 | | Vol. 7.31 – 25 August, 2023 |
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| Investigators systematically quantified a perimetastatic capsule’s extent and cellular composition in 263 patients with colorectal cancer liver metastases to investigate its clinical significance and origin.
[Nature Communications] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Adults with positive HBsAg for at least 6 months were recruited from 12 medical centers. Participants underwent dual-elasto evaluations.
[Hepatology] |
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| To define the metabolic phenotype in normal proliferating hepatocytes, scientists induced cell proliferation in the liver by three distinct stimuli: liver regeneration by partial hepatectomy and hepatic hyperplasia induced by two direct mitogens, lead nitrate or triiodothyronine.
[Hepatology] |
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| Researchers reported that F-box protein (FBXO) 28 was a critical negative regulator of migration, invasion, and metastasis in human HCC in vitro and in vivo.
[Oncogene] |
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| Scientists investigated the effects of acute alcohol intoxication on inflammation-related markers in hepatic and systemic venous plasma in people with alcohol-related liver disease, non-alcoholic fatty liver disease, and healthy controls.
[Liver International] |
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| The authors investigated the roles of exosomal miRNAs from Sal-treated hepatocytes in hepatic stellate cell activation as well as liver fibrosis.
[Cell Death Discovery] |
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| Scientists proposed a hepatocyte culture model for the rapid evaluation of drug biliary excretion using permeation assays.
[Communications Biology] |
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| Researchers tested the liability for cytochrome P450 (CYP) induction of a diverse set of yes-associated protein (YAP)/TEA domain transcription factor (TEAD) inhibitors with different modes of action and TEAD isoform selectivity profiles in monolayers and 3D spheroids of primary human hepatocytes.
[Biochemical Pharmacology] |
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| To address the functional role of glucocorticoid receptor (GR) in the adult liver, the authors used an acute hepatocyte-specific GR knockout model to study temporal hepatic lipid metabolism governed by GR at several pre- and postprandial circadian timepoints.
[Endocrinology] |
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| Through extensive statistical analyses, using liver hepatocellular carcinoma (LIHC) patient databases, investigators observed that coiled-coil domain-containing protein 115 (CCDC115) expression significantly increased in tumor tissues of LIHC patients.
[Heliyon] |
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| Scientists systematically collected relevant literature in the past five years on the intervention of natural polysaccharides in alcoholic liver disease and reviewed the pharmacological activities and potential mechanisms of action.
[International Journal of Biological Macromolecules] |
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| Dr. Wanqing Liu received a $3 million, five-year award from the National Institute of Environmental Health Sciences of the National Institutes of Health.
[Wayne State University] |
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| A recent $9.57 million grant awarded to researchers with the UC San Diego NAFLD Research Center at University of California San Diego School of Medicine will support a clinical trial to study a new treatment option for patients with the disease.
[UC San Diego] |
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| October 11 – 14, 2023
Ottawa, Ontario, Canada |
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| | Cedars-Sinai – Los Angeles, California, United States |
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| | University of South California – Los Angeles, California, United States |
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| | Columbia University Irving Medical Center – New York City, New York, United States |
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| | Beatson Institute – Glasgow, Scotland, United Kingdom |
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| | CRUK Beatson Institute – Glasgow, Scotland, United Kingdom |
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