 | | Vol. 15.03 – 30 January, 2024 |
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| The authors introduced an improved single-cell lineage tracing system based on deep detection of naturally-occurring mitochondrial DNA mutations with simultaneous readout of transcriptional states and chromatin accessibility.
[Nature] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers explored the feasibility of immunotherapeutically targeting neoantigens, which arise from recurrent non-synonymous mutations in AML, and thus represent attractive targets since they are exclusively present on the tumor.
[Blood] |
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| Scientists found that while PI3Kγ was highly enriched in leukemia stem cells and critical for self-renewal, it was dispensable for normal hematopoietic stem cells.
[Blood] |
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| The authors showed that iron was increasingly taken up by HSCs during anemia and induced erythroid gene expression and regeneration in a Tet2-dependent manner.
[Nature Communications] |
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| Scientists investigated caloric restriction’s impact on several mouse models of acute myeloid leukemias, including acute promyelocytic leukemia, a subtype strongly affected by obesity.
[Nature Communications] |
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| Investigators found that the YEATS domain-containing histone acetylation reader ENL (eleven-nineteen leukemia) acted as a key regulator of super-enhancers, which are highly active distal CREs, across cancer types.
[Cancer Research] |
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| Researchers used inducible clonal DNA barcoding of endogenous adult HSCs to trace their contribution to major hematopoietic cell lineages in unmanipulated animals.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| The retrospective study enrolled 259 patients aged over 55 years who underwent their first allogenic hematopoietic stem cell transplantation between April 2015 and August 2022.
[Stem Cell Research & Therapy] |
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| Eight severe aplastic anemia patients with graft failure with a median age of 12.5 years were retrospectively reviewed.
[Scientific Reports] |
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| CD36 is a transmembrane glycoprotein, located on surface of numerous cell types. The authors aimed to explore regulatory role of CD36 in hematopoiesis beyond fatty acid uptake.
[Life Sciences] |
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| Nature talks to Sholto David about his process for flagging image manipulation and his tips for scientists under scrutiny.
[Nature News] |
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| March 18 – 19, 2024
London, England, United Kingdom |
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| | City of Hope – Duarte, California, United States |
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| | Human Technopole – Milan, Italy |
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| | University of Texas MD Anderson Cancer Center – Houston, Texas, United States |
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| | Karolinska Institutet – Huddinge, Sweden |
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| | Guangzhou Institutes of Biomedicine and Health – Guangzhou, China |
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