Intestinal Cell News Volume 8.32 | Sep 2 2022

    By
    Bob
    -
    0
    17








    2022-09-02 | ICN 8.32


    Intestinal Cell News by STEMCELL Technologies
    Vol. 8.32 – 2 September, 2022
    TOP STORY

    Hepatic Cytochrome P450 8B1 and Cholic Acid Potentiate Intestinal Epithelial Injury in Colitis by Suppressing Intestinal Stem Cell Renewal

    Researchers revealed a connection between the hepatic cytochrome P450 8B1-cholic acid axis and colitis via regulating intestinal epithelial regeneration.
    [Cell Stem Cell]

    AbstractGraphical Abstract
    Explore Antibodies for Epithelial Cell Markers
    PUBLICATIONSRanked by the impact factor of the journal

    Gut Microbial DL-Endopeptidase Alleviates Crohn’s Disease via the NOD2 Pathway

    Investigators demonstrated that the Firmicutes peptidoglycan remodeling enzyme, DL-endopeptidase, increased the NOD2 ligand level in the gut and impacted colitis outcomes.
    [Cell Host & Microbe]

    Full ArticleGraphical Abstract

    The Drug Efflux Pump MDR1 Promotes Intrinsic and Acquired Resistance to PROTACs in Cancer Cells

    Using proteomic analysis, researchers found intrinsic and acquired resistance mechanisms to proteolysis-targeting chimeras (PROTACs) in cancer cell lines mediated by greater abundance or production of the drug efflux pump MDR1.
    [Science Signaling]

    Full Article

    Modification of Diet to Reduce the Stemness and Tumorigenicity of Murine and Human Intestinal Cells

    The authors used immunohistochemistry, gene expression analysis, and organoid culture to evaluate the effect of black raspberries on intestinal homeostasis.
    [Molecular Nutrition & Food Research]

    Full Article

    Decreased NHE3 Expression in Colon Cancer Is Associated with DNA Damage, Increased Inflammation and Tumor Growth

    showed that Na+/H+ exchanger 3 (NHE3) mRNA expression was significantly reduced in colorectal cancer patients and that low NHE3 expression was associated with poorer survival.
    [Scientific Reports]

    Full Article

    Analyses of the Expression and Prognosis of ILDR1 in Human Gastric Cancer

    Investigators analyzed the expression of immunoglobulin-like domain containing receptor 1 (ILDR1) and its relationship with clinical outcomes in gastric cancer using publicly available databases.
    [Heliyon]

    Full Article

    Scientific resources to support your organoids research. Learn More!
    REVIEWS

    Cell Death Affecting the Progression of Gastric Cancer

    The authors summarize the effects of necrosis, apoptosis, necroptosis, pyroptosis, ferroptosis, and eight less common cell death modalities on gastric cancer cells and the tumor microenvironment.
    [Cell Death Discovery]

    Full Article
    INDUSTRY AND POLICY NEWS

    Lab Leaders Wrestle with Paucity of Postdocs

    A complex mix of politics, economics and shifting career priorities has made it hard for principal investigators to recruit new lab members.
    [Nature News]

    Press Release
    FEATURED EVENT

    Organoids as Models of Development and Disease, and Their Impact on Drug Discovery

    February 5 – 8, 2023
    Keystone, Colorado, United States

    > See All Events

    JOB OPPORTUNITIES

    Senior Researcher – Intestinal Microbiology

    Technical University of Denmark – Lyngby, Denmark

    Research Associate – Molecular Diagnostics and Experimental Therapeutics

    Beckman Research Institute of City of Hope – Duarte, California, United States

    Research Technologist – Tissue and Cell Biology

    STEMCELL Technologies, Inc. – Vancouver, British Columbia, Canada

    Associate Professor – Solid Cancer Tumor Development

    Michigan State University – East Lansing, Michigan, United States

    Postdoctoral Scholar – Host Microbial Interactions and Gastrointestinal COVID-19

    Washington University in St. Louis – St. Louis, Missouri, United States

    > See All Jobs

    Submit an article, publication, job or event
    Brought to you by
    stemcell-logo-for newsletter-2
    Intestinal Cell News Twitter