Stromal APOL4 Defines a Cancer-Associated Fibroblast State That Organizes a Chemosensitive Niche in Ovarian Cancer

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Combining patient-derived ex vivo carboplatin screening with bulk and single-cell transcriptomics, functional perturbation in cancer-associated fibroblasts, and high-resolution spatial transcriptomics, scientists identified stromal apolipoprotein L4 (APOL4) as a biomarker of platinum sensitivity.
[Experimental & Molecular Medicine]
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