 | | Vol. 8.30 – 3 October, 2022 |
| |
|
|
| Mechanistically, local glucose depletion and hydrogen generation jointly attenuated the apoptosis of skin cells and promoted their proliferation and migration by inhibiting the synthesis of advanced glycation end products and the expression of their receptors, respectively.
[Nature Communications] |
|  |
|
|
| PUBLICATIONSRanked by the impact factor of the journal |
| |
|
|
| Researchers explored whether keratinocytes contributed to gasdermin E (GSDME) deficiency-caused aggravation of ultraviolet B (UVB)-induced skin inflammation in GSDME knockdown keratinocytes cultured in vitro and keratinocyte-specific GSDME conditional knockout mice.
[Cell Death & Disease] |
|
|
|
| In mice with imiquimod-induced psoriasis-like skin lesions, topical application of 2 mM malabaricone C significantly ameliorated hyperplasia and inflammatory cell infiltration, and suppressed the expression of the psoriasis-associated genes S100a9, Krt1, Il17a, and Il22.
[Free Radical Biology and Medicine] |
|
|
|
| Both in vitro and in vivo experiments confirmed that SIRT1 played important roles in adiponectin inhibiting the fibrotic phenotype transformation and proliferation of scar fibroblasts and improving skin fibrosis.
[iScience] |
|
|
|
| Scientists developed a melanoma skin equivalent based on an open-source epidermal model. Melanoma cell lines with different driver mutations were incorporated into these models forming distinguishable tumor aggregates within a stratified epidermis.
[Scientific Reports] |
|
|
|
| Exosomes secreted by highly metastatic melanoma cancer stem cells promoted the invasiveness of the low metastatic melanoma cells and accelerated metastatic progression. miR-1268a was up-regulated in cells and exosomes of highly metastatic melanoma cancer stem cells.
[Biological Research] |
|
|
|
|
| Wound-induced hair neogenesis provides a potential therapeutic window for manipulating cell fate by the introduction of factors during the wound healing process to enhance hair follicle formation.
[Cold Spring Harbor Perspectives in Biology] |
|
|
|
| The authors review precision dermatologic techniques/strategies as an important emerging approach for evaluation and management of skin disorders and cutaneous neoplasms, and relay how they may serve as a paradigm for the application of precision medicine beyond dermatology.
[Dermatology and Therapy] |
|
|
|
|
| The UK National Institute for Health and Care Excellence (NICE) has recommended pembrolizumab, manufactured by MSD, to treat melanoma.
[Pharmaceutical Business Review (MSD)] |
|
|
|
|
| February 9 – 12, 2023
Cancun, Mexico |
|
|
|
|
|
| | AstraZeneca – Cambridge, England, United Kingdom |
|
|
|
| | Garvan Institute of Medical Research – Sydney, Australia |
|
|
|
| | Netherlands Cancer Institute (AVL) – Amsterdam, Netherlands |
|
|
|
| | The National Psoriasis Foundation – Alexandria, Virginia, United States |
|
|
|
| | Cedars-Sinai – Los Angeles, California, United States |
|
|
|
|
Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
