Hematopoiesis News Volume 13.25 | Jun 28 2022

June 28, 2022

2022-06-28 | HN 13.25

Hematopoiesis News by STEMCELL Technologies

Vol. 13.25 – 28 June, 2022

TOP STORY

CKS1 Inhibition Depletes Leukemic Stem Cells and Protects Healthy Hematopoietic Stem Cells in Acute Myeloid Leukemia

Researchers studied the role of cyclin-dependent kinase regulatory subunit 1 (CKS1)–dependent protein degradation in primary human acute myeloid leukemia and healthy hematopoiesis xenograft models in vivo.
[Science Translational Medicine]

Abstract

Dr. Daniel Dever, describes a CRISPR-Cas9-based protocol for gene editing hematopoietic stem cells in this on-demand webinar.

PUBLICATIONSRanked by the impact factor of the journal

Clonal Reconstruction from Co-Occurrence of Vector Integration Sites Accurately Quantifies Expanding Clones In Vivo

Tracing of integration sites (IS) leads to mis-quantification of the true clonal spectrum and limits safety considerations in gene therapies. Hence, scientists used correlations between repeated measurements of IS abundances to estimate their mutual similarity and identify clusters of co-occurring IS, for which they assume a clonal origin.
[Nature Communications]

Full Article

Impaired Immunosuppressive Role of Myeloid-Derived Suppressor Cells in Acquired Aplastic Anemia

Myeloid-derived suppressor cells (MDSCs) populations were evaluated in acquired aplastic anemia in which aberrant immune mechanisms contributed to bone marrow destruction.
[Haematologica]

Abstract

Decoding Lymphomyeloid Divergence and Immune Hyporesponsiveness in G-CSF-Primed Human Bone Marrow by Single-Cell RNA-Seq

Through unbiased bioinformatics analysis, the authors showed the alterations in the transcriptional landscape of hematopoietic cells in granulocyte colony-stimulating factor (G-CSF)-primed bone marrow, and revealed that G-CSF-induced myeloid-biased differentiation initiated from the stage of lymphoid-primed multipotent progenitors.
[Cell Discovery]

Full Article

Long-Term Hematopoietic Stem Cells as a Parasite Niche during Treatment Failure in Visceral Leishmaniasis

Double bioluminescent/fluorescent Leishmania infantum and L. donovani reporter lines enabled the identification of long-term hematopoietic stem cells as a niche in the bone marrow with remarkably high parasite burdens, a feature confirmed for human hematopoietic stem cells.
[Communications Biology]

Full Article

CLINICAL RESEARCH

Lentivector Cryptic Splicing Mediates Increase in CD34⁺ Clones Expressing Truncated HMGA2 in Human X-Linked Severe Combined Immunodeficiency

Researchers report vector insertion site (VIS) analysis in blood lineages from first eight treated patients with longer follow up found a > 60-fold increase in frequency of forward-orientated VIS within intron 3 of the High Mobility Group AT-hook 2 gene.
[Nature Communications]

Full Article

Acute Kidney Injury within 100 Days Post Allogeneic Hematopoietic Cell Transplantation Is Associated with Increased Risk of Post-Transplant Complications and Poor Transplant Outcomes

Scientists investigated the incidence of AKI and its impact on transplant outcomes among 408 patients transplanted at Princess Margaret Hospital Cancer Centre, Toronto, Canada.
[Bone Marrow Transplantation]

Abstract

Kinetics of Disappearance and Appearance of Isoagglutinins A and B after ABO-Incompatible Hematopoietic Stem Cell Transplantation

In a one-year follow-up, data of 136 ABO-incompatible hematopoietic stem cell allogeneic transplanted patients were studied, of which 60 had major, 61 minor and 15 bidirectional incompatibility.
[Bone Marrow Transplantation]

Full Article

Successful Outcomes of Second Hematopoietic Stem Cell Transplantation for Graft Failure in Pediatric Patients with Severe Aplastic Anemia

The authors analyzed 10 cases of second hematopoietic stem cell transplantation (HSCT) to treat severe aplastic anemia pediatric patients who suffered from graft failure and concluded that second haploidentical family donors HSCT is an effective treatment.
[Scientific Reports]

