|
| The authors evaluated the potential of allogeneic gene-edited CAR T cells targeting CD123 to eliminate leukemia stem cells.
[Nature Communications] |
|  |
|
|
| PUBLICATIONSRanked by the impact factor of the journal |
|
|
|
| Investigators reported that numbers of maturing myeloid, T cell, and erythroid populations were increased in the bone marrow of mice lacking parathyroid hormone receptor in osteoprogenitors.
[Journal of Bone and Mineral Research] |
|
|
|
| Scientists used multi-omics approaches together with functional assays to assess global DNA methylome dynamics during the endothelial cells-to-hematopoietic stem and progenitor cells (HSPCs) transition in zebrafish, and determined that DNA methyltransferase 1 was essential for HSPC generation via repression of Notch signaling.
[Development] |
|
|
|
| Researchers concluded that primitive hematopoietic stem cells altered their differentiation potential with cell cycle progression and found that cycling stem cells expressed differentiation epitopes and altered their differentiation potential with cell cycle passage..
[Stem Cell Reviews and Reports] |
|
|
|
| The authors analyzed quiescent and cycling HSCs in the bone marrow after transplantation and during development and aging.
[Stem Cell Reviews and Reports] |
|
|
|
| Scientists evaluated outcomes of patients who underwent an ex vivo CD34+ -selected allogenic-HSC transplantation using myeloablative conditioning.
[Bone Marrow Transplantation] |
|
|
|
| Investigators found that Sirt1 knockout improved the maintenance of quiescence of aging HSCs and their functionality as well as mouse survival in serial bone marrow transplantation recipients.
[Communications Biology] |
| |
|
|
| Researchers retrospectively evaluated 93 consecutive high-risk myelodysplastic syndrome (MDS) patients undergoing allogenic-HSC transplantation in our institution, comparing discrepancies in clinical characteristics and outcomes between cases using Dec-intensified BUCY2 and traditional BUCY2 regimen.
[Bone Marrow Transplantation] |
|
|
|
| The authors performed a registry study on therapy-related myeloid neoplasm, both therapy-related myelodysplastic syndrome and AML following treatment for breast cancer who underwent a first allogeneic hematopoietic cell transplant.
[Bone Marrow Transplantation] |
|
|
|
| Investigators evaluated the therapeutic efficacy of ex vivo gene therapy targeting HSCs using a lentiviral vector to increase enzyme activity, reduce substrate accumulation, and improve astrocytosis and motor function.
[Molecular Therapy-Methods & Clinical Development] |
|  |
|
|
|
| Scientists review the current understanding of the molecular, cellular, genetic, and environmental contributions to atherosclerosis, from both individual pathway and systems perspectives.
[Cell] |
|
|
|
| Recent discoveries have placed tRNAs as key regulators of gene expression during hematopoiesis, especially in HSC maintenance and immune development.
[Trends in Immunology] |
|
|
|
| The authors examine recent developments in the embryonic understanding of osteoclast origin, as well as interactions within the immune environment to regulate normal and pathological bone development, homeostasis and repair.
[Development] |
|
|
|
|
| Dr. Michael Chu, medical oncologist and an assistant professor at the University of Alberta (U of A), leads the clinical trial on using CAR T cell therapy to specifically treat lymphoma and leukemia.
[The Gateway] |
|
|
|
|
| May 22 – 25, 2022
Denver, Colorado, United States |
|
|
|
|
|
| | NHS Blood and Transplant – London, England, United Kingdom |
|
|
|
| University Children’s Hospital – Zurich, Germany |
|
|
|
| | University Children’s Hospital of Zurich – Zurich, Switzerland |
|
|
|
| | The University of British Columbia – Vancouver, British Columbia, Canada |
|
|
|
| | Fred Hutchinson Cancer Research Center – Seattle, Washington, United States |
|
|
|
|
Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
