GSDME Deficiency Leads to the Aggravation of UVB-Induced Skin Inflammation through Enhancing Recruitment and Activation of Neutrophils

Researchers explored whether keratinocytes contributed to Gasdermin E (GSDME) deficiency-caused aggravation of UVB-induced skin inflammation in GSDME knockdown keratinocytes cultured in vitro and keratinocyte-specific GSDME conditional knockout mice.