DNA Methylation Safeguards the Generation of Hematopoietic Stem and Progenitor Cells by Repression of Notch Signaling

Scientists used multi-omics approaches together with functional assays to assess global DNA methylome dynamics during the endothelial cells-to-hematopoietic stem and progenitor cells transition in zebrafish, and determined that DNA methyltransferase 1 was essential for HSPC generation via repression of Notch signaling.