell and Tissue Research] |
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| Investigators summarize the existing therapeutic mechanisms of Chinese herbal medicine in the treatment of psoriasis and provide a reference to develop future related studies in this field.
[Journal of Ethnopharmacology] |
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| Mindera Health™ has initiated a pilot program in California and Texas with a national health insurance company to assess the company’s Mind.Px™ test.
[Mindera Health™] |
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| September 19 – 20, 2022
Vejle, Denmark |
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| | Fred Hutchinson Cancer Center – Seattle, Washington, United States |
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| | University of Texas MD Anderson Cancer Center – Houston, Texas, United States |
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| | University of Texas MD Anderson Cancer Center – Houston, Texas, United States |
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| | City of Hope – Duarte, California, United States |
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| | Helmholtz Munich – München, Germany |
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