Immune Regulation News Volume 14.36 | Oct 14 2022

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    2022-10-14 | IRN 14.36


    Immune Regulation News by STEMCELL Technologies
    Vol. 14.36 – 14 October, 2022
    TOP STORY

    The Primordial Differentiation of Tumor-Specific Memory CD8+ T Cells As Bona Fide Responders to PD-1/PD-L1 Blockade in Draining Lymph Nodes

    Using multiple preclinical tumor models, researchers revealed that a subset of tumor-specific CD8+ cells in the tumor-draining lymph nodes was not functionally exhausted but exhibited canonical memory characteristics.
    [Cell]

    Abstract
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    Tumor Microbiome Links Cellular Programs and Immunity in Pancreatic Cancer

    Investigators used SAHMI to interrogate tumor-microbiome interactions in two human pancreatic cancer cohorts. They identified somatic-cell-associated bacteria in a subset of tumors and their near absence in nonmalignant tissues.
    [Cancer Cell]

    AbstractFull ArticleGraphical Abstract

    Evolution of Antigen-Specific Follicular Helper T Cell Transcription from Effector Function to Memory

    Using indexed single-cell molecular strategies, scientists revealed a skewed intraclonal assortment of higher-affinity T cell receptors and the distinct molecular programming of the localized TFH compartment compared with emigrant conventional effector TH cells.
    [Science Immunology]

    Abstract

    Antigen-Specific Depletion of CD4+ T Cells by CAR T Cells Reveals Distinct Roles of Higher- and Lower-Affinity TCRs during Autoimmunity

    Integration of improvements in CAR engineering with TCR repertoire analysis was critical for interrogating in vivo the role of TCR affinity in autoimmunity.
    [Science Immunology]

    Full Article

    TGF-β-Dependent Lymphoid Tissue Residency of Stem-Like T Cells Limits Response to Tumor Vaccine

    Investigators showed that in a mouse melanoma model, in the tumor-draining lymph nodes rather than in the tumors themselves, stem-like CD8+ T cells differentiate into TRMs in a TGF-β and tumor antigen dependent manner.
    [Nature Communications]

    Full Article

    Erythropoietin Signaling in Peripheral Macrophages Is Required for Systemic β-Amyloid Clearance

    Researchers showed that erythropoietin increased phagocytic activity, levels of Aβ-degrading enzymes, and Aβ clearance in peripheral macrophages via PPARγ.
    [EMBO Journal]

    AbstractGraphical Abstract

    Inhibition of FOXP3 by Stapled Alpha-Helical Peptides Dampens Regulatory T Cell Function

    The authors investigated the ability of hydrocarbon stapled alpha-helical peptides to target FOXP3, the master transcription factor regulator of Treg cell development, maintenance, and suppressive function.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Full Article

    SET/PP2A Signaling Regulates Macrophage Positioning in Hypoxic Tumor Regions by Amplifying Chemotactic Responses

    Investigators reported that genetic deletion of SE translocation in myeloid cells inhibited the entry of tumor-associated macrophages into the hypoxic tumor region and abated their proangiogenic and immunosuppressive functions, ultimately inhibiting tumor growth.
    [Experimental & Molecular Medicine]

    Full Article

    Generation of Murine Tumor-Reactive T Cells by Co-Culturing Murine Pancreatic Cancer Organoids and Peripheral Blood Lymphocytes

    A pancreatic cancer organoid culture from a genetically engineered pancreatic cancer murine model was established and co-cultured with autologous peripheral blood lymphocytes to induce a tumour-specific T cell response to pancreatic cancer.
    [Biochemistry and Biophysics Reports]

    Full Article
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    REVIEWS

    Clinical Implications of T Cell Exhaustion for Cancer Immunotherapy

    The ‘un-exhausting’ of T cells in the tumour microenvironment is commonly regarded as a key mechanism of action for immune-checkpoint inhibitors, and T cell exhaustion is considered a pathway of resistance for cellular immunotherapies.
    [Nature Reviews Clinical Oncology]

    Abstract

    Epigenetic Regulation of B Cells and Its Role in Autoimmune Pathogenesis

    Epigenetic mechanisms, including those involving histone modifications, DNA methylation, and noncoding RNAs, regulate B-cell responses, and their dysregulation can contribute to the pathogenesis of autoimmune diseases.
    [Cellular & Molecular Immunology]

    Full Article
    INDUSTRY AND POLICY NEWS

    N.J. Entrepreneurs Give U. Penn $50 Million for Autoimmune Research Center

    Stewart and Judy Colton gave the University of Pennsylvania Perelman School of Medicine $50 million to support research on autoimmune disorders.
    [The Chronicle of Philanthropy]

    Press Release
    FEATURED EVENT

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    JOB OPPORTUNITIES

    PhD Student Positions – Tumor Ecosystem

    Luxembourg Institute of Health – Luxembourg, Luxembourg

    Associate Director – Histocompatibility Laboratory

    University of Michigan – Ann Arbor, Michigan, United States

    Assistant Professor – Cancer Organoids and Immuno-Oncology

    Aarhus University – Aarhus C, Denmark


    Research Associate – Autoimmune Genomics

    Michigan State University – East Lansing, Michigan, United Statesd

    Research Scientist – CRISPR Tools in Gene & Cell Therapies

    Alia Therapeutics – Trento, Italy

    > See All Jobs

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