Hepatic Cell News Volume 6.30 | Aug 19 2022

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    2022-08-19 | HCN 6.30


    Hepatic Cell News by STEMCELL Technologies
    Vol. 6.30 – 19 August, 2022
    TOP STORY

    Targeting FAPα-Expressing Hepatic Stellate Cells Overcomes Resistance to Anti-Angiogenics in Colorectal Cancer Liver Metastasis Models

    The authors found that the occurrence of vessel co-option in bevacizumab-resistant colorectal cancer liver metastasis xenografts was associated with increased expression of fibroblast activation protein alpha in the co-opted hepatic stellate cells.
    [Journal of Clinical Investigation]

    AbstractFull ArticleGraphical Abstract

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    Guiding Irregular Nuclear Morphology on Nanopillar Arrays for Malignancy Differentiation in Tumor Cells

    Researchers employed nanopillar arrays to guide subnuclear features into ordered patterns, enabling their quantification as a strong indicator of cell malignancy.
    [Nano Letters]

    AbstractGraphical Abstract

    Centriole Signaling Restricts Hepatocyte Ploidy To Maintain Liver Integrity

    Scientists showed that hepatocytes accumulated centrioles during cycles of polyploidization in vivo.
    [Genes & Development]

    Abstract

    Inhibition of Arid1a Increases Stem/Progenitor Cell-Like Properties of Liver Cancer

    Investigators demonstrated that Arid1a knockout may have resulted in states of different cell differentiation, as indicated by single-cell RNA sequencing analysis.
    [Cancer Letters]

    Abstract

    ACSL4-Dependent Ferroptosis Does Not Represent a Tumor-Suppressive Mechanism but ACSL4 Rather Promotes Liver Cancer Progression

    Preventing ferroptotic cell death in hepatocytes by deleting Acsl4 did not increase the formation of HCC. Furthermore, Acsl4-deficient livers displayed less fibrosis and proliferation, especially in an HCC model of toxic damage.
    [Cell Death & Disease]

    Full Article

    Loss of FOXA2 Induces ER Stress and Hepatic Steatosis and Alters Developmental Gene Expression in Human iPSC-Derived Hepatocytes

    The authors used FOXA2 mutant induced pluripotent stem cell (iPSC) lines to understand the role of FOXA2 on the development and function of human hepatocytes.
    [Cell Death & Disease]

    Full Article

    The Spike of SARS-CoV-2 Promotes Metabolic Rewiring in Hepatocytes

    Investigators demonstrated that hepatocytes were susceptible to infection in different models: primary hepatocytes derived from humanized angiotensin-converting enzyme-2 mice and primary human hepatocytes.
    [Communications Biology]

    Full Article

    Ribosomal Protein L22-Like1 (RPL22L1) Mediates Sorafenib Sensitivity via ERK in Hepatocellular Carcinoma

    Scientists identified a novel candidate oncogene, RPL22L1, which was markedly elevated in HCC and contributed to HCC malignancy and adverse patient survival.
    [Cell Death Discovery]

    Full Article

    Insights on the Antiviral Mechanisms of Action of the TLR1/2 Agonist Pam3CSK4 in Hepatitis B Virus (HBV)-Infected Hepatocytes

    Researchers used in vitro models of HBV-infected cells, based on both primary human hepatocytes and the non-transformed HepaRG cell line to investigate the MoA of Pam3SCK4 and identify relevant combinations with other approved or investigational drugs.
    [Antiviral Research]

    Abstract

    Efficient Engraftment and Viral Transduction of Human Hepatocytes in an FRG Rat Liver Humanization Model

    Approaches were developed for gene delivery through viral transduction of human hepatocytes either in vivo, or in vitro prior to engraftment, providing a novel platform to study liver disease and hepatocyte-targeted therapies.
    [Scientific Reports]

    Full Article

    Salidroside Alleviates Hepatic Ischemia–Reperfusion Injury during Liver Transplant in Rat through Regulating TLR-4/NF-κB/NLRP3 Inflammatory Pathway

    Investigators used both in vivo and in vitro assays to assess the effect and mechanisms of salidroside on hepatic ischemia-reperfusion injury.
    [Scientific Reports]

    Full Article

    Perfusion Culture of Multi-Layered HepG2 Hepatocellular Carcinoma Cells in a Pressure-Driven Microphysiological System

    Researchers reported the perfusion culture of a multi-layered tissue composed of HepG2 cells in a pressure-driven microphysiological system, which they developed previously as a multi-throughput perfusion culture platform.
    [Journal of Bioscience and Bioengineering]

    AbstractGraphical Abstract

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    REVIEWS

    Targeted Therapeutics and Novel Signaling Pathways in Non-Alcohol-Associated Fatty Liver/Steatohepatitis (NAFL/NASH)

    The authors discuss recent developments in etiology and prospective therapeutic targets, as well as pharmacological candidates in pre-clinical trials and patents, with a focus on diabetes, hepatic lipid metabolism, inflammation, and fibrosis.
    [Signal Transduction and Targeted Therapy]

    Full Article

    The Role of lincRNA-p21 in Regulating the Biology of Cancer Cells

    Scientists highlight the emerging roles of lincRNA-p21 in cancer cell regulation. Various types of cancers, including colorectal carcinoma, HCC, and non-small cell lung carcinoma aberrantly express lincRNA-p21.
    [Human Cell]

    Abstract

    INDUSTRY AND POLICY NEWS

    89bio Announces Completion of Enrollment in ENLIVEN, the Phase IIb Trial of Pegozafermin for the Treatment of NASH

    89bio, Inc. announced that it has completed enrollment in ENLIVEN, the Phase IIb trial of pegozafermin for the treatment of non-alcoholic steatohepatitis (NASH).
    [89bio, Inc.]

    Press Release

    FEATURED EVENT

    Angiotensin

    November 13 – 18, 2022
    Ventura, California, United States

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    JOB OPPORTUNITIES

    Postdoctoral Associate – Epigenomic Gegulation of Metabolism

    Baylor College of Medicine – Houston, Texas, United States

    Senior Investigator – Cancer Research

    NIH National Cancer Institute – Bethesda, Maryland, United States

    Postdoctoral Fellow – Liver Injury

    University of Kansas Medical Center – Kansas City, Kansas, United States

    Research Scientist – Inflammation

    Gilead Sciences, Inc. – Foster City, California, United States

    Faculty Position – Cancer Biology

    Mayo Clinic – Scottsdale, Arizona, United States

    > See All Jobs

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