Extracellular Matrix News Volume 13.37 | Sep 22 2022

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    2022-09-22 | ECM 13.37


    Extracellular Matrix News by STEMCELL Technologies
    Vol. 13.37 – 22 September, 2022
    TOP STORY

    Tissue Flow Regulates Planar Cell Polarity Independently of the Frizzled Core Pathway

    The authors showed that tissue flow was a mechanism governing core group-independent planar cell polarity on the Drosophila notum.
    [Cell Reports]

    Full ArticleGraphical Abstract
    Activate, expand, and differentiate your cells with cytokines, chemokines, and growth factors from STEMCELL Technologies.
    PUBLICATIONSRanked by the impact factor of the journal

    Clinical Significance of Matrix Metalloproteinase-9 in Fragile X Syndrome

    Scientists compared quantitative gel zymography and ELISA to determine which method better discriminated abnormal matrix metalloproteases-9 levels of individuals with Fragile X Syndrome from healthy controls and correlated with the clinical profile.
    [Scientific Reports]

    Full Article

    Noncanonical Wnt/Ror2 Signaling Regulates Cell–Matrix Adhesion to Prompt Directional Tumor Cell Invasion in Breast Cancer

    Investigators demonstrated that the noncanonical Wnt receptor, Ror2, regulates tumor cell–driven matrix remodeling and invasion in breast cancer.
    [Molecular Biology of the Cell]

    Abstract

    XMU-MP-1 Attenuates Osteoarthritis via Inhibiting Cartilage Degradation and Chondrocyte Apoptosis

    In chondrocytes, treatment with XMU-MP-1 elevated the matrix metalloproteinas and decreased the ECM induced by IL-1β.
    [Frontiers in Bioengineering and Biotechnology]

    Full Article

    Decellularized Bone Extracellular Matrix-Coated Electrospun PBAT Microfibrous Membranes with Cell Instructive Ability and Improved Bone Tissue Forming Capacity

    Researchers demonstrated that poly(butylene adipate-co-terephthalate) (PBAT) electrospun microfibrous membranes could be successfully modified with decellularized bone ECM to endow fibers with bioactive hydrogel and mimic natural micro-features of the native bone tissue.
    [Macromolecular Bioscience]

    Abstract

    High Strength and High Toughness Electrospun Multifibrillar Yarns with Highly Aligned Hierarchy Intended as Anisotropic Extracellular Matrix

    Scientists developed multifibrillar yarns with superior mechanical performance based on biocompatible polyacrylonitrile as surrogate ECM.
    [Macromolecular Bioscience]

    Abstract

    MiR-99a Alleviates Apoptosis and Extracellular Matrix Degradation in Experimentally Induced Spine Osteoarthritis by Targeting FZD8

    Overexpression of miR-99a significantly suppressed cell apoptosis and ECM degradation stimulated by IL-6 and TNF-α.
    [BMC Musculoskeletal Disorders]

    Full Article
    Stay current with COVID-19 research. Read Immunology of Infectious Disease News now.
    REVIEWS

    The Role of Myofibroblasts in Physiological and Pathological Tissue Repair

    Investigators focus on the central role of the cell, ECM, and tissue mechanics in regulating tissue repair by controlling myofibroblast action.
    [Cold Spring Harbor Perspectives in Biology]

    Abstract

    The Extracellular Matrix Alteration, Implication in Modulation of Drug Resistance Mechanism: Friends or Foes?

    Scientists highlight the most relevant ECM components presenting a comprehensive description of their physical, cellular, and molecular properties which can alter the therapy response of tumor cells.
    [Journal of Experimental & Clinical Cancer Research]

    Full Article

    Functions of Exogenous FGF Signals in Regulation of Fibroblast to Myofibroblast Differentiation and Extracellular Matrix Protein Expression

    The authors summarize the effects of fibroblast growth factors (FGFs) in fibroblast to myofibroblast differentiation and ECM protein expression and the underlying potential regulatory mechanisms to provide a basis for the clinical application of recombinant FGF protein drugs in the treatment of tissue damage.
    [Open Biology]

    Full Article
    INDUSTRY AND POLICY NEWS

    MIMEDX Announces Launch Of AXIOFILLâ„¢

    MiMedx Group, Inc. announced the launch of AXIOFILLâ„¢, an ECM Particulate product derived from human placental tissue. AXIOFILL is the first and only human placental-derived particulate product available for Surgical Recovery procedures.
    [MiMedx Group, Inc.]

    Press Release
    FEATURED EVENT

    4th Growth Factors in Regeneration and Regenerative Medicine Conference

    February 9 – 12, 2022
    Cancun, Mexico

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Position – Retinal Development

    University of Pittsburgh – Pittsburgh, Pennsylvania, United States

    PhD Student – Extracellular Matrix Architecture

    University Medical Center Freiburg – Freiburg, Germany

    PhD Student – Musculoskeletal Research Project

    University Hospital of Muenster – Münster, Germany

    Research Assistant – Cell-Scaffold Cytocompatibility and Osteogenic Potential

    National University of Ireland Galway – Galway, Ireland

    Research Specialist – Stem Cell Biology

    Karolinska Institutet – Flemingsberg, Sweden

    > See All Jobs

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