 | | Vol. 17.39 – 12 October, 2022 |
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| Through separation-of-function experiments, researchers revealed that the collaboration between CKM–Mediator and canonical polycomb repressive complex 1 in creating long-range interactions did not function to prime genes for induction during differentiation.
[Nature Structural & Molecular Biology] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The transcriptome and epigenome were determined for iPSCs generated from human and chimpanzee individuals.
[Molecular Biology and Evolution] |
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| By assessing avian and human neural crest cells at distinct developmental stages, scientists characterized the epigenomic changes that occured during their specification, migration, and early differentiation.
[Developmental Cell] |
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| To accelerate the neuron production from hESCs, an acoustic stimulator producing surface acoustic waves was proposed and realized by clamping a flexible printed circuit board directly onto a piezoelectric substrate.
[Acta Biomaterialia] |
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| Based on FACS analysis and single-cell RNA sequencing, mESCs differentiated into multiple hematopoietic and stromal cell types that were indistinguishable from normal mouse bone marrow cells.
[eLife] |
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| The authors induced inactivating deletions of CEP83 in hiPSCs and applied a seven day in vitro protocol of intermediate mesoderm kidney progenitor differentiation, based on timed application of WNT and FGF agonists.
[eLife] |
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| Investigators demonstrated that yes-associated protein (YAP) functioned in an hESC-specific manner to maintain self-renewal and survival in hESCs. hESCs were highly sensitive to YAP downregulation to promote cell survival.
[Cellular and Molecular Life Sciences] |
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| Researchers generated an iPSC line of a severely affected Loeys-Dietz Syndrome patient carrying a pathogenic SMAD3 p.Arg287Gln variant. Peripheral blood mononuclear cells were reprogrammed using non-integrating Sendai viral vectors.
[Stem Cell Research] |
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| Using high-throughput sequencing, chromatin immunoprecipitation and luciferase reporter assays, scientists showed that Prdm14 directly bound to the promoter of Socs3 and repressed its transcription to increase the phosphorylation level of Stat3 protein.
[iScience] |
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| Investigators monoclonally isolated CD8+ T cells (TCs) specifically reactive with NY-ESO-1 from the melanoma patient’s monocytes after being stimulated with NY-ESO-1 peptide by manual procedure, and cultured NY-ESO-1-specific TCs until proliferated and formed colonies.
[Experimental Dermatology] |
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| The authors review recent literature on the mechanistic role of different types of autophagy in embryonic development, ESCs, and iPSCs, focusing on their remodeling functions on protein, metabolism, and epigenetics.
[Trends in Cell Biology] |
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| The Albanese Government is investing almost $7 million in Australia’s first stem cell research that will enable live stem cells to be 3D printed in order to treat damaged body parts.
[Commonwealth of Australia] |
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| February 9 – 12, 2023
Cancun, Mexico |
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| | UCLA Jules Stein Eye Institute – Los Angeles, California, United States |
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| | Memorial Sloan Kettering Cancer Center – New York City, New York, United States |
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| | Memorial Sloan Kettering Cancer Center – New York, New York, United States |
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| | Yale University – New Haven, Connecticut, United States |
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| | NIH – Research Triangle Park, North Carolina, United States |
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