 | | Vol. 13.38 – 27 September, 2022 |
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| After infusion of lymph node (LN) cells mismatched at the major histocompatibility complex, RUX, administered as a food additive, attenuated bone marrow hypoplasia, ameliorated peripheral blood pancytopenia, and prevented mortality, when used either prophylactically or therapeutically.
[Blood] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators used a large-scale CRISPR interference viability screen to interrogate cell growth dependency to lncRNA genes in multiple myeloma, and identified a prominent role for the miR-17-92 cluster host gene.
[Blood] |
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| Scientists demonstrated that cell adhesion-related genes were predominantly enriched in DNMT3A-mutant AML cells and identified that graphdiyne oxide displayed an anti-leukemia effect specifically against these mutated cells.
[Nature Communications] |
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| Researchers showed that sleep interruption restructures the epigenome of hematopoietic stem and progenitor cells and increased their proliferation, thus reducing hematopoietic clonal diversity through accelerated genetic drift.
[Journal of Experimental Medicine] |
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| Investigators demonstrated that leukemia stem cells preferentially accumulated in the spleen and contribute to disease progression.
[Leukemia] |
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| Researchers reported that activated MYC signaling was an actionable molecular vulnerability in vitro and in a pre-clinical murine in vivo model of MYCdriven B cell lymphoma.
[Haematologica] |
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| It was found that ABAT gene interference increased the sensitivity of HL-60 and THP-1 cells to HMAs treatment, while ABAT overexpression decreased its sensitivity.
[Cell Death Discovery] |
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| The authors developed healthy donor-derived, CD7-targeting CAR-T cells with genetic modifications to resist fratricide, graft-veruss-host disease and allogeneic rejection, as well as to potentiate antitumor function.
[Cell Research] |
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| This multicenter study evaluated the characteristics, outcomes, and prognostic factors of allogeneic hematopoietic cell transplantation (HCT) in recipients with JMML who were diagnosed between 2000 and 2019 in Korea.
[Bone Marrow Transplantation] |
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| Bone marrow megakaryocytess are heterogeneous and can be clustered into three–four subpopulations: a subgroup that is adjacent to the hematopoietic stem cells, a subgroup expressing genes for platelet biogenesis, and a subgroup expressing immune-responsive genes.
[Journal of Biological Chemistry] |
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| Madeline Mayday, a 4th Experimental Pathology graduate student was awarded a 2022 National Institute of Diabetes and Digestive and Kidney Diseases Hematology Centers Program Type B Pilot and Feasibility grant for her project: “Investigation of RBM15 and the m6A Epitranscriptome in Megakaryopoiesis.”
[Yale School of Medicine] |
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| January 23 – 25, 2022
Breckenridge, Colorado, United States |
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| | Baylor College of Medicine – Houston, Texas, United States |
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| | State University of New York at Stony Brook – Stony Brook, New York, United States |
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| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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| | Beckman Research Institute – Monrovia, California, United States |
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| | The Jackson Laboratory – Bar Harbor, Maine, United States |
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