Extracellular Matrix News Volume 13.16 | Apr 28 2022

April 28, 2022

2022-04-28 | ECM 13.16

Extracellular Matrix News by STEMCELL Technologies

Vol. 13.16 – 28 April, 2022

TOP STORY

Cell Division in Tissues Enables Macrophage Infiltration

Scientists found that dividing ectodermal cells disassembled ECM attachment formed by integrin-mediated focal adhesions next to mesodermal cells, allowing macrophages to move their nuclei ahead and invade between two immediately adjacent tissues.
[Science]

Abstract Press Release

Activate, expand, and differentiate your cells with cytokines, chemokines, and growth factors from STEMCELL Technologies.

PUBLICATIONSRanked by the impact factor of the journal

Programming Cellular Alignment in Engineered Cardiac Tissue via Bioprinting Anisotropic Organ Building Blocks

The authors reported the fabrication of aligned cardiac tissues via bioprinting anisotropic organ building blocks composed of human induced pluripotent stem cell-derived cardiomyocytes.
[Advanced Materials]

Abstract

Intervertebral Disc Degeneration Is Rescued by TGFβ/BMP Signaling Modulation in an Ex Vivo Filamin B Mouse Model

Utilizing a filamin B knockout mouse, researchers showed that the vertebral fusions in spondylocarpotarsal syndrome evolved from intervertebral disc degeneration and ossification of the annulus fibrosus, eventually leading to full trabecular bone formation.
[Bone Research]

Full Article

A High-Resolution Route Map Reveals Distinct Stages of Chondrocyte Dedifferentiation for Cartilage Regeneration

Investigators demonstrated a time-lapse atlas of chondrocyte dedifferentiation to provide molecular details and informative biomarkers associated with clinical chondrocyte evaluation.
[Bone Research]

Full Article

Mussel Inspired Trigger-Detachable Adhesive Hydrogel

Adhesion to many kinds of surfaces, including biological tissues, is important in many fields but has been proved to be extremely challenging. The authors developed a mussel inspired hydrogel to achieve both strong adhesion and trigger-detachment.
[Small]

Abstract

Highly Motile Cells Are Metabolically Responsive to Collagen Density

Researchers revealed a link between matrix mechanics, migratory phenotype, and bioenergetics and suggested that energetic costs were determined by the ECM and influenced cell motility.
[Proceedings of the National Academy of Sciences of the United States of America]

Abstract

Customized Bioreactor Enables the Production of 3D Diaphragmatic Constructs Influencing Matrix Remodeling and Fibroblast Overgrowth

The authors developed a tissue engineering approach based on decellularized diaphragmatic muscle and human cells for the in vitro generation of diaphragmatic-like tissues as a proof-of-concept of a new option for the surgical treatment of large diaphragm defects.
[npj Regenerative Medicine]

Full Article

Biomechanically and Biochemically Functional Scaffold for Recruitment of Endogenous Stem Cells to Promote Tendon Regeneration

Scientists combined the decellularized bovine tendon sheet (DBTS) with ECM from tendon-derived stem cells to fabricate a biomechanically and biochemically functional scaffold (tECM-DBTS), to provide a functional and stem cell ECM-based microenvironment for tendon regeneration.
[npj Regenerative Medicine]

Full Article

WISP-2 Modulates the Induction of Inflammatory Mediators and Cartilage Catabolism in Chondrocytes

The authors showed that Wnt-1 inducible signaling pathway protein 2 (WISP-2) may have had relevant roles in modulating the turnover of ECM in the cartilage and that its downregulation may have detrimentally altered the inflammatory environment in osteoarthritis cartilage.
[Laboratory Investigation]

Abstract

HDAC6 Regulates NF-κB Signaling to Control Chondrocyte IL-1-Induced MMP and Inflammatory Gene Expression

Histone deacetylase 6 (HDAC6) was required for both the interleukin (IL)-1 induction of matrix metalloproteinase (MMP) expression and pro-inflammatory interleukin expression in chondrocytes, implicating an effect on NF-κB signaling.
[Scientific Reports]

Full Article

Endothelial Inflammation and Neutrophil Transmigration Are Modulated by Extracellular Matrix Composition in an Inflammation-on-a-Chip Model

