 | | Vol. 17.19 – 18 May, 2022 |
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Induction of Human Trophoblast Stem-Like Cells from Primed Pluripotent Stem Cells | Researchers established a simple procedure with a short-term treatment of bone morphogenetic protein 4 in trophoblast stem cell culture medium to convert human primed PSCs to trophoblast stem-like cells.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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Prenatal Glucocorticoid Exposure Selectively Impairs Neuroligin 1-Dependent Neurogenesis by Suppressing Astrocytic FGF2–Neuronal FGFR1 Axis | Scientists used human iPSC-derived neural stem cell to investigate how neurogenesis deficits occur.
[Cellular and Molecular Life Sciences] |
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A Real-Time Pluripotency Reporter for the Long-Term and Real-Time Monitoring of Pluripotency Changes in Induced Pluripotent Stem Cells | Mouse iPSCs were successfully generated from mouse embryonic fibroblasts harboring Oct4-EGFP transgene by introducing four factors, Oct4, Sox2, c-Myc and Klf4, under murine ESC culture conditions.
[Aging-Us] |
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Generation of an Induced Pluripotent Stem Cell Line from a Long QT Syndrome Patient Carrying KCNH2/1956C > a Mutation | A generated iPSC line showed typical ESC-like morphology, exhibited normal karyotype, expressed pluripotency markers, and was capable to differentiate into three germ layers.
[Stem Cell Research] |
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Generation of a Human Induced Pluripotent Stem Cell Line (JSPHi002-a) from a Patient with Long-QT Syndrome Type 1 Caused by KCNQ1 c.773A > T Mutation | Investigators generated an iPSCs line from the peripheral blood mononuclear cells collected from a patient with long QT syndrome type 1 via a non-integrating system.
[Stem Cell Research] |
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Therapeutic Development for Canavan Disease Using Patient iPSCs Introduced with the Wild Type ASPA Gene | Scientists differentiated the wild type aspartoacylase (ASPA)-expressing patient iPSCs into NPCs and showed that the resultant ASPA-Canavan disease NPCs exhibited potent ASPA enzymatic activity.
[iScience] |
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BRG1 Is a Biomarker of Hypertrophic Cardiomyopathy in Human Heart Specimens | Inhibition of BRG1 in human iPSC-derived cardiomyocytes significantly decreased MYH7 and increased MYH6, suggesting a regulatory role for BRG1 in the pathological imbalance of the two myosin heavy chain isoforms in human hypertrophic cardiomyopathy.
[Scientific Reports] |
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Anti-Nucleocapsid Antibodies Enhance the Production of IL-6 Induced by SARS-CoV-2 N Protein | To examine the cytokine production in COVID-19, researchers mimicked the disease in SARS-CoV-2-infected alveoli by adding the lysate of SARS-CoV-2-infected cells to cultured macrophages or iPSC-derived myeloid cells.
[Scientific Reports] |
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Differential Single Cell Responses of Embryonic Stem Cells Versus Embryoid Bodies to Gravity Mechanostimulation | Investigators provided novel evidence that ESC maintenance and embryoid body development could be regulated by gravity mechanostimulation and that stem cells committed to a differentiation program were more sensitive to gravity induced changes to their transcriptome.
[Stem Cells and Development] |
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The Effect of BMP4, FGF8 and WNT3a on Mouse iPS Cells Differentiating to Odontoblast-Like Cells | The authors investigated whether BMP4, FGF8, and/or WNT3a on neural crest-like cells derived from mouse induced pluripotent stem (iPS) cells would promote differentiation of odontoblasts-like cells.
[Medical Molecular Morphology] |
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Generation and Clinical Potential of Functional T Lymphocytes from Gene-Edited Pluripotent Stem Cells | Improved PSC-to-induced T platform coordinating gene editing technologies will provide various functional engineered unconventional or conventional T cells.
[Experimental Hematology & Oncology] |
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Molecular Insights into Cell Type-Specific Roles in Alzheimer’s Disease: Human Induced Pluripotent Stem Cell-Based Disease Modelling | The authors summarize the function of different cell types in the pathogenesis of Alzheimer’s disease (AD), such as neurons, microglia, and astrocytes, and recognize the potential of utilizing the rapidly growing iPSC technology in modeling AD.
[Neuroscience] |
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Sernova and Evotec Enter into an Exclusive Global Strategic Partnership for iPSC-Based Beta Cell Replacement Therapy to Develop and Commercialize a ‘Functional Cure’ for Diabetes | Sernova Corp. and Evotec SE announced an exclusive global strategic partnership to develop a best-in-class cell therapy treatment for people living with insulin-dependent diabetes.
[Sernova Corp. (GlobeNewswire, Inc.)] |
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IN8bio Announces Data Emerging from its Recently Unveiled Gamma-Delta T Cell “Off-the-Shelf” Induced Pluripotent Stem Cell Platform | IN8bio, Inc. announced data emerging from the company’s recently unveiled iPSC-based gamma-delta T cell platform. iPSCs represent a significant step toward next generation approaches of cellular manufacturing for true allogeneic ‘off-the-shelf’ innate cell therapies, and further broaden the Company’s capabilities around the expansion and genetic engineering of gamma-delta T cells.
[IN8bio, Inc.] |
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| September 19 – 20, 2022
Vejle, Denmark |
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| | Wellcome Sanger Institute – Cambridge, United Kingdom |
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| | Beth Israel Deaconess Medical Center – Boston, Massachusetts, United States |
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| Institute of Cancer Research – London, England, United Kingdom |
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| | Francis Crick Institute – London, United Kingdom |
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| | Helmholtz Munich – München, Germany |
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Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
