Long-Term Hematopoietic Stem Cells as a Parasite Niche during Treatment Failure in Visceral Leishmaniasis

Double bioluminescent/fluorescent Leishmania infantum and L. donovani reporter lines enabled the identification of long-term hematopoietic stem cells as a niche in the bone marrow with remarkably high parasite burdens, a feature confirmed for human hematopoietic stem cells.