Regional Infusion of a Class C TLR9 Agonist Enhances Liver Tumor Microenvironment Reprogramming and MDSC Reduction to Improve Responsiveness to Systemic Checkpoint Inhibition

Researchers reported that regional intravascular infusion of ODN2395 into mice with liver metastasis partially eliminated liver myeloid-derived suppressor cells (MDSCs) and reprogrammed residual MDSC.