 | | Vol. 14.22 – 17 June, 2022 |
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| The authors used genetic tracing to identify microbiota-induced peripheral Treg cells and found that many of their distinguishing features were Foxp3 independent.
[Immunity] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators evaluated the contribution of the NLRP3 inflammasome in right ventricular (RV)-macrophages to pulmonary arterial hypertension-RV failure.
[American Journal of Respiratory and Critical Care Medicine] |
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| Researchers demonstrated that tumor microenvironment reprogramming set the stage for response to anti-programmed cell death protein 1 (PD1) immunotherapy, and the combination resulted in tumor regression in a 4T1 breast cancer mouse model that was resistant to PD1 blockade.
[Science Translational Medicine] |
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| Steroid nuclear receptor coactivator 2 (SRC2) was dispensable for the development of thymic Tregs, whereas naive CD4+ T cells from mice deficient of SRC2 specific in Tregs displayed defective Treg differentiation.
[Science Advances] |
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| The authors demonstrated that B Cell activation reprogramed the tricarboxylic acid cycle and boosted the expression of fumarate hydratase, leading to decreased cellular fumarate abundance.
[Nature Chemical Biology] |
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| Scientists showed that the clinically approved compound ursodeoxycholic acid, by degrading TGF-β, enhanced antitumor immunity through restraining Treg cell differentiation and activation in tumor-bearing mice.
[Nature Communications] |
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| Investigators demonstrated that a long-acting form of recombinant human interleukin-7 fused with hybrid Fc (rhIL-7-hyFc) promoted proliferation, persistence, and cytotoxicity of human CAR T cells in xenogeneic mouse models and murine CAR T cells in syngeneic mouse models, resulting in long-term tumor-free survival.
[Nature Communications] |
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| Scientists developed a novel mouse strain to divert IL-2 production, allowing identification of contextual outcomes. Network analysis identified priority access for Tregs and a competitive fitness cost of IL-2 production among both Tregs and conventional CD4 T cells.
[Journal of Experimental Medicine] |
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| Researchers reported that regional intravascular infusion of ODN2395 into mice with liver metastasis partially eliminated liver myeloid-derived suppressor cells (MDSCs) and reprogrammed residual MDSC.
[Cancer Gene Therapy] |
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| The authors investigated whether JAK2 gene knockout affected corneal allograft rejection through regulation of dendritic cell-induced T cell immune tolerance.
[Cell Death Discovery] |
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| Investigators developed a novel immune-enhanced tumor organoid system to study factors affecting immune checkpoint blockade response.
[Scientific Reports] |
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| Researchers explored the protective effects of this Mebendazole against DSS-induced colitis in a murine model either alone or in combination with Sulfasalazine, a standard therapy for ulcerative colitis.
[Scientific Reports] |
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| The authors provide an overview of selected emerging therapies that predominantly target processes within the central nervous system (CNS) that are thought to be involved in limiting non-relapsing, progressive disease injury or promoting tissue repair.
[Nature Reviews Neurology] |
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| To understand the mechanisms of bone damage in rheumatoid arthritis, it is important to clarify how the immune system promotes the tissue-destructive properties of synovial fibroblasts and influences bone cells.
[Nature Reviews Rheumatology] |
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| There is evidence to suggest that autoimmune diseases can be suppressed by anti-inflammatory bioactive lipids LXA4, resolvins, protecting, and maresins.
[European Journal of Clinical Nutrition] |
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| OSE Immunotherapeutics SA announced that the company is one of the first biotech startup companies selected by Microsoft France to be a privileged partner of its support program for French Biotech & Deeptech Startups.
[OSE Immunotherapeutics SA] |
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| The US FDA approved Olumiant oral tablets to treat adult patients with severe alopecia areata, an autoimmune disorder in which the body attacks its own hair follicles, causing hair to fall out, often in clumps.
[US FDA] |
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| September 11 – 13, 2022
Lisbon, Portugal |
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| | New York Blood Center – New York, New York, United States |
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| | Boston Children’s Hospital – Boston, Massachusetts, United States |
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| | Uppsala University – Uppsala, Sweden |
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| | University of Pittsburgh School of Medicine – Pittsburgh, Pennsylvania, United States |
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| | University of North Dakota – Grand Forks, North Dakota, United States |
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