 | | Vol. 13.39 – 4 October, 2022 |
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| From three AML RNA-seq cohorts, scientists constructed the B cell lymphoma-2 (BCL2) family signatures by applying an innovative gene-set selection method reflecting biological knowledge followed by non-negative matrix factorization.
[Genome Medicine] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers deleted Bmi1 from adult hematopoietic cells and found that this slowly depleted HSCs. Rather than inducing senescence, Bmi1 deficiency increased HSC division.
[Genes & Development] |
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| The authors showed that the expression of spi2 was restricted to hemogenic endothelial cells and to hematopoietic stem and progenitor cells in zebrafish.
[Development] |
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| Scientists analyzed progenitor cell dynamics, including the division rate, velocity, viability, and probability of lineage commitment at the single-cell level over time.
[Scientific Reports] |
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| An in vitro experimental system was used to determine the effect of MK0974 on EVI1high AML cell lines. The expression of CRLR and RAMP1-3 in EVI1high and EVI1low AML lines was evaluated by RT–PCR.
[Anticancer Research] |
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| | To uncover mutations that were below the detection of standard next-generation sequencing (NGS), a combination of targeted duplex sequencing and NGS was applied on 20 infants and 7 children with KMT2A-r acute lymphoblastic leukemia, 5 longitudinal and 6 paired relapse samples.
[HemaSphere] |
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| Investigators analyzed a population-based series of germline exome data of 432 patients who had undergone hematopoietic stem cell transplantation.
[Bone Marrow Transplantation] |
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| Researchers analyzed 289 AML patients 60 years or older undergoing non-myeloablative conditioning-hematopoietic stem cell transplantation. Hematopoietic cell transplantation comorbidity index risk was low, intermediate, or high in 36%, 31%, and 33% of patients, respectively.
[Bone Marrow Transplantation] |
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| A total of 975 acute lymphoblastic leukemia patients were enrolled and classified into pre-HSCT measurable residual disease (MRD)-positive and MRD-negative subgroups. Cox proportional hazard regression models were built for time-to-event outcomes.
[International Journal of Laboratory Hematology] |
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| Investigators propose that the resulting immunologic endotype is secondary to a persistent maladaptive reprioritization of myelopoiesis and pathologic activation of myeloid cells.
[Journal of Leukocyte Biology] |
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| The Oncology Institute, Inc. announced the enrollment of two of its patients as the first and second patients dosed in the United States in a Phase III open-label, randomized study of Pirtobrutinib versus Ibrutinib in patients with chronic lymphocytic leukemia/small lymphocytic lymphoma .
[The Oncology Institute, Inc. (GlobeNewswire, Inc.)] |
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| Abcuro, Inc. announced initiation of a Phase I/II dose escalation trial to evaluate the safety, tolerability, and proof-of-concept of ABC008 in patients with T cell large granular lymphocytic leukemia who suffer from anemia and/or neutropenia.
[Abcuro, Inc.] |
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| February 5 – 8, 2023
Keystone, Colorado, United States |
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| | University of Miami – Miami, Florida, United States |
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| | Baylor College of Medicine – Houston, Texas, United States |
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| | State University of New York at Stony Brook – Stony Brook, New York, United States |
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| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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| | The Jackson Laboratory – Bar Harbor, Maine, United States |
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