| Vol. 13.20 – 26 May, 2022 |
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| A photothermally controlled “oxygen bomb” PSPP-Au980-D was designed by encapsulating a perfluorocarbon core within a functionalized bilayer polymer shell. [Advanced Materials] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Using synthetic biology and tissue engineering, the authors developed and tested genetically engineered cartilage from murine induced pluripotent stem cells capable of preserving the circadian clock in the presence of inflammation. [Science Advances] |
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| Investigators reported an enzyme-activated assembled peptide FR17 that could serve as a “flame-retarding blanket” in the pre-metastatic niche specifically to extinguish the “fire” of tumor-supportive microenvironment adaption. [Nature Communications] |
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| Using osteosarcoma cells, scientists found that in addition to its known localizations on microtubules and the plasma membrane, MARK2 also associated with the actomyosin cytoskeleton and focal adhesions. [Current Biology] |
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| Researchers investigated the link between inflammation and cartilage mineralization by targeting Sirtuin 1 and lymphoid enhancer binding factor 1 (LEF1), both reported to have contrasting effects on cartilage. [Proceedings of the National Academy of Sciences of the United States of America] |
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| Knockdown of PILA inhibited tumor necrosis factor-induced NF-κB signaling, ECM catabolism, and apoptosis in chondrocytes, whereas ectopic expression of PILA promoted NF-κB signaling and matrix degradation. [Science Signaling] |
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| Scientists found that multiple myeloma cells promoted hyaluronan and proteoglycan link protein 1 expression and matrix metalloproteinase 2 activity in co-cultured bone marrow stromal cells. [Molecular Cancer Research] |
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| The authors comprehensively investigated different necroptosis patterns by the non-negative matrix factorization clustering analysis and explored the relationships among necroptosis patterns, infiltered immune cells, and tumor microenvironment scores. [Scientific Reports] |
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| Bioinformatic analysis showed ECM-receptor interaction pathways to be implicated in lymph node metastasis in early stage breast cancer patients. [Scientific Reports] |
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| Investigators discuss recent advances in the critical role of the extracellular polymeric substance matrix on biofilm growth and virulence on the dental implant surface and its effect on the etiopathogenesis and progression of implant-related infections. [Critical Reviews in Microbiology] |
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| Scientists describe the fundamental roles of C1q in various microenvironments and focus on the importance of the interactions of C1q and its receptors with the inhibitory receptor leukocyte-associated Ig-like receptor-1 (LAIR-1) in maintaining homeostasis. [Experimental & Molecular Medicine] |
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| Ocugen, Inc. announced that it is diversifying its innovative pipeline by introducing a Phase III, cell therapy platform technology called NeoCart®, autologous chondrocyte-derived neocartilage. [Ocugen, Inc.] |
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| June 26 – July 1, 2022 Castelldefels, Spain |
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| Albert Einstein College of Medicine – New York, New York, United States |
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| University of Plymouth – Plymouth, England, United Kingdom |
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| Jülich Research Centre – Jülich, Germany |
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| Cancer Research Center of Lyon – Lyon, France |
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