Extracellular Matrix News Volume 13.20 | May 26 2022

    0
    46







    2022-05-26 | ECM 13.20


    Extracellular Matrix News by STEMCELL Technologies
    Vol. 13.20 – 26 May, 2022
    TOP STORY

    NIR-II Photothermally Triggered “Oxygen Bomb” for Hypoxic Tumor Programmed Cascade Therapy

    A photothermally controlled “oxygen bomb” PSPP-Au980-D was designed by encapsulating a perfluorocarbon core within a functionalized bilayer polymer shell.
    [Advanced Materials]

    Abstract

    ON1080SCIC-YouTube-Channels-Announcements-728x90-2-1
    PUBLICATIONSRanked by the impact factor of the journal

    Synthetic Gene Circuits for Preventing Disruption of the Circadian Clock Due to Interleukin-1–Induced Inflammation

    Using synthetic biology and tissue engineering, the authors developed and tested genetically engineered cartilage from murine induced pluripotent stem cells capable of preserving the circadian clock in the presence of inflammation.
    [Science Advances]

    Full Article

    Peptide Nano-Blanket Impedes Fibroblasts Activation and Subsequent Formation of Pre-Metastatic Niche

    Investigators reported an enzyme-activated assembled peptide FR17 that could serve as a “flame-retarding blanket” in the pre-metastatic niche specifically to extinguish the “fire” of tumor-supportive microenvironment adaption.
    [Nature Communications]

    Full Article

    MARK2 Regulates Directed Cell Migration through Modulation of Myosin II Contractility and Focal Adhesion Organization

    Using osteosarcoma cells, scientists found that in addition to its known localizations on microtubules and the plasma membrane, MARK2 also associated with the actomyosin cytoskeleton and focal adhesions.
    [Current Biology]

    Abstract

    Lef1 Ablation Alleviates Cartilage Mineralization Following Posttraumatic Osteoarthritis Induction

    Researchers investigated the link between inflammation and cartilage mineralization by targeting Sirtuin 1 and lymphoid enhancer binding factor 1 (LEF1), both reported to have contrasting effects on cartilage.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Full Article

    The lncRNA PILA Promotes NF-κB Signaling in Osteoarthritis by Stimulating the Activity of the Protein Arginine Methyltransferase PRMT1

    Knockdown of PILA inhibited tumor necrosis factor-induced NF-κB signaling, ECM catabolism, and apoptosis in chondrocytes, whereas ectopic expression of PILA promoted NF-κB signaling and matrix degradation.
    [Science Signaling]

    Full Article

    A Hyaluronan and Proteoglycan Link Protein 1 Matrikine: Role of Matrix Metalloproteinase 2 in Multiple Myeloma NF-κB Activation and Drug Resistance

    Scientists found that multiple myeloma cells promoted hyaluronan and proteoglycan link protein 1 expression and matrix metalloproteinase 2 activity in co-cultured bone marrow stromal cells.
    [Molecular Cancer Research]

    Abstract

    Necroptosis-Associated Classification Combined with Tumor Microenvironment Characteristic Analysis of Cutaneous Melanoma

    The authors comprehensively investigated different necroptosis patterns by the non-negative matrix factorization clustering analysis and explored the relationships among necroptosis patterns, infiltered immune cells, and tumor microenvironment scores.
    [Scientific Reports]

    Full Article

    iTRAQ Proteomics of Sentinel Lymph Nodes for Identification of Extracellular Matrix Proteins to Flag Metastasis in Early Breast Cancer

    Bioinformatic analysis showed ECM-receptor interaction pathways to be implicated in lymph node metastasis in early stage breast cancer patients.
    [Scientific Reports]

    Full Article

    Tips to prepare for your next conference or networking event
    REVIEWS

    Polymicrobial Biofilms Related to Dental Implant Diseases: Unravelling the Critical Role of Extracellular Biofilm Matrix

    Investigators discuss recent advances in the critical role of the extracellular polymeric substance matrix on biofilm growth and virulence on the dental implant surface and its effect on the etiopathogenesis and progression of implant-related infections.
    [Critical Reviews in Microbiology]

    Abstract

    Understanding the Contextual Functions of C1q and LAIR-1 and Their Applications

    Scientists describe the fundamental roles of C1q in various microenvironments and focus on the importance of the interactions of C1q and its receptors with the inhibitory receptor leukocyte-associated Ig-like receptor-1 (LAIR-1) in maintaining homeostasis.
    [Experimental & Molecular Medicine]

    Full Article

    INDUSTRY AND POLICY NEWS

    Ocugen Announces New Cell Therapy Program Following FDA Regenerative Medicine Advanced Therapy (RMAT) Recognition

    Ocugen, Inc. announced that it is diversifying its innovative pipeline by introducing a Phase III, cell therapy platform technology called NeoCart®, autologous chondrocyte-derived neocartilage.
    [Ocugen, Inc.]

    Full Article

    FEATURED EVENT

    Endothelial Cell Phenotypes in Health and Disease

    June 26 – July 1, 2022
    Castelldefels, Spain

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Fellow – Microenvironment and Signaling

    Albert Einstein College of Medicine – New York, New York, United States

    PhD Studentship – Extracellular Matrix Adhesion and Cell Cycle Progression

    University of Plymouth – Plymouth, England, United Kingdom

    Principal Investigator – Interdisciplinary Research in Biology

    CNRS – Paris, France

    PhD Position – Mechanobiology

    Jülich Research Centre – Jülich, Germany

    Postdoctoral Fellow – Stromal Immune Interactions in Cancer

    Cancer Research Center of Lyon – Lyon, France

    > See All Jobs

    Submit an article, publication, job or event
    Brought to you by
    stemcell-logo-for newsletter-2
    Extracellular Matrix News Twitter