Extracellular Matrix News Volume 17.21 | Nov 5 2026

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    2026-11-05 | ECM 17.21


    Extracellular Matrix News by STEMCELL Technologies
    Vol. 17.21 – 05 November, 2026
    TOP STORY

    Programmable Microgel Degradation in Dynamic Granular Hydrogels Guides Extracellular Matrix Assembly during Tissue Repair

    Scientists designed dynamic granular hydrogels that are modularly assembled using microgels with pre-programmed and precise degradation rates ranging from a few days to several weeks.
    [Advanced Materials]

    Full Article
    Request your free EasySepâ„¢ sample and get a pair of highly coveted science socks.
    PUBLICATIONSListed by the impact factor of the journal

    Nicotinamide N-Methyltransferase Drives Fibroblast Activation and Skin Fibrosis in Systemic Sclerosis

    Researchers investigated the role of nicotinamide N-methyltransferase in dermal fibroblast activation and fibrosis in systemic sclerosis.
    [Annals of the Rheumatic Diseases]

    Full Article

    An Infusible Decellularized Extracellular Matrix Material Binds to Vasculature in Infarcted Myocardium and Induces Pro-Reparative Gene Expression Following Acute Myocardial Infarction through Inherent Avidity and Bioactive Signaling

    Investigators applied size-based fractionation to separate infusible decellularized ECM into its main components, enabling them to study how each component behaves in the context of inflammation and acute myocardial infarction.
    [Advanced Science]

    Full Article

    Stromal APOL4 Defines a Cancer-Associated Fibroblast State That Organizes a Chemosensitive Niche in Ovarian Cancer

    Combining patient-derived ex vivo carboplatin screening with bulk and single-cell transcriptomics, functional perturbation in cancer-associated fibroblasts, and high-resolution spatial transcriptomics, scientists identified stromal apolipoprotein L4 (APOL4) as a biomarker of platinum sensitivity.
    [Experimental & Molecular Medicine]

    Full Article

    Engineering the Synovial Lining-Sublining Architecture in a Human 3D Model to Study Macrophage-Fibroblast Interactions in Arthritis

    The authors developed a xeno-free, spatially organized 3D synovial membrane model that reconstructs the structural relationship between the macrophage lining and fibroblast-rich sublining compartment.
    [Biofabrication]

    Abstract

    Boosting Functional Dental Pulp Regeneration by a Biomimetic Self-Assembling Hydrogel through Remodeling the Stem Cell Niche

    Investigators developed an RQK-based strategy for functional dental pulp regeneration by integrating ECM-like architecture with instructive bioactive cues in a self-assembling hydrogel system.
    [Acta Biomaterialia]

    Abstract | Graphical Abstract

    Microtubule Stability Modulates Schlemm’s Canal Cell Mechanobiology and Outflow Facility in Glaucoma

    Researchers identified microtubules as a key component of the mechanotransduction machinery linking the mechanical microenvironment to Schlemm’s canal cell biomechanics and conventional outflow.
    [npj Biological Physics and Mechanics]

    Full Article
    Explore this validated protocol for high-efficiency gene editing of Human Pluripotent Stem Cells using the ArciTectâ„¢ CRISPR-Cas9 System.
    REVIEWS

    Cancer-Associated Fibroblasts: Origins, Functional Heterogeneity, and Therapeutic Potential

    The authors dissect the multifaceted roles of cancer-associated fibroblasts, from their promotion of cancer cell proliferation, invasion, and angiogenesis through secreted factors and extensive ECM remodeling, to their profound influence on the immune landscape.
    [Signal Transduction and Targeted Therapy]

    Full Article
    INDUSTRY AND POLICY NEWS

    FibroBiologics Announces Grant of European Patent for Fibroblast Delivery of Tumor Inhibitory Agents

    FibroBiologics, Inc. announced that the European Patent Office has granted European Patent No. EP 4454709, titled “Fibroblast Delivery of Tumor Inhibitory Agents. The patent covers methods of preparing fibroblasts as anti-cancer delivery compositions.
    [FibroBiologics, Inc.]

    Press Release

    Applied Biologics Announces Full Enrollment of BIOxHEALâ„¢ Phase III Sentinel Safety Cohort

    Applied Biologics, LLC. announced the completion of enrollment into the sentinel safety cohort of its Phase III randomized controlled clinical trial evaluating BIOxHEALâ„¢ in patients with chronic, nonhealing diabetic foot ulcers.
    [Applied Biologics, LLC. (BioSpace)]

    Press Release

    StimLabs® Announces Commercial Launch of DermaForm™, a Uniquely Engineered Collagen Scaffold Particulate Device

    StimLabs announced the commercial launch of DermaForm, an FDA 510(k)-cleared porcine-derived particulate collagen scaffold that manages a range of acute and chronic wounds.
    [StimLabs]

    Press Release
    FEATURED EVENT

    Fibrosis Frontiers: From Basic Mechanisms to Precision Therapies

    March 1-4, 2027
    Keystone, Colorado, United States

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Associate – Metabolic Hormone and Weight Loss Biology

    Baylor College of Medicine – Houston, Texas, United States

    Postdoctoral Researcher – Alphavirus Infections

    University at Buffalo – Buffalo, New York, United States

    Tenured and Tenure-Track Research Faculty Positions – Department of Molecular and Human Genetics

    Baylor College of Medicine – Houston, Texas, United States

    Postdoctoral Fellow – Genome Engineering

    The Icahn School of Medicine at Mount Sinai – New York City, New York, United States

    Proteomics Specialist – Structural Proteomics

    Human Technopole – Milan, Italy

    > See All Jobs

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