Extracellular Matrix News Volume 15.03 | Jan 25 2023

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    2024-01-25 | ECM 15.03


    Extracellular Matrix News by STEMCELL Technologies
    Vol. 15.03 – 25 January, 2024
    TOP STORY

    Highly Bioactive MXene-M2-Exosome Nanocomposites Promote Angiogenic Diabetic Wound Repair through Reconstructing High Glucose-Derived Immune Inhibition

    Researchers reported two-dimensional carbide-M2 macrophage exosome nanohybrids for promoting diabetic wound repair by overcoming the high-glucose-derived immune inhibition.
    [ACS Nano]

    AbstractGraphical Abstract
    An ISSCR 2022 Innovation Showcase Webinar: Robust Workflows for the Expansion of PSCs in 3D Suspension Culture, presented by Dr. Eric Jervis. Click to Watch Now.
    PUBLICATIONSRanked by the impact factor of the journal

    A Drug-Free Cardiovascular Stent Functionalized with Tailored Collagen Supports In-Situ Healing of Vascular Tissues

    Scientists showed that a drug-free coating formulation functionalized with tailored recombinant humanized type III collagen exerts one-produces-multi effects in response to injured tissue following stent implantation.
    [Nature Communications]

    Full Article

    Hierarchically Assembled Nanofiber Scaffold Guides Long Bone Regeneration by Promoting Osteogenic/Chondrogenic Differentiation of Endogenous Mesenchymal Stem Cells

    A 3D vertically aligned nanofiber scaffold (VAS) was developed with long channels and large pore size. The pore of VAS toward the bone marrow cavity after transplantation enabled the scaffolds to recruit bone marrow MSCs from the bone marrow cavity to the defect area.
    [Small]

    Abstract

    Mechanical Stiffness Promotes Skin Fibrosis via Piezo1-Wnt2/Wnt11-CCL24 Positive Feedback Loop

    Investigators reported a positive feedback loop mediated by the mechanosensitive ion channel Piezo1 and aberrant tissue mechanics in driving skin fibrosis.
    [Cell Death & Disease]

    Full Article

    Non-Alcoholic Fatty Liver Disease Promotes Breast Cancer Progression through Upregulated Hepatic Fibroblast Growth Factor 21

    Scientists investigated the impact of non-alcoholic fatty liver disease on breast cancer tumor growth and cell viability through the potential mediator, hepatic fibroblast growth factor 21.
    [Cell Death & Disease]

    Full Article

    Tumor-Derived Small Extracellular Vesicles Facilitate Omental Metastasis of Ovarian Cancer by Triggering Activation of Mesenchymal Stem Cells

    The impact of extracellular vesicles and miR-320a-activated adipose-derived mesenchymal stem cells on tumor growth and metastasis was assessed in subcutaneous and orthotopic ovarian cancer xenograft mouse models.
    [Cell Communication And Signaling]

    Full ArticleGraphical Abstract

    Arrestin Beta-2 Deficiency Exacerbates Periodontal Inflammation by Mediating Activating Transcription Factor 6 Activation and Abnormal Remodeling of the Extracellular Matrix

    The authors investigated the specific role of arrestin beta-2 (ARRB2) in the progression of periodontitis and the underlying mechanisms.
    [Journal Of Clinical Periodontology]

    Abstract

    Proteoglycan Inhibition of Canonical BMP-Dependent Cartilage Maturation Delays Endochondral Ossification

    BMP signaling was evaluated in chondrocytes of wild-type and PG mutant zebrafish and inhibited with temporal control using the drug DMH1 or an inducible dominant-negative BMP receptor transgene.
    [Development]

    Full Article

    Myofibroblastic Cancer-Associated Fibroblast Subtype Heterogeneity in Pancreatic Cancer

    Researchers evaluated the gene and protein expression differences in two myofibroblastic cancer-associated fibroblast (CAF) lines using single-cell and bulk RNA-sequencing. They utilized proliferation and migration assays to determine the effect of different CAF lines on a tumor cell line.
    [Journal Of Surgical Oncology]

    Abstract
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    REVIEWS

    The Roles and Regulatory Mechanisms of TGF-β and BMP Signaling in Bone and Cartilage Development, Homeostasis and Disease

    Scientists weave the background information with the latest advances in the signaling facilitated by transforming growth factor-βs (TGF-βs) and bone morphometric proteins (BMPs), and the advanced understanding of their diverse physiological functions and regulations.
    [Cell Research]

    Full Article

    Modelling and Targeting Mechanical Forces in Organ Fibrosis

    The authors highlight the mechanotransduction mechanisms by which various sources of physical force drive fibrotic disease processes, with an emphasis on central pathways that may be therapeutically targeted to prevent and reverse fibrosis.
    [Nature Reviews Bioengineering]

    Abstract
    INDUSTRY AND POLICY NEWS

    Strand Therapeutics Receives IND Clearance for Programmable mRNA Therapy STX-001 to Treat Solid Tumors

    Strand Therapeutics announced the US FDA has cleared its Investigational New Drug (IND) application to initiate a Phase I, first-in-human trial of STX-001. This multi-mechanistic synthetic self-replicating mRNA technology expresses an IL-12 cytokine directly into the tumor microenvironment.
    [Strand Therapeutics (BusinessWire)]

    Press Release
    FEATURED EVENT

    Microbiome Interactions in Health and Disease

    February 14 – 16, 2024
    Hinxton, England, United Kingdom

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    JOB OPPORTUNITIES

    Fellowship – Collagen Implants

    Center for Drug Evaluation and Research – Silver Spring, Maryland, United States

    Laboratory Technician – Radiation Oncology

    MD Anderson Cancer Center – Houston, Texas, United States

    PhD Student – Systemic Sclerosis

    University Hospital of Muenster – Münster, Germany

    Postdoctoral Position – Flatworm Bioadhesion

    University of Innsbruck – Innsbruck, Austria

    Postdoctoral Position – Tumor Microenvironment

    University of Lund – Lund, Sweden

    > See All Jobs

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