Extracellular Matrix News Volume 13.26 | Jul 7 2022

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    2022-07-07 | ECM 13.26


    Extracellular Matrix News by STEMCELL Technologies
    Vol. 13.26 – 7 July, 2022
    TOP STORY

    Tumoral Microenvironment Prevents De Novo Asparagine Biosynthesis in B Cell Lymphoma, Regardless of ASNS Expression

    Investigators demonstrated that supraphysiological or physiological concentrations of asparagine prevent de novo asparagine biosynthesis, regardless of asparagine synthetase (ASNS) expression levels.
    [Science Advances]

    Full Article

    Explore this validated protocol for high-efficiency gene editing of Human Pluripotent Stem Cells using the ArciTect™ CRISPR-Cas9 System.
    PUBLICATIONSRanked by the impact factor of the journal

    MARK2 Regulates Chemotherapeutic Responses Through Class IIa HDAC-YAP Axis in Pancreatic Cancer

    Through a Phos-tag-based kinome-wide screen, the authors identified microtubule affinity-regulating kinase proteins (MARK2) as a critical regulator for paclitaxel chemosensitivity in pancreatic ductal adenocarcinoma.
    [Oncogene]

    Full Article

    Data Driven and Biophysical Insights into the Regulation of Trafficking Vesicles by Extracellular Matrix Stiffness

    Pan-cancer analysis of cancer cells’ mechanical properties on substrates of varied stiffness and composition elucidated a heterogeneous cellular response to mechanical stimuli.
    [iScience]

    AbstractFull ArticleGraphical Abstract

    Patient-Specific Sarcoma Organoids for Personalized Translational Research: Unification of the Operating Room with Rare Cancer Research and Clinical Implications

    Surgically resected sarcomas were dissociated and incorporated into a hyaluronic acid and collagen-based ECM hydrogel and screened for chemotherapy efficacy.
    [Annals of Surgical Oncology]

    Abstract

    Human Placental Extract Activates a Wide Array of Gene Expressions Related to Skin Functions

    Investigators performed RNA-sequence analysis to investigate whether human placental extract altered ECM-related gene expression in normal human dermal fibroblast cells.
    [Scientific Reports]

    Full Article

    Targeting NAD Metabolism Regulates Extracellular Adenosine Levels to Improve the Cytotoxicity of CD8+ Effector T Cells in the Tumor Microenvironment of Gastric Cancer

    The authors targeted nicotinamide phosphoribosyltransferase, a rate-limiting enzyme in the NAD+ synthesis salvage pathway, to observe its effect in the immune microenvironment.
    [Journal of Cancer Research and Clinical Oncology]

    Full Article

    Establishment and Characterization of Novel Autologous Pair Cell Lines from Two Indian Non-Habitual Tongue Carcinoma Patients

    Two novel autologous pairs were immortalized spontaneously from non‑habitual, HPV‑positive patients, who presented with oral tongue squamous cell carcinoma.
    [Oncology Reports]

    Abstract

    A Study of the Comparative Effect of Cerium Oxide and Cerium Peroxide on Stimulation of Angiogenesis: Design and Synthesis of Pro-Angiogenic Chitosan/Collagen Hydrogels

    The authors reported the synthesis and neovascularization activity of cerium oxide and cerium peroxide nanoparticles when loaded into chitosan and collagen hydrogel.
    [Journal of Biomedical Materials Research Part B-Applied Biomaterials]

    Abstract

    Augmenting Osteochondral Autograft Transplantation and Bone Marrow Aspirate Concentrate with Particulate Cartilage Extracellular Matrix Is Associated With Improved Outcomes

    Scientists hypothesized that the placement of ECM-bone marrow aspirate concentrate around the osteochondral autograft transplant (OAT) graft would improve radiographic and patient-reported outcomes following OAT.
    [Foot & Ankle International]

    Abstract
    ON1104SM-Small-Molecules-Wallchart-728x90
    REVIEWS

    Tumor Growth towards Lower Extracellular Matrix Conductivity Regions under Darcy’s Law and Steady Morphology

    Investigators study a classic Darcy’s law model for tumor cell motion with inhomogeneous and isotropic conductivity.
    [Journal of Mathematical Biology]

    Abstract

    Immune Organoids: From Tumor Modeling to Precision Oncology

    The authors review the different methodologies for developing a more holistic patient-derived tumor organoid platform and for modeling the native immune tumor microenvironment.
    [Trends in Cancer]

    Abstract
    INDUSTRY AND POLICY NEWS

    Mogrify and Astellas Announce Collaboration to Conduct Research on In Vivo Regenerative Medicine Approaches to Address Sensorineural Hearing Loss

    Mogrify Limited and Astellas Pharma, Inc. announced that they have executed a collaborative research agreement on in vivo regenerative medicine approaches to address sensorineural hearing loss.
    [Mogrify Limited]

    Press Release
    FEATURED EVENT

    ASN Kidney Week

    November 1- 6, 2022
    Virtual

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    JOB OPPORTUNITIES

    Associate Professor – Thematic Research Programs

    The Chinese University of Hong Kong – Hong Kong, China

    Research Associate – Mechanochemistry

    University of Cambridge – Cambridge, England, United Kingdom

    Research Fellow – Biochemistry & Molecular Biology

    Max Planck Institute of Biochemistry – Munich, Germany

    Professor – Experimental Diabetes Research

    Uppsala University – Uppsala, Sweden

    Postdoctoral Fellow – Tumor Microenvironment

    University of California, San Francisco – San Francisco, California, United States

    > See All Jobs

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