Targeting the Epigenetic Reader ENL Inhibits Super-Enhancer-Driven Oncogenic Transcription and Synergizes with BET Inhibition to Suppress Tumor Progression

Investigators found that the YEATS domain-containing histone acetylation reader ENL (eleven-nineteen leukemia) acted as a key regulator of super-enhancers, which are highly active distal CREs, across cancer types.