 | | Vol. 17.38 – 5 October, 2022 |
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| The authors demonstrated that promyelocytic leukemia protein (PML) was essential for oxidative stress-driven partner SUMO2/3 conjugation in mESCs or leukemia, a process often followed by their poly-ubiquitination and degradation.
[Nature Communications] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers performed comprehensive comparative epigenomic and transcription factor binding analyses among pigs, humans, and mice to identify pluripotency-associated super-enhancers.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| By profiling the relevant natural killer-activating ligands on iPSCs during in vitro differentiation into pancreatic β cells, scientists found that they expressed high levels of B7-H3 and CD155.
[Cell Reports] |
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| To explore the transition of hESCs toward differentiated cells, the activity and expression of the ubiquitous phosphatidylinositol 3-kinase, PI3Kα and PI3Kβ, were modulated in primed hESCs.
[Stem Cell Reports] |
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| Scientists demonstrated that a major contributor to cortical organoid quality was the way hPSCs were maintained prior to differentiation. Optimal results were achieved using particular fibroblast-feeder-supported hPSCs rather than feeder-independent cells.
[Stem Cell Reports] |
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| By knocking down REC8, RAD21, or the non-kleisin cohesin subunit SMC3 in mESCs, researchers showed that reduction in cohesin level impaired their self-renewal.
[Molecules and Cells] |
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| The authors utilized transcriptome sequencing data of iPSC and derived endothelial iPSC with or without CRISPR-Cas9 induced translocation to identify a panel of 15 candidate housekeeping genes.
[Scientific Reports] |
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| Co-immunoprecipitation studies highlighted novel protein interactors, many of which were also found in the cytosol and were implicated in mRNA processing and RNA and protein transport between the cytosol and the nucleus.
[Tissue and Cell] |
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| Investigators differentiated mESCs within osteogenic-inducing media containing either high or low levels of D-glucose and performed time course analyses to study the influence of high glucose on early and late bone cell differentiation.
[Birth Defects Research] |
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| The authors review models of human retinal disease, including animal models, and hPSC–derived models for their role in gene discovery and treatment of inherited retinal diseases .
[Retina-the Journal of Retinal and Vitreous Diseases] |
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| Kadimastem Ltd. has been granted its third patent approval for the company’s cell selection and enrichment technology and its use in the production of IsletRx, the company’s treatment and potential cure for diabetes.
[Kadimastem ltd.] |
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| Greenstone Biosciences, Inc., a commercial-stage computational biology company, announces that the company has received a DISC0 grant funding from the California Institute of Regenerative Medicine (CIRM).
[Greenstone Biosciences, Inc. (BioSpace.com)] |
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| February 5 – 8, 2023
Keystone, Colorado, United States |
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| | Memorial Sloan Kettering Cancer Center – New York, New York, United States |
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| | Yale University – New Haven, Connecticut, United States |
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| | NIH – Research Triangle Park, North Carolina, United States |
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| | InVitro Cell Research, LLC – Fort Lee, New Jersey, United States |
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| | Syracuse University – Syracuse, New York, United States |
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