Human Immunology News Volume 10.39 | Oct 4 2022

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    2022-10-04 | HIN 10.39


    Human Immunology News by STEMCELL Technologies
    Vol. 10.39 – 4 October, 2022
    TOP STORY

    Inhibition of the CtBP Complex and FBXO11 Enhances MHC Class II Expression and Anti-Cancer Immune Responses

    Scientists identified that the C-terminal binding protein complex transcriptionally repressed MHC class II pathway genes, while the E3 ubiquitin ligase complex component FBXO11 mediated degradation of CIITA, the principal transcription factor regulating MHC class II expression.
    [Cancer Cell]

    AbstractGraphical Abstract
    Free E-Book: Genome Editing Applications for Disease Modeling and Cell Therapy.
    PUBLICATIONSRanked by the impact factor of the journal

    Ancestry-Driven Recalibration of Tumor Mutational Burden and Disparate Clinical Outcomes in Response to Immune Checkpoint Inhibitors

    Using two clinical cohorts, researchers investigated the interplay between genetic ancestry, tumor mutational burden, and tumor-only versus tumor-normal paired sequencing in solid tumors.
    [Cancer Cell]

    Full ArticleGraphical Abstract

    CAR Density Influences Antitumoral Efficacy of BCMA CAR T Cells and Correlates With Clinical Outcome

    Functional and transcriptional studies demonstrated that CAR T cells with high expression of the CAR construct showed an increased tonic signaling with up-regulation of exhaustion markers and increased in vitro cytotoxicity but a decrease in in vivo bone marrow infiltration.
    [Science Advances]

    Full Article

    Regulation of Autoimmune Disease Progression by Pik3ip1 through Metabolic Reprogramming in T Cells and Therapeutic Implications

    Investigators showed that phosphatidylinositide 3-kinase interacting protein 1 (Pik3ip1) was notably down-regulated in several major autoimmune diseases through a previously unidentified mechanism mediated by interleukin-21/p38 mitogen-activated protein kinase/a disintegrin and metalloprotease-17 pathway.
    [Science Advances]

    Full Article

    Interleukin-22 Regulates Neutrophil Recruitment in Ulcerative Colitis and Is Associated with Resistance to Ustekinumab Therapy

    Scientists showed that IL-22 regulated pro-inflammatory pathways were involved in microbial recognition, cancer and immune cell chemotaxis, most prominently those involving CXCR2+ neutrophils.
    [Nature Communications]

    Full Article

    DSTYK Inhibition Increases the Sensitivity of Lung Cancer Cells to T Cell–Mediated Cytotoxicity

    Researchers identified DSTYK, a dual serine/threonine and tyrosine non-receptor protein kinase, as a novel actionable target altered in non-small cell lung cancer.
    [Journal of Experimental Medicine]

    Abstract

    BACH2 Restricts NK Cell Maturation and Function, Limiting Immunity to Cancer Metastasis

    Investigators showed that BACH2 acted as an intrinsic negative regulator of NK cell maturation and function. BACH2 was expressed within developing and mature NK cells and promotes the maintenance of immature NK cells by restricting their maturation in the presence of weak stimulatory signals.
    [Journal of Experimental Medicine]

    Abstract

    FOXP3+ Macrophage Represses Acute Ischemic Stroke-Induced Neural Inflammation

    Scientists reported that FOXP3, the key immune-repressive transcription factor of Tregs, was conditionally expressed in macrophages in stroke lesion.
    [Autophagy]

    Abstract

    Establishment of a Humanized Animal Model of Systemic Sclerosis in Which T Helper-17 Cells From Patients With Systemic Sclerosis Infiltrate and Cause Fibrosis in the Lungs and Skin

    Researchers introduced a novel animal model for systemic sclerosis (SSc) using immunodeficient mice injected with peripheral blood mononuclear cells from SSc patients.
    [Experimental & Molecular Medicine]

    Full Article
    Dr. Kristina McBurney and Leanna Bedell discuss how you can use social media to advance your scientific career. Watch now.
    REVIEWS

    Sex Differences in Mast Cell–Associated Disorders: A Life Span Perspective

    Investigators review sex differences in human mast cell-associated diseases and animal models, and the underlying biological mechanisms driving these sex differences, which include adult gonadal sex hormones on mast cell activity and development.
    [Cold Spring Harbor Perspectives in Biology]

    Abstract
    INDUSTRY AND POLICY NEWS

    Cue Biopharma Granted FDA Fast Track Designation for CUE-101 for the Treatment of Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma

    Cue Biopharma, Inc. announced that the FDA has granted Fast Track designation to CUE-101, its lead clinical drug candidate from the CUE-100 series of interleukin 2-based biologics, for the treatment of patients with human papilloma virus recurrent/metastatic head and neck squamous cell carcinoma.
    [Cue Biopharma, Inc.]

    Press Release
    FEATURED EVENT

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    January 23 – 25, 2022
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    JOB OPPORTUNITIES

    Research Fellow – CAR T Cells from iPSCs

    Memorial Sloan Kettering Cancer Center – New York, New York, United States

    Research Scientist – CRISPR Tools in Gene & Cell Therapies

    Alia Therapeutics – Trento, Italy

    Assistant Professor – Human Infection

    Massachusetts General Hospital – Boston, Massachusetts, United States

    Postdoctoral Associate – Chromosomal Architecture

    University of Miami – Miami, Florida, United States

    Postdoctoral Fellow – Psychoneuroimmunology of Respiratory Disorders

    University of Alberta – Edmonton, Alberta, Canada

    > See All Jobs

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