 | | Vol. 10.18 – 10 May, 2022 |
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Landscape of Helper and Regulatory Antitumor CD4+ T Cells in Melanoma | Researchers performed an in-depth analysis of the phenotype and tumour specificity of CD4+ T cells infiltrating human melanoma specimens, finding that exhausted cytotoxic CD4+ T cells could be directly induced by melanoma cells through recognition of HLA class II-restricted neoantigens.
[Nature] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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Intermittent PI3Kδ Inhibition Sustains Anti-Tumor Immunity and Curbs irAEs | Scientists assessed the effects of the phosphoinositide 3-kinase δ (PI3Kδ) inhibitor AMG319 in human patients with head and neck cancer in a neoadjuvant, double-blind, placebo-controlled randomized Phase II trial.
[Nature] |
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Claudin18.2-Specific CAR T Cells in Gastrointestinal Cancers: Phase I Trial Interim Results | The authors reported the interim analysis results of an ongoing, open-label, single-arm, Phase I clinical trial of CLDN18.2-targeted CAR T cells in patients with previously treated, CLDN18.2-positive digestive system cancers.
[Nature Medicine] |
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Prioritization of Autoimmune Disease-Associated Genetic Variants That Perturb Regulatory Element Activity in T Cells | Investigators performed high-throughput allele-specific reporter assays to prioritize disease-associated variants for five autoimmune diseases. They identified 60 putatively causal variants that enriched for statistically fine-mapped variants by up to 57.8-fold.
[Nature Genetics] |
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Interleukin-6 Blockade Abrogates Immunotherapy Toxicity and Promotes Tumor Immunity | Researchers performed a deep immune analysis of intestinal, colitis, and tumor tissue from immune checkpoint blockade-treated patients with parallel studies in preclinical models.
[Cancer Cell] |
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An Activation to Memory Differentiation Trajectory of Tumor-Infiltrating Lymphocytes Informs Metastatic Melanoma Outcomes | The authors applied advanced functional genomics to interrogate 9,000 human tumors and multiple single-cell sequencing sets using benchmarked T cell states, comprehensive T cell differentiation trajectories, human and mouse vaccine responses, and other human tumor-infiltrating lymphocytes.
[Cancer Cell] |
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Risk Assessment with Low Pass Whole Genome Sequencing of Cell Free DNA before CD19 CAR T Cells for Large B Cell Lymphoma | Investigators evaluated low pass whole genome sequencing of cell free DNA prior to CD19 CAR T cell therapy as a new approach for risk stratification.
[Blood] |
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A Fluorogenic Probe for Granzyme B Enables In-Biopsy Evaluation and Screening of Response to Anticancer Immunotherapies | Scientists reported the rational design of a fluorogenic peptide able to detect picomolar concentrations of active granzyme B as a biomarker of immune-mediated anticancer action.
[Nature Communications] |
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A Systematic Comparison of FOSL1, FOSL2 and BATF-Mediated Transcriptional Regulation during Early Human Th17 Differentiation | Researchers characterized the human-specific roles of three AP-1 transcription factors, FOSL1, FOSL2 and BATF, during early stages of Th17 differentiation.
[Nucleic Acids Research] |
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Loss of RBMS1 Promotes Anti-Tumor Immunity through Enabling PD-L1 Checkpoint Blockade in Triple-Negative Breast Cancer | The authors reported that the RNA binding protein RBMS1 was prevalent among immune-cold triple-negative breast cancer (TNBC) and provided a new immunotherapeutic strategy against TNBC by targeting RBMS1.
[Cell Death & Differentiation] |
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CXCL14 Promotes a Robust Brain Tumor-Associated Immune Response in Glioma | Investigators used patient-derived glioma cultures and an immunocompetent murine model for malignant glioma to analyze the ability of tumor-intrinsic factors to promote a CD8+ T cell response.
[Clinical Cancer Research] |
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Targeting Tissue-Resident Memory CD8+ T Cells in the Kidney Is a Potential Therapeutic Strategy to Ameliorate Podocyte Injury and Glomerulosclerosis | Scientists found that renal tissue displayed high abundance of tissue-resident lymphocytes and the proportion of CD8+ tissue-resident memory T cells was significantly increased in the kidney from patients and mice with focal segmental glomerulosclerosis, diabetic kidney disease, and lupus nephritis.
