Lack of COL6/Collagen VI Causes Megakaryocyte Dysfunction by Impairing Autophagy and Inducing Apoptosis

Researchers demonstrated by in vitro and in vivo approaches that megakaryocytes derived from col6a1−⁄− null mice display increased intracellular retention of COL6 polypeptides, endoplasmic reticulum stress and apoptosis.