Generation and Validation of an iPSC Line (BBANTWi008-a) from a Loeys-Dietz Syndrome Type 3 Patient

Researchers generated an iPSC line of a severely affected Loeys-Dietz Syndrome patient carrying a pathogenic SMAD3 p.Arg287Gln variant. Peripheral blood mononuclear cells were reprogrammed using non-integrating Sendai viral vectors.