Full Article

Watch 'collaborating to accelerate COVID-19 research'

REVIEWS

Toward the Dissection of Hematopoietic Stem Cell Fates and Their Determinants

Recently, genetic in vivo approaches have been developed for lineage tracing of differentiating progeny emerging from hematopoietic stem cell (HSC) over time (output), and for high-resolution, endogenous barcoding to uncover the lineages that HSC contribute to (fate).
[Current Opinion in Genetics & Development]

Full Article

Game of Clones: Diverse Implications for Clonal Hematopoiesis in Lymphoma and Multiple Myeloma

Investigators review the basic biology and known health effects of clonal hematopoiesis (CH), and focus on the clinical relevance of CH in lymphoma and multiple myeloma.
[Blood Reviews]

Abstract

INDUSTRY AND POLICY NEWS

Veloxis Pharmaceuticals Announces Dosing of the First Patient by Partner Xenikos in the Global Phase III Study Evaluating T-Guard^® in Patients with Steroid-Refractory Acute Graft-versus-Host Disease (SR-aGVHD)

Veloxis Pharmaceuticals announced dosing of the first patient by its partner, Xenikos, in a Phase III clinical study designed to evaluate T-Guard^® versus ruxolitinib for the treatment of patients with Grade III or IV SR-aGVHD following allogeneic hematopoietic stem cell transplant.
[Veloxis Pharmaceuticals]

Press Release

Precision BioSciences Announces In Vivo Gene Editing Collaboration with Novartis to Develop Potentially Curative Treatment for Disorders Including Sickle Cell Disease

Precision BioSciences, Inc. announced it has entered into an exclusive worldwide in vivo gene editing research and development collaboration and license agreement with Novartis Pharma AG.
[Precision BioSciences, Inc.]

Press Release

FEATURED EVENT

Hematopoiesis News Volume 13.25 | Jun 28 2022

CKS1 Inhibition Depletes Leukemic Stem Cells and Protects Healthy Hematopoietic Stem Cells in Acute Myeloid Leukemia

Clonal Reconstruction from Co-Occurrence of Vector Integration Sites Accurately Quantifies Expanding Clones In Vivo

Impaired Immunosuppressive Role of Myeloid-Derived Suppressor Cells in Acquired Aplastic Anemia

Decoding Lymphomyeloid Divergence and Immune Hyporesponsiveness in G-CSF-Primed Human Bone Marrow by Single-Cell RNA-Seq

Long-Term Hematopoietic Stem Cells as a Parasite Niche during Treatment Failure in Visceral Leishmaniasis

Lentivector Cryptic Splicing Mediates Increase in CD34⁺ Clones Expressing Truncated HMGA2 in Human X-Linked Severe Combined Immunodeficiency

Acute Kidney Injury within 100 Days Post Allogeneic Hematopoietic Cell Transplantation Is Associated with Increased Risk of Post-Transplant Complications and Poor Transplant Outcomes

Kinetics of Disappearance and Appearance of Isoagglutinins A and B after ABO-Incompatible Hematopoietic Stem Cell Transplantation

Successful Outcomes of Second Hematopoietic Stem Cell Transplantation for Graft Failure in Pediatric Patients with Severe Aplastic Anemia

Toward the Dissection of Hematopoietic Stem Cell Fates and Their Determinants

Game of Clones: Diverse Implications for Clonal Hematopoiesis in Lymphoma and Multiple Myeloma

Veloxis Pharmaceuticals Announces Dosing of the First Patient by Partner Xenikos in the Global Phase III Study Evaluating T-Guard^® in Patients with Steroid-Refractory Acute Graft-versus-Host Disease (SR-aGVHD)

Precision BioSciences Announces In Vivo Gene Editing Collaboration with Novartis to Develop Potentially Curative Treatment for Disorders Including Sickle Cell Disease

Danish Stem Cell Society (DASCS) 2022

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Postdoctoral Fellow – Immunology, Epigenetics, and Cellular Metabolism

Post-Doctoral Fellow – Translational Immunology in Cell Therapies

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