Mammary Cell News Volume 14.19 | May 19 2022

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    2022-05-19 | MCN 14.19


    Mammary Cell News by STEMCELL Technologies
    Vol. 14.19 – 19 May, 2022
    TOP STORY

    PRMT Inhibition Induces a Viral Mimicry Response in Triple-Negative Breast Cancer

    The authors identified MS023, an inhibitor of type I protein arginine methyltransferases (PRMTs), which has antitumor growth activity in TNBC.
    [Nature Chemical Biology]

    Full ArticleGraphical Abstract
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    N6-Methyladenosine Regulated FGFR4 Attenuates Ferroptotic Cell Death in Recalcitrant HER2-Positive Breast Cancer

    Using genome-wide CRISPR/Cas9 screening in vitro and in vivo, scientists identified FGFR4 as an essential gene following anti-HER2 treatment.
    [Nature Communications]

    Full Article

    Transcriptional Repression by FoxM1 Suppresses Tumor Differentiation and Promotes Metastasis of Breast Cancer

    Using CRISPR-Cas9 engineering, investigators generated a mouse model that expressed Forkhead box M1 (FoxM1) harboring point mutations that blocked binding to Rb while retaining its ability to bind CREB-binding protein.
    [Cancer Research]

    Abstract

    DPYSL2 Interacts with JAK1 to Mediate Breast Cancer Cell Migration

    Dihydropyrimidinase-like 2 (DPYSL2) knockout in mesenchymal-like breast cancer cells profoundly inhibited cell migration, invasion, stemness features, tumor growth rate, and metastasis.
    [Journal of Cell Biology]

    Abstract

    NSrp70 Suppresses Metastasis in Triple-Negative Breast Cancer by Modulating Numb/TβR1/EMT Axis

    Multiple in vitro and in vivo functional analyses were used to study the effects of nuclear speckle-related protein 70 (NSrp70) on breast cancer metastasis.
    [Oncogene]

    Abstract

    RHAMM Expression Tunes the Response of Breast Cancer Cell Lines to Hyaluronan

    Researchers used a unidirectional hyaluronan (HA) gradient to investigate in a high-throughput fashion the bi-directional communication between HA and breast cancer cell lines with different surface expression of CD44 and receptor for hyaluronan-mediated motility (RHAMM).
    [Acta Biomaterialia]

    AbstractGraphical Abstract

    RNA Binding Protein POP7 Regulates ILF3 mRNA Stability and Expression to Promote Breast Cancer Progression

    The authors showed that expression of processing of precursor 7 (POP7) was frequently increased in breast cancer cells and in primary breast tumors.
    [Cancer Science]

    Abstract

    Antiproliferative and Apoptotic Potential of Methotrexate Lipid Nanoparticle in Murine Breast Cancer Model

    Scientists evaluated the efficacy of novel methotrexate-loaded nanoparticles in vitro and in vivo in the treatment of breast cancer.
    [Nanomedicine]

    Abstract

    CircEIF3H-IGF2BP2-HuR Scaffold Complex Promotes TNBC Progression via Stabilizing HSPD1/RBM8A/G3BP1 mRNA

    Investigators performed high-throughput RNA-seq in paired breast cancer tissues and adjacent normal tissues and discovered a novel circRNA, circEIF3H, which was upregulated in breast cancer tissues.
    [Cell Death Discovery]

    Full Article

    TRPC5OS Induces Tumorigenesis by Increasing ENO1-Mediated Glucose Uptake in Breast Cancer

    Researchers elucidated the function of transient receptor potential channel 5 opposite strand (TRPC5OS) in aberrant metabolism mediated tumorigenesis.
    [Translational Oncology]

    Full Article

    Low Expression of PCK2 in Breast Tumors Contributes to Better Prognosis via Inducing Senescence of Cancer Cells

    Verification in cultured breast cancer cells indicated that phosphoenolpyruvate carboxykinase 2 (PCK2) was significantly inhibited after therapy treatment.
    [IUBMB Life]

    Abstract
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    REVIEWS

    Wnt Signaling in the Breast: From Development to Disease

    Investigators dissect the fundamental role of Wnt signaling in mammary gland development and adult homeostasis and explore how defects are interlinked with cancer, with a focus on the breast.
    [Frontiers in Cell and Developmental Biology]

    Full Article

    The Potential Role of Nicotine in Breast Cancer Initiation, Development, Angiogenesis, Invasion, Metastasis, and Resistance to Therapy

    The authors review the mechanistic function of nicotine in the initiation, development, angiogenesis, invasion, metastasis, and apoptosis of breast cancer with the main focus on nicotine acetylcholine receptors.
    [Breast Cancer]

    Abstract
    INDUSTRY AND POLICY NEWS

    Zenith Epigenetics Announces Initiation of a Phase IIb Triple Negative Breast Cancer (TNBC) Clinical Trial

    Zenith Epigenetics Ltd. announced the initiation of a Phase IIb TNBC clinical trial combining ZEN-3694 + Pfizer Inc.’s Talzenna.
    [Zenith Epigenetics Ltd.]

    Press Release
    FEATURED EVENT

    3D Cell Culture Symposium

    September 15, 2022
    Online

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    JOB OPPORTUNITIES

    Principal Investigator – Interdisciplinary Research in Biology

    CNRS – Paris, France

    Postdoctoral Fellow – Breast Cancer and Leukemia

    Duke University – Durham, North Carolina, United States

    Senior Scientific Associate – Systems Cancer Pathology

    University of Cambridge – Cambridge, England, United Kingdom

    PhD Position – Breast Epithelium Organization and Cell Invasion

    Jülich Research Centre – Jülich, Germany

    Chief – Breast Medical Oncology

    Temple University – Philadelphia, Pennsylvania, United States

    > See All Jobs

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