[Molecular Therapy] |
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Ceramide Synthase 6 Impacts T Cell Allogeneic Response and Graft-versus-Host Disease through Regulating N-RAS/ERK Pathway | Researchers found that genetic or pharmacologic targeting of ceramide synthase 6 (CerS6) prevented and reversed chronic graft-vs-host-disease (GVHD). Blockade of CerS6 restrained donor T cells from migrating into GVHD target organs and preferentially reduced activation of donor CD4 T cells.
[Leukemia] |
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Tumor Immunotherapy: Lessons from Predator–Prey Theory | The authors describe the basic tenets of predator–prey theory as applied to ‘predation’ by immune cells and the ‘extinction’ of cancer cells.
[Nature Reviews Immunology] |
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The Immunology of Multiple Sclerosis | Scientists present findings that begin to question the exclusivity of an antigen-specific cause of multiple sclerosis and highlight how seemingly distinct immune cell types can share common functions that drive disease.
[Nature Reviews Immunology] |
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The Clinical Progress of mRNA Vaccines and Immunotherapies | Investigators review the clinical progress of mRNA therapy as well as provide an overview and future outlook of the transformative technology behind these mRNA-based drugs.
[Nature Biotechnology] |
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Harpoon Therapeutics and Roche to Collaborate on Clinical Trials to Study Novel Immuno-Oncology Combination for Small Cell Lung Cancer | Harpoon Therapeutics, Inc. announced that it has entered into a clinical supply agreement with Roche to supply atezolizumab for use in the Company’s HPN328, a DLL3 targeting TriTAC®, clinical development program.
[Harpoon Therapeutics, Inc.] |
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Gilead and Dragonfly Announce Strategic Research Collaboration to Develop Natural Killer Cell Engagers in Oncology and Inflammation | Gilead Sciences, Inc. and Dragonfly Therapeutics announced a collaboration designed to advance a number of Dragonfly’s novel NK cell engager-based immunotherapies for oncology and inflammation indications.
[Gilead Sciences, Inc.] |
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Umoja Biopharma Announces Activation of First ENLIGHTen Phase I Trial Site in Study of UB-TT170, a TumorTag that Targets Folate Receptors to Mark Tumors for Clearance by CAR T Cells | Umoja Biopharma, Inc. announced the Seattle Children’s activation of the Phase I ENLIGHTen clinical trial in patients with osteosarcoma to assess the safety and tolerability of autologous “universal” CAR T cells when administered with UB-TT170, the company’s proprietary small molecule fluorescein tag.
[Umoja Biopharma, Inc.] |
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Boehringer Ingelheim and OSE Immunotherapeutics Announce First Patient Dosed in a Phase I Expansion Trial of SIRPα Antagonist Monoclonal Antibody BI 765063, Targeting Myeloid Cells in Immuno-Oncology | Boehringer Ingelheim and OSE Immunotherapeutics SA announced that Boehringer Ingelheim has obtained exclusive rights to BI 765063, a first-in-class SIRPα inhibitor on the SIRPα/ CD47 myeloid pathway being evaluated in patients with recurrent/metastatic hepatocellular carcinoma.
[OSE Immunotherapeutics SA] |
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| 13 – 14 June, 2022
London, England, United Kingdom |
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| | STEMCELL Technologies, Inc. – Vancouver, British Columbia, Canada |
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| | Ragon Institute of MGH, MIT and Harvard – Cambridge, Massachusetts, United States |
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| | Cancer Research Center of Lyon – Lyon, France |
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| | The Pirbright Institute – Pirbright, England, United Kingdom |
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| | New York University College of Dentistry – New York, New York, United States |
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Cancer Stem Cell News
Cell Therapy News
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Endothelial Cell News
ESC & iPSC News
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Hepatic Cell News
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Immune Regulation News
Intestinal Cell News
Mammary Cell News
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