The CGRP Receptor Antagonist MK0974 Induces EVI1^high AML Cell Apoptosis by Disrupting ERK Signaling

An in vitro experimental system was used to determine the effect of MK0974 on EVI1high AML cell lines. The expression of CRLR and RAMP1-3 in EVI1high and EVI1low AML lines was evaluated by RT–PCR.