Researchers used the OrganoPlate to develop a humanized 3D in vitro inflammation-on-a-chip model to recapitulate neutrophil transmigration across the endothelium and subsequent migration through the ECM.
[Scientific Reports]

Full Article

In Vivo Engraftment into the Cornea Endothelium Using Extracellular Matrix Shrink-Wrapped Cells

The authors developed a technique to shrink-wrap micropatterned islands of corneal endothelial cells in a basement membrane-like layer of ECM that enabled the cells to maintain their cell-cell junctions and cytoskeletal structure while in suspension.
[Communications Materials]

Full Article

REVIEWS

Adhesion G Protein-Coupled Receptors: Structure, Signaling, Physiology and Pathophysiology

Scientists describe the recent advances that have led to a new understanding of adhesion G protein-coupled receptors function and also discuss new insights into the physiological actions of these receptors as well as their roles in human disease.
[Physiological Reviews]

Abstract

Incomplete Abscission and Cytoplasmic Bridges in the Evolution of Eukaryotic Multicellularity

The authors survey the distribution, function, and formation of cytoplasmic bridges across the eukaryotic tree of life. They find that cytoplasmic bridges are widespread, and were likely ancestrally present, in almost all lineages of eukaryotes with clonal multicellularity
[Current Biology]

Full Article

INDUSTRY AND POLICY NEWS

OncoC4 Announces Fast Track Designation Granted by the U.S. FDA for ONC-392 Monotherapy in PD(L)1-Resistant NSCLC

OncoC4, Inc. announced that the US FDA has granted Fast Track designation to ONC-392, the company’s next-gen anti-CTLA-4 monoclonal antibody as a single agent for the treatment of patients with metastatic non-small cell lung carcinoma (NSCLC) who have had disease progression on prior anti-PD-(L)1 therapy.
[OncoC4, Inc.]

Press Release

FEATURED EVENT

Extracellular Matrix News Volume 13.16 | Apr 28 2022

Cell Division in Tissues Enables Macrophage Infiltration

Programming Cellular Alignment in Engineered Cardiac Tissue via Bioprinting Anisotropic Organ Building Blocks

Intervertebral Disc Degeneration Is Rescued by TGFβ/BMP Signaling Modulation in an Ex Vivo Filamin B Mouse Model

A High-Resolution Route Map Reveals Distinct Stages of Chondrocyte Dedifferentiation for Cartilage Regeneration

Mussel Inspired Trigger-Detachable Adhesive Hydrogel

Highly Motile Cells Are Metabolically Responsive to Collagen Density

Customized Bioreactor Enables the Production of 3D Diaphragmatic Constructs Influencing Matrix Remodeling and Fibroblast Overgrowth

Biomechanically and Biochemically Functional Scaffold for Recruitment of Endogenous Stem Cells to Promote Tendon Regeneration

WISP-2 Modulates the Induction of Inflammatory Mediators and Cartilage Catabolism in Chondrocytes

HDAC6 Regulates NF-κB Signaling to Control Chondrocyte IL-1-Induced MMP and Inflammatory Gene Expression

Endothelial Inflammation and Neutrophil Transmigration Are Modulated by Extracellular Matrix Composition in an Inflammation-on-a-Chip Model

In Vivo Engraftment into the Cornea Endothelium Using Extracellular Matrix Shrink-Wrapped Cells

Adhesion G Protein-Coupled Receptors: Structure, Signaling, Physiology and Pathophysiology

Incomplete Abscission and Cytoplasmic Bridges in the Evolution of Eukaryotic Multicellularity

OncoC4 Announces Fast Track Designation Granted by the U.S. FDA for ONC-392 Monotherapy in PD(L)1-Resistant NSCLC

AACR: Advances in the Pathogenesis and Molecular Therapies of Liver Cancer

> See All Events

Tenure Track Faculty Position – Cell Signaling

Postdoctoral Position – 3D Bioprinting

Research Associate – Circadian and Cell Biology

Research Scientist – Pancreatic Adenocarcinoma Tumor Microenvironment

Postdoctoral Position – 3D Model Development

> See All Jobs