 | | Vol. 10.39 – 12 October, 2022 |
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| Researchers present a systematic contactome map of SARS-CoV-2 with the human host encompassing more than 200 binary virus–host and intraviral protein–protein interactions.
[Nature Biotechnology] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators did a national population-based cohort study of women who had SARS-CoV-2 infection in pregnancy between May 17, 2021, and Jan 31, 2022. The primary maternal outcome was admission to critical care within 21 days of infection or death within 28 days of date of infection
[Lancet Respiratory Medicine] |
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| Scientists found a receptor binding domain–specific mAb 002-S21F2 that had rare gene usage and potently neutralized live viral isolates of SARS-CoV-2 variants including Alpha, Beta, Gamma, Delta, and Omicron sublineages with IC50 ranging from 0.02 to 0.13 μg/ml.
[Science Advances] |
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| As the first study conducted to test the direct effects of serum from hospitalised COVID-19 patients on human hippocampal neurogenesis, researchers utilized a unique in vitro experimental assay with human hippocampal progenitor cells.
[Molecular Psychiatry] |
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| The authors interrogated whether nucleocapsid-specific antibodies could improve protection against SARSCoV-2. They first immunized mice with a nucleocapsid-based vaccine, and then transferred sera from these mice into naïve mice, followed by challenge with SARS-CoV-2.
[Journal of Clinical Investigation] |
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| Researchers designed a chimeric triple-RBD immunogen, 3Ro-NC, harboring one Delta RBD and two Omicron RBDs within a novel protein scaffold. 3Ro-NC elicited potent and broad RBD-specific neutralizing immunity against SARS-CoV-2 variants of concern.
[Cellular & Molecular Immunology] |
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| Following the third dose S-specific binding and neutralizing antibodies increased 50-fold compared with post-dose 2 levels, with increased responses also evident in the lower airways and against the SARS-CoV-2 B.1.1.7 (Alpha), B.1.351 (Beta), P.1 (Gamma) and B.1.617.2 (Delta) variants.
[Molecular Therapy-Methods & Clinical Development] |
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| MORE IMMUNOLOGY OF INFECTIOUS DISEASE |
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| T cell–specific deletion of Orai1 did not exacerbate pulmonary inflammation and viral burdens following IAV infection but protected mice from house dust mite–induced allergic airway inflammation.
[Science Advances] |
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| Scientists demonstrated that ex vivo, macrophage tissue reservoirs contained transcriptionally active HIV-1 and viral particles accumulated in virus-containing compartments, and harbored an inflammatory IL-1R+S100A8+MMP7+M4-phenotype prone to glycolysis.
[Nature Communications] |
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| Mechanistic exploration revealed that the capsule-less mutants remained able to induce species-specific immunoglobulin A and were highly IgA-coated. They could still trigger myeloid cells, and more effectively damaged epithelial cells in vitro.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Researchers demonstrated that the autophagy receptor, T6BP, influences both autophagy-dependent and -independent endogenous presentation of HIV- and HCMV-derived peptides.
[EMBO Reports] |
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| Scientists demonstrated that Viperin was increased in abundance in patients with lymphatic and pulmonary tuberculosis.
[Science Signaling] |
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| In ex vivo cells, mHLA-DR failed to augment in GG in comparison with AG or AA genotype upon exposure to IFN-γ. Promoter III transcript levels were similar in control monocytes regardless of genotype and exposure to IFN-γ.
[iScience] |
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| Researchers showed that double-positive cells in blood contained more HIV DNA compared with double-negative cells but still had a lower proportion of cells producing multiply spliced HIV RNA after stimulation as well as reduced upregulation of T cell activation and proliferation markers.
[Cell Reports Medicine] |
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| The increasing scientific evidence concerning the origins of SARS-CoV-2 is most consistent with a zoonotic origin and a spillover pathway from wildlife to people via wildlife farming and the wildlife trade.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| In the wake of the COVID-19 pandemic, plans are afoot to build more than 40 high-level biosafety laboratories around the world, including in India, the Philippines and Singapore.
[Nature News] |
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| About 120 countries have now authorized COVID-19 vaccines for use in children, reaching hundreds of millions of arms. The majority of vaccines have been approved for children aged five and older, but a dozen or so countries have also started to administer them to infants from six months old.
[Nature News] |
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| The Investigator Grant scheme is NHMRC’s largest funding scheme and a major investment in Australia’s health and medical research workforce. The scheme awards around $370 million in research funding each year.
[National Health and Medical Research Council] |
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| November 6 – 8, 2022
Seville, Spain |
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| | Cedars-Sinai – Los Angeles, California, United States |
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| | University of Michigan – Ann Arbor, Michigan, United States |
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| | University of Alberta – Edmonton, Alberta, Canada |
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| | University of Calgary – Calgary, Alberta, Canada |
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| | University of Wisconsin-Madison – Madison, Wisconsin, United States |
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