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Chronic Effects of Two Rutile TiO2 Nanomaterials in Human Intestinal and Hepatic Cell Lines | Scientists investigated the cytotoxic effects of repeated exposure of relevant models of intestine and liver to two TiO2 nanomaterials differing in hydrophobicity for 24 hours, one week, and two weeks at concentrations ranging from 0.3 to 80 µg/cm2.
[Particle and Fibre Toxicology] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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Macrophages Evoke Autophagy of Hepatic Stellate Cells to Promote Liver Fibrosis in NAFLD Mice via the PGE2/EP4 Pathway | The authors found that liver macrophages were polarized toward type 2 during the progression of nonalcoholic steatohepatitis and liver fibrosis in both patients and nonalcoholic fatty liver disease (NAFLD) mice.
[Cellular and Molecular Life Sciences] |
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Roles of DKK3 in Cellular Adhesion, Motility, and Invasion through Extracellular Interaction with TGFBI | Researchers focused on the extracellular function of Dickkopf-related protein (DKK) 3 as a secreted protein, and identified transforming growth factor beta Induced protein ig-h3 (TGFBI) as a secreted protein interacting with DKK3.
[FEBS Journal] |
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MiR-129-5p Exerts Wnt Signaling-Dependent Tumor-Suppressive Functions in Hepatocellular Carcinoma by Directly Targeting Hepatoma-Derived Growth Factor HDGF | Scientists characterized the epigenetically regulated miR-129-5p regarding its functional effects and target genes to understand its relevance for hepatocellular carcinoma tumorigenesis.
[Cancer Cell International] |
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A New Liver-Regeneration Molecular Mechanism Involving Hepatic Stellate Cells, Kupffer Cells, and Glucose-Regulated Protein 78 as a New Hepatotrophic Factor | The authors focused on liver-regeneration mechanisms by the activation of hepatic stellate cells (HSC) and Kupffer cells (KC). It is known that the HSC-secreted Mac-2-binding protein glycan isomer (M2BPGi) activates KC in the fibrotic liver.
[Journal of Hepato-Biliary-Pancreatic Sciences] |
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METTL3-Mediated Macrophage Exosomal NEAT1 Contributes to Hepatic Fibrosis Progression through Sp1/TGF-β1/Smad Signaling Pathway | Scientists identified the roles of exosomal NEAT1 derived from macrophages on hepatic fibrosis and the underlying mechanisms.
[Cell Death Discovery] |
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Nanocurcumin and Curcumin Prevent N, N’-Methylenebisacrylamide-Induced Liver Damage and Promotion of Hepatic Cancer Cell Growth | Curcumin and nanocurcumin reduced HepG2 and Huh-7 cancer cell viability and increased apoptosis in the presence and absence of Acrylamide (AC), while AC alone promoted proliferation.
[Scientific Reports] |
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Prohaptoglobin Inhibits the Transforming Growth Factor-β-Induced Epithelial-to-Mesenchymal Transition In Vitro by Increasing Smad1/5 Activation and Suppressing the Smad2/3 Signaling Pathway in SK-Hep1 Liver Cancer Cells | Researchers demonstrated that prohaptoglobin stimulated Smad1/5 activation via ALK1, a transforming growth factor-β (TGF-β) type I receptor, in endothelial cells, suggesting that proHp played a role in TGF-β signaling.
[PLoS One] |
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Protective Effects of Epigallocatechin-3-O-Gallate Combined with Organic Selenium against Transforming Growth Factor-Beta 1-Induced Fibrosis in LX-2 Cells | Scientists investigated the protective effects and possible mechanism of epigallocatechin-3-o-gallate combined with organic selenium in transforming growth factor-β1-activated LX-2 cells.
[Journal of Food Biochemistry] |
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Chemical Investigations and Cytotoxic Effects of Metabolites from Antrodia camphorata against Human Hepatocellular Carcinoma Cells | Investigators identified fermented metabolic components from the mycelium of A. camphorata KH37 and explored their anti-hepatoma potentials with study models of human hepatoblastoma cell lines.
[Natural Product Research] |
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The Role of IFNL4 in Liver Inflammation and Progression of Fibrosis | The authors summarize the genetic data available for the IFNL3/IFNl4 loci and provide an in-depth discussion of causality.
[Genes & Immunity] |
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Adial Pharmaceuticals Announces Research Collaboration with the Medical College of Wisconsin to Advance Purnovate’s Adenosine Compounds as Potential Treatments for Diabetes and NASH | Adial Pharmaceuticals, Inc. announced that Purnovate, Inc. has entered into a research collaboration with the Medical College of Wisconsin, a leading medical school, and Dr. John Auchampach, PhD, Professor and Vice Chair of the Department of Pharmacology and Toxicology.
[ADial Pharmaceuticals Inc.] |
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| June 15 – 17, 2022
Lyon, France |
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| The University of Texas Southwestern Medical Center – Dallas, Texas, United States |
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| University of Gothenburg – Gothenburg, Sweden |
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| National Institute for Health and Medical Research – Strasbourg, France |
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| | Baylor College of Medicine – Houston, Texas, United States |
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| | CRUK Beatson Institute for Cancer Research – Glasgow, Scotland, United Kingdom |
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