| Vol. 6.25 – 15 July, 2022 |
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| Arginine import was uniquely dependent on the cationic amino acid transporter SLC7A1, whose inhibition slowed HCC cell growth in vitro and in vivo. [Cell Metabolism] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| To investigate the impact of diphthamide biosynthesis protein 1 in hepatocellular carcinogenesis, scientists performed data mining from The Cancer Genome Atlas Liver Hepatocellular Carcinoma dataset. [Journal of Pathology] |
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| Investigators found that aspirin attenuated the phosphoglycerate mutase 1 (PGAM1) succinylation to suppress the PGAM1 enzymatic activities and glycolysis in hepatoma cells. [Acta Pharmacologica Sinica] |
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| Researchers identified circular dorsal ruffles-expressing cancer cell lines and investigated their cellular functions. [Cell Communication and Signaling] |
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| Significant apoptosis, hepatocyte nuclear factor alpha upregulation, and nuclear factor kappa B activation were observed in human-derived hepatocytes during endoplasmic reticulum stress. [Scientific Reports] |
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| In vitro experiments demonstrated that cell proliferation was significantly decreased in high-mobility group box 2 (HMGB2)-knockout hepatocytes. [Scientific Reports] |
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| Scientists characterized the transport/metabolic pathways in the hepatic disposition of PF-06835919, a first-in-class ketohexokinase inhibitor for the treatment of metabolic disorders and non-alcoholic steatohepatitis. [Drug Metabolism and Disposition] |
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| The authors explored whether or not caffeine’s function was related to glucose-regulated protein 78 (GRP78). Acute liver injury model was established by lipopolysaccharide (LPS)-treated L02 cells and in vivo administration of LPS/D-galactosamine in mice, then caffeine was pre-treated in L02 cells in mice. [Inflammation Research] |
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| Considering the critical role of hepatic stellate cell activation in hepatic fibrosis, scientists revealed the exact role of x-inactive-specific transcript (XIST) in liver fibrosis and its underlying mechanism. [Molecular and Cellular Biochemistry] |
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| Researchers explored the function of decursin on regulating hepatic stellate cells activation and hepatic fibrosis. [Biochemistry and Cell Biology] |
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| Scientists explain the main pathogenic mechanisms of benign liver tumors and how this knowledge could influence clinical practice. [Nature Reviews Gastroenterology & Hepatology] |
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| The authors discuss the putative metabolic mechanisms underlying the emergence of non-alcoholic fatty liver disease (NAFLD) or non-alcoholic steatohepatitis (NASH) after liver transplantation as well as optimal therapeutic approaches for recipients of liver transplants. [Nature Reviews Endocrinology] |
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| Inventiva announced the screening in the US of the first patient in its LEGEND Phase IIa combination trial with lanifibranor and empagliflozin in patients with non-alcoholic steatohepatitis (NASH) and type 2 diabetes (T2D). [Inventiva] |
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| Foundation for Liver Research – London, England, United Kingdom |
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| The Chinese University of Hong Kong – Hong Kong, China |
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| Pennsylvania State University – State College, Pennsylvania, United States |
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| University of Pittsburgh School of Medicine – Pittsburgh, Pennsylvania, United States |
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| La Jolla Institute for Immunology – La Jolla, California, United States |
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