Regulation of Autoimmune Disease Progression by Pik3ip1 through Metabolic Reprogramming in T Cells and Therapeutic Implications

Investigators showed that phosphatidylinositide 3-kinase interacting protein 1 (Pik3ip1), a newly identified negative immune regulator, was notably down-regulated in several major autoimmune diseases through a previously unidentified mechanism mediated by interleukin-21/p38 mitogen-activated protein kinase/a disintegrin and metalloprotease-17 pathway.