 | | Vol. 14.33 – 9 September, 2022 |
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| The authors identified a new class of RORγt+ antigen-presenting cells, dubbed Thetis cells, with transcriptional features of both medullary thymic epithelial cells and dendritic cells, comprising four major sub-groups.
[Nature] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Using IL-23R-deficient Th1-like cells, scientists demonstrated that IL-23R was required for the development of a highly colitogenic phenotype.
[Immunity] |
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| Researchers showed that lactate was able to increase stemness of CD8+ T cells and augment anti-tumor immunity.
[Nature Communications] |
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| Results in mice showed that CD69 expression on Treg cells increased survival after left-anterior-descending coronary artery-ligation.
[Journal of Clinical Investigation] |
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| NRP1+ T helper cells, absent in non-regulatory T cell subsets in normal mice, appeared in models of systemic autoimmune disease and strongly correlated with systemic autoimmune disease symptoms.
[EMBO Molecular Medicine] |
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| Researchers demonstrated that the IFNγ-driven, tumor cell intrinsic expression of the class II transactivator CIITA was required for activation of a tumor-specific CD4 T-cell response and BCG-induced tumor immunity.
[Cancer Immunology Immunotherapy] |
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| The authors showed that while glucose at a high concentration promoted intestinal inflammation, it suppressed colitis at a moderate dose, which increased the proportion of intestinal Treg cells but did not affect effector CD4+ T cells.
[iScience] |
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| Chimeras with cannabinoid receptor 1 (CB1)-/- in immune cells showed exacerbation in diet-induced obesity combined with infiltration of bone-marrow derived macrophages to the brain and visceral adipose tissue, elevated food intake, and increased glucose intolerance.
[iScience] |
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| Researchers investigated whether splenectomy influenced the degree of skin inflammation and pathology in imiquimod-treated mice.
[Scientific Reports] |
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| The intraperitoneal injection of streptozocin was used to induce a type 1 diabetes mellitus mouse model; the blood glucose, body weight, and the expression of inflammatory factors in the kidney were measured.
[Scientific Reports] |
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| Scientists review of the cardiovascular inflammatory and immune functions of γδ T17 cells in order to understand their role in cardiovascular disease, which may be the key to developing new clinical applications.
[Journal of Leukocyte Biology] |
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| | Pfizer, Inc. announced that the FDA accepted for filing the New Drug Application for ritlecitinib for adults and adolescents 12 years of age and older with alopecia areata.
[Pfizer, Inc.] |
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| September 30, 2022
Clayton, Victoria, Australia |
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| | Louisiana State University – Baton Rouge, Louisiana, United States |
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| | STEMCELL Technologies, Inc. – Vancouver, British Columbia, Canada |
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| | Melanoma Institute Australia – Sydney, Australia |
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| | Columbia University – New York, New York, United States |
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| | University of Michigan – Ann Arbor, Michigan, United States |
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