Hematopoiesis News Volume 13.29 | July 26 2022

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    2022-07-28 | HN 13.29


    Hematopoiesis News by STEMCELL Technologies
    Vol. 13.29 – 26 July, 2022
    TOP STORY

    Transcription Factors TCF-1 and GATA3 Are Key Factors for the Epigenetic Priming of Early Innate Lymphoid Progenitors Toward Distinct Cell Fates

    Investigators reported the identification of distinct accessible chromatin regions in all lymphoid progenitors, early innate lymphoid progenitors, and innate lymphoid cell precursors.
    [Immunity]

    Abstract

    ON1104SM-Small-Molecules-Wallchart-728x90
    PUBLICATIONSRanked by the impact factor of the journal

    Discovering the Drivers of Clonal Hematopoiesis

    Using the tumor sample in blood/tumor pairs as reference, scientists identified blood somatic mutations across more than 12,000 donors from two large cancer genomics cohorts.
    [Nature Communications]

    Full Article

    Lack of COL6/Collagen VI Causes Megakaryocyte Dysfunction by Impairing Autophagy and Inducing Apoptosis

    Researchers demonstrated by in vitro and in vivo approaches that megakaryocytes derived from col6a1−⁄− null mice displayed increased intracellular retention of COL6 polypeptides, endoplasmic reticulum stress, and apoptosis.
    [Autophagy]

    Abstract

    Hypercortisolemic Cushing’s Patients Possess a Distinct Class of Hematopoietic Progenitor Cells Leading to Erythrocytosis

    Scientists indicated that chronic exposure to excess glucocorticoids in vivo led to erythrocytosis by generating erythroid progenitor cells with a constitutively active glucocorticoid receptor.
    [Haematologica]

    Abstract

    Direct TLR2 Signaling through mTOR and TBK1 Induces C/EBPβ and IRF7-Dependent Macrophage Differentiation in Hematopoietic Stem and Progenitor Cells

    Investigators have used an in vitro model of murine hematopoietic stem and progenitor cells (HSPCs) to study myeloid differentiation in response to the TLR2 ligand Pam3CSK4 and showed that, besides indirect mechanisms, TLR2 stimulation of HSPCs promoted myelopoiesis directly by initiating a MyD88-dependent signaling.
    [Stem Cells]

    Abstract

    Csf1rb Regulates Definitive Hematopoiesis in Zebrafish

    Researchers showed a surprising role of Csf1rb, a zebrafish homolog of mammalian CSF1R, in preserving the hematopoietic stem and progenitor cell (HSPC) pool by maintaining the proliferation of HSPCs.
    [Development]

    Abstract

    Extracellular Adenosine (eAdo) – A2B Receptor Axis Inhibits in Nlrp3 Inflammasome-Dependent Manner Trafficking of Hematopoietic Stem/Progenitor Cells

    eAdo impaired hematopoietic stem/progenitor cells trafficking and this occurred in autocrine- and paracrine-dependent manner by direct stimulation of these cells or by affecting cells in the bone marrow microenvironment.
    [Stem Cell Reviews and Reports]

    Full ArticleGraphical Abstract

    PU.1-Dependent Enhancer Inhibition Separates Tet2-Deficient Hematopoiesis from Malignant Transformation

    Scientists showed that ten-eleven translocation-2 (Tet2) deficient mouse hematopoietic stem and progenitor cells underwent malignant transformation upon compromised gene regulation through heterozygous deletion of an upstream regulatory region of the PU.1 gene.
    [Blood Cancer Discovery]

    Abstract

    Autologous Stem Cell Transplantation Improves Cardiopulmonary Exercise Testing Outcomes in Systemic Sclerosis Patients

    Researchers assessed cardiopulmonary function outcomes of systemic sclerosis (SSc) patients after autologous hematopoietic stem cell transplantation (AHSCT). Twenty-seven SSc adult patients treated with AHSCT were included in this retrospective study.
    [Rheumatology]

    Abstract

    STEMCELL has implemented an Environmental Management System that is now ISO 14001-certified.
    REVIEWS

    Aging and Rejuvenation of Tissue Stem Cells and Their Niches

    The authors discuss cellular and molecular mechanisms underlying aging in the regenerative regions of different tissues as well as potential rejuvenation strategies.
    [Nature Reviews Molecular Cell Biology]

    Abstract

    Immune Senescence in Multiple Myeloma — a Role for Mitochondrial Dysfunction?

    Investigators outline our current understanding of normal immune aging, describe the mechanism of immunometabolic dysfunction in accelerating this process, and propose the role these processes are playing in the pathogenesis of multiple myeloma.
    [Leukemia]

    Abstract

    INDUSTRY AND POLICY NEWS

    Kite’s CAR T Cell Therapy Tecartus® Receives Positive CHMP Opinion in Relapsed or Refractory Acute Lymphoblastic Leukemia (r/r ALL)

    Kite announced that the European Medicines Agency Committee for Medicinal Products for Human Use (CHMP) has issued a positive opinion for Tecartus® for the treatment of adult patients 26 years of age and above with r/r ALL.
    [Gilead Sciences, Inc.]

    Press Release

    FEATURED EVENT

    EHA-SWG Scientific Meeting on Integrated Cell Tracking in Oncohematology

    November 10 – 12, 2022
    Bordeaux, France

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Researcher – Biofabrication of 3D Bone Metastasis Model

    Warsaw University of Technology – Warsaw, Poland

    Postdoctoral Fellows – Stem Cell Biology

    Institute for Research in Biomedicine – Barcelona, Spain

    Associate Professor – Thematic Research Programs

    The Chinese University of Hong Kong – Hong Kong, China

    Associate Professor – Oncology

    Fred Hutchinson Cancer Research Center – Seattle, Washington, United States

    Scientific Editor – Blood Cancer Discovery

    American Association for Cancer Research – Various, United States

    > See All Jobs

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