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| The authors used spatially resolved single-cell RNA sequencing to study the dynamics of mouse liver regeneration after acute acetaminophen intoxication.
[Cell Stem Cell] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The authors reported that diploid hepatocytes showed more than seven-fold higher annual birth rates than polyploid hepatocytes.
[Cell Systems] |
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| The authors reported that exposure of primary murine hepatocytes to hepatocyte growth factor stimulated eotaxin expression.
[Cell Death & Disease] |
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| The authors reported that high expression of DNAJC24 shortened survival in patients with HCC by immunohistochemical staining of 167 paired hepatocellular carcinomas and paraneoplastic tissues, as well as data from public databases.
[Cell Death & Disease] |
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| Hepatic B cell leukemia-3 (Bcl-3) overexpression in hepatocytes protected from ALF with massive hepatocyte apoptosis induced by the anti-FAS antibody Jo2. .
[Cell Death & Disease] |
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| The authors reported that ectopic expression of ubiquitin-specific peptidase 53 (USP53) inhibited the proliferation, migration and invasion, and induced the apoptosis of HCC cells.
[Oncogenesis] |
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| Scientists reported that after chronic-plus-binge ethanol feeding, hepatocyte-specific mesencephalic astrocyte-derived neurotrophic factor (MANF) knockout mice displayed more severe hepatic steatosis and liver injury than wild-type control mice.
[Acta Pharmacologica Sinica] |
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| Scientists assessed whether in vitro recombinant adeno-associated virus (AAV) transduction assays in cultured primary hepatocytes from mice, nonhuman primates (NHP), and humans could model in vivo liver-directed AAV expression of valoctocogene roxaparvovec.
[Molecular Therapy-Methods & Clinical Development] |
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| Scientists demonstrated the efficiency of proliferating primary rat hepatocytes in cell fibers not only as cell-based sensors to detect drugs that damage hepatic functions and hepatocellular processes but also as transplants to improve the plasma albumin concentrations of congenital analbuminemia.
[Scientific Reports] |
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| Scientists discuss various historical aspects of 3D organoid culture, how it has been applied to the hepatobiliary system, and how organoid technology intersects with the emerging global field of liver regenerative medicine.
[Hepatology] |
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| Revive Therapeutics Ltd. announced that in light of the growing cases of acute hepatitis in children reported by the WHO, the company will advance its drug pipeline for inflammatory liver disorders including Bucillamine in the prevention of ischemia-reperfusion injury during liver transplantation.
[Revive Therapeutics Ltd.] |
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| Eureka Therapeutics, Inc. and City of Hope announced that City of Hope treated the first patient with GPC3-positive advanced hepatocellular carcinoma, the predominant type of liver cancer, with ECT204, an experimental T cell therapy.
[Eureka Therapeutics (EurekAlert!)] |
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| October 3 – 4, 2022
San Diego, California, United States |
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| | German Cancer Research Center in the Helmholtz Association – Heidelberg, Germany |
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| | La Jolla Institute for Immunology – La Jolla, California, United States |
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| | Norwegian University of Science and Technology -Trondheim, Norway |
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| | National Institutes of Health – Bethesda, Maryland, United States |
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| | Memorial Sloan Kettering Cancer Center – New York, New York, United States